INT130479

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Context Info
Confidence 0.77
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 28
Total Number 40
Disease Relevance 34.82
Pain Relevance 34.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Grin2b) plasma membrane (Grin2b) embryo development (Grin2b)
Anatomy Link Frequency
spinal cord 8
dorsal horn 7
spinal 2
synapses 1
body 1
Grin2b (Mus musculus)
Pain Link Frequency Relevance Heat
nMDA receptor 263 100.00 Very High Very High Very High
Neuropathic pain 391 99.90 Very High Very High Very High
Spinal cord 527 99.84 Very High Very High Very High
Dorsal horn 289 99.84 Very High Very High Very High
Morphine 63 99.84 Very High Very High Very High
withdrawal 77 99.80 Very High Very High Very High
antagonist 108 99.74 Very High Very High Very High
Pain 1433 99.60 Very High Very High Very High
Hippocampus 27 99.46 Very High Very High Very High
Spontaneous pain 43 99.32 Very High Very High Very High
Disease Link Frequency Relevance Heat
Neuropathic Pain 609 99.90 Very High Very High Very High
Cancer 1140 99.84 Very High Very High Very High
Targeted Disruption 897 99.44 Very High Very High Very High
Pain 1501 99.40 Very High Very High Very High
Nervous System Injury 61 99.08 Very High Very High Very High
INFLAMMATION 311 98.84 Very High Very High Very High
Pancreatic Cancer 255 98.84 Very High Very High Very High
Hyperalgesia 175 98.32 Very High Very High Very High
Inflammatory Pain 117 97.72 Very High Very High Very High
Injury 65 96.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Indomethacin, an inhibitor of prostaglandin (PG) synthesis, and PGE receptor subtype EP1-selective antagonist reduced the NR2B phosphorylation in these mice.
Phosphorylation (phosphorylation) of NR2B associated with antagonist
1) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.65 Pain Relevance 1.19
Electron microscopy showed that the phosphorylated NR2B was localized at the postsynaptic density in the spinal cord of mice with neuropathic pain.
Phosphorylation (phosphorylated) of NR2B in spinal cord associated with neuropathic pain and spinal cord
2) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.71 Pain Relevance 1.19
Concomitant with the NR2B phosphorylation, an increase in neuronal nitric oxide synthase activity was visualized in the superficial dorsal horn of neuropathic pain mice by NADPH diaphorase histochemistry.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with neuropathic pain, dorsal horn and neuronal nitric oxide synthase
3) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.75 Pain Relevance 1.17
Fyn kinase-mediated phosphorylation of NMDA receptor NR2B subunit at Tyr1472 is essential for maintenance of neuropathic pain.
Phosphorylation (phosphorylation) of NR2B associated with pain, nmda receptor and neuropathic pain
4) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Title Doc Link 16190898 Disease Relevance 0.70 Pain Relevance 1.30
Neuropathic pain and NR2B phosphorylation at Tyr1472 were attenuated by the NR2B-selective antagonist CP-101,606 and disappeared in mice lacking Fyn kinase, a Src-family tyrosine kinase.
Phosphorylation (phosphorylation) of NR2B associated with antagonist and neuropathic pain
5) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.76 Pain Relevance 1.11
The present study demonstrates that Tyr1472 phosphorylation of NR2B subunits by Fyn kinase may have dual roles in the retention of NMDA receptors in the postsynaptic density and in activation of nitric oxide synthase, and suggests that PGE2 is involved in the maintenance of neuropathic pain via the EP1 subtype.
Phosphorylation (phosphorylation) of NR2B associated with nmda receptor and neuropathic pain
6) Confidence 0.77 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.63 Pain Relevance 1.05
production in cancer-inoculated regions, which in turn inhibits ephrin B1 gene expression, and tyrosine phosphorylation of NR2B.
