INT130496

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Context Info
Confidence 0.10
First Reported 2006
Last Reported 2006
Negated 0
Speculated 0
Reported most in Title
Documents 2
Total Number 2
Disease Relevance 0.63
Pain Relevance 0.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Kcnj8)
Anatomy Link Frequency
smooth muscle cells 1
Kcnj8 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Antