INT130478

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Context Info
Confidence 0.75
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 2.49
Pain Relevance 5.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
neurons 2
lamina 2
spinal cord 1
brain 1
forebrain 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 409 100.00 Very High Very High Very High
antagonist 97 100.00 Very High Very High Very High
Dorsal horn 78 99.84 Very High Very High Very High
Spinal cord 66 98.56 Very High Very High Very High
Central grey 79 97.60 Very High Very High Very High
Neuropathic pain 17 97.56 Very High Very High Very High
Potency 2 97.04 Very High Very High Very High
Dorsal horn neuron 36 96.52 Very High Very High Very High
Hippocampus 43 95.28 Very High Very High Very High
long-term potentiation 115 93.52 High High
Disease Link Frequency Relevance Heat
Targeted Disruption 140 99.28 Very High Very High Very High
Urological Neuroanatomy 80 97.60 Very High Very High Very High
Neuropathic Pain 52 97.56 Very High Very High Very High
Anxiety Disorder 32 91.84 High High
Pain 133 90.24 High High
Congenital Anomalies 14 88.24 High High
Pressure And Volume Under Development 3 86.32 High High
Nervous System Injury 15 82.20 Quite High
Inflammatory Pain 13 79.88 Quite High
Shock 12 76.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Electron microscopy showed that the phosphorylated NR2B was localized at the postsynaptic density in the spinal cord of mice with neuropathic pain.
Localization (localized) of NR2B in spinal cord associated with neuropathic pain and spinal cord
1) Confidence 0.75 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.71 Pain Relevance 1.24
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
Localization (localization) of NR2B in forebrain associated with dorsal horn
2) Confidence 0.64 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.29 Pain Relevance 0.45
These results indicate that both NR2A and NR2B-containing NMDA receptors were impaired in transgenic CA1 hippocampal neurons.


Localization (receptors) of NR2B-containing in neurons associated with targeted disruption and nmda receptor
3) Confidence 0.53 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.16 Pain Relevance 0.56
These results support our interpretation that both types of NR2 subunits, NR2A/B and NR2C/D are present on inhibitory interneurons of lamina II.
Localization (types) of NR2A/B in lamina
4) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.24
During postnatal development, NR2B is replaced by other NR2 subunits [10].
Localization (replaced) of NR2B
5) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.11
While the dominant synaptic receptors are NR2A/B type receptors, our bath application data indicate that NR2C/D receptors as well as NR2A/B receptors are expressed by inhibitory neurons and these may be extrasynaptic.
Localization (receptors) of NR2A/B in neurons
6) Confidence 0.53 Published 2010 Journal Mol Pain Section Body Doc Link PMC2879240 Disease Relevance 0 Pain Relevance 0.15
g) from the PAG of mice were separated and electrotransferred onto PDVF membranes (Invitrogen), which were probed with anti-NR2A, anti-NR2B, anti-GluR1 (Chemicon), and with ?
Localization (anti) of NR2B associated with central grey
7) Confidence 0.53 Published 2009 Journal Mol Pain Section Body Doc Link PMC2803476 Disease Relevance 0.52 Pain Relevance 0.37
The absence of Neto1 had no effect on the overall abundance of NR1, NR2A, NR2B, PSD-95, GluR2, VAMP2, or GABAAR1 proteins (Figure 6L) in whole brain extracts, or of NR1, NR2A, NR2B, or PSD-95 in crude synaptosomes (Figure 6M).
Localization (abundance) of NR2B in brain
8) Confidence 0.51 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0.17 Pain Relevance 0.05
While published evidence suggests expression of both NR2A/B and NR2C/D subunit types in the dorsal horn generally, our data, collected on subpopulations of lamina I neurons, show cell specific differences.
Localization (types) of NR2A/B in lamina associated with dorsal horn
9) Confidence 0.50 Published 2008 Journal Mol Pain Section Body Doc Link PMC2572590 Disease Relevance 0 Pain Relevance 0.36
20HA co-immunoprecipitated with both NR2A (Figure 5A, lanes 1 and 2, and Figure 5C, lane 4) and NR2B (Figure 5B, lanes 1 and 2, and Figure 5C, lane 5) expressed in the absence of NR1 and PSD-95.
Localization (immunoprecipitated) of NR2B
10) Confidence 0.45 Published 2009 Journal PLoS Biology Section Body Doc Link PMC2652390 Disease Relevance 0 Pain Relevance 0
Bath application of a NR2A antagonist NVP-AAM077 and NR2B antagonist ifenprodil/Ro compounds produce almost completely blockade of NMDA receptor mediated EPSCs.
Localization (application) of NR2B associated with nmda receptor and antagonist
11) Confidence 0.31 Published 2007 Journal Mol Pain Section Body Doc Link PMC1904186 Disease Relevance 0.34 Pain Relevance 1.20
Our results suggest that Dimebon does not display selectivity for NR2B subtype of NMDAR, as both WT and YAC128 MSN currents were inhibited with similar potency (Fig 3B).
Localization (subtype) of NR2B associated with potency
12) Confidence 0.28 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2577671 Disease Relevance 0 Pain Relevance 0.09
The data suggest that PSD-93 is required for synaptic expression and localization of NR2A and NR2B in dorsal horn and forebrain cortex.
Localization (localization) of NR2B in dorsal horn associated with dorsal horn
13) Confidence 0.22 Published 2008 Journal Mol Pain Section Body Doc Link PMC2576175 Disease Relevance 0.29 Pain Relevance 0.45

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