Phosphorylation (phosphorylation) of NR2B associated with cancer
7) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.70 Pain Relevance 1.12
production from cancer-inoculated regions induces the gene expression of ephrin B1 in DRGs, which then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord, finally leading to pain.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
8) Confidence 0.72 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.44 Pain Relevance 0.91
Wild-type, NR2A-deficient, and NR2D-deficient mice developed neuropathic pain; in addition, phosphorylation of NR2B subunits of NMDA receptors at Tyr1472 was observed in the superficial dorsal horn of the spinal cord 1 week after nerve injury.
Phosphorylation (phosphorylation) of NR2B in dorsal horn associated with nervous system injury, nmda receptor, dorsal horn, neuropathic pain and spinal cord
9) Confidence 0.67 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16190898 Disease Relevance 0.69 Pain Relevance 0.98
It is postulated that CaMKII phosphorylation of GluR1 and NR2A/B may play a role in increasing the presence of these receptors within retinal synapses.
Phosphorylation (phosphorylation) of NR2A/B in synapses
10) Confidence 0.65 Published 2001 Journal BMC Neurosci Section Body Doc Link PMC32198 Disease Relevance 0 Pain Relevance 0.05
First, it has been reported the regional difference of NMDARs in the ACC and hippocampus, such as NR2A/NR2B ratio, phosphorylated NR2A and NR2B [18] as well as regulations under chronic pain conditions [6].
Phosphorylation (phosphorylated) of NR2B in hippocampus associated with lasting pain, hippocampus and anterior cingulate cortex
11) Confidence 0.65 Published 2007 Journal Mol Pain Section Body Doc Link PMC1871573 Disease Relevance 0.10 Pain Relevance 0.32
We found no change in the phosphorylation of NMDA receptor subunits NR1, NR2A or NR2B in TgDREAM mice (Figure 5B).
Phosphorylation (phosphorylation) of NR2B associated with nmda receptor
12) Confidence 0.58 Published 2010 Journal Mol Brain Section Body Doc Link PMC2822766 Disease Relevance 0.14 Pain Relevance 0.58
We also found that the tyrosine phosphorylation of NR2B in the spinal cord was enhanced in the cancer-induced pain model in mice.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
13) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 2.17 Pain Relevance 1.44
Z-360 treatment inhibited both ephrin B1 gene expression and the phosphorylation of NR2B.
Phosphorylation (phosphorylation) of NR2B
14) Confidence 0.55 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.15 Pain Relevance 0.91
As it has been reported that ephrin B2 induces phosphorylation of Tyr-1472 residues [14], we next investigated whether Tyr-1472 phosphorylation of NR2B was enhanced in the spinal cord of the mouse model of cancer-induced pain.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
15) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.05 Pain Relevance 0.66
Tyrosine phosphorylation of NR2B
Phosphorylation (phosphorylation) of NR2B
16) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 0.28 Pain Relevance 0.18
Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 ?
Phosphorylation (phosphorylation) of NR2B associated with pancreatic cancer
17) Confidence 0.55 Published 2010 Journal Mol Pain Section Title Doc Link PMC2987997 Disease Relevance 0.95 Pain Relevance 0.76
production in cancer-inoculated regions induces ephrin B1 gene expression in DRGs and then ephrin B1 enhances the tyrosine phosphorylation of NR2B via Eph B receptor in the spinal cord.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with cancer and spinal cord
18) Confidence 0.55 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.32 Pain Relevance 1.09
In a mouse model of cancer-induced pain, ephrin B1 gene expression in dorsal root ganglia (DRGs) and the phosphorylation of NR2B in the spinal cord were induced.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with pain, cancer and spinal cord
19) Confidence 0.55 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC2987997 Disease Relevance 1.15 Pain Relevance 0.94
from a cancer-inoculated region, induction of ephrin B1 gene expression in DRGs, and subsequent enhancement of tyrosine phosphorylation of NR2B in the spinal cord.
Phosphorylation (phosphorylation) of NR2B in spinal cord associated with cancer and spinal cord
20) Confidence 0.55 Published 2010 Journal Mol Pain Section Body Doc Link PMC2987997 Disease Relevance 1.54 Pain Relevance 1.30

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