INT130477

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Context Info
Confidence 0.29
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.59
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Fyn) mitochondrion (Fyn) plasma membrane (Fyn)
kinase activity (Fyn)
Anatomy Link Frequency
myeloid cells 1
platelet 1
Fyn (Mus musculus)
Pain Link Frequency Relevance Heat
antagonist 2 99.28 Very High Very High Very High
Neuropathic pain 8 97.58 Very High Very High Very High
Spinal cord 4 93.40 High High
Dorsal horn 2 92.64 High High
Neuronal nitric oxide synthase 1 92.24 High High
nMDA receptor 4 90.44 High High
Pain 4 74.76 Quite High
agonist 1 53.92 Quite High
fibrosis 3 18.28 Low Low
Central nervous system 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuropathic Pain 9 97.58 Very High Very High Very High
Nervous System Injury 1 94.44 High High
Erythrocytosis 35 92.28 High High
Reticulocytosis 5 82.64 Quite High
Aneuploidy 1 78.92 Quite High
Stress 1 77.56 Quite High
Hematological Disease 4 75.56 Quite High
Pain 1 74.76 Quite High
Myelodysplastic Syndromes 62 62.80 Quite High
Disease 11 55.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Neuropathic pain and NR2B phosphorylation at Tyr1472 were attenuated by the NR2B-selective antagonist CP-101,606 and disappeared in mice lacking Fyn kinase, a Src-family tyrosine kinase.
Negative_regulation (lacking) of Fyn associated with antagonist and neuropathic pain
1) Confidence 0.29 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.75 Pain Relevance 1.14
There is a possibility that one or more of the other six vertebrate Src family kinases might compensate for lack of these three, particularly Fyn, Yes, and c-Src, which are expressed in myeloid cells.
Negative_regulation (lack) of Fyn in myeloid cells
2) Confidence 0.26 Published 2006 Journal PLoS ONE Section Body Doc Link PMC1762384 Disease Relevance 0.77 Pain Relevance 0
Dasatinib was initially developed as an inhibitor of the Src family of kinases such as Fyn, Yes, Src, and Lyk, but it also inhibits BCR-ABL, EphA2, platelet-derived growth factor receptor, and c-Kit.
Negative_regulation (inhibitor) of Fyn in platelet
3) Confidence 0.19 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2697539 Disease Relevance 0.08 Pain Relevance 0

General Comments

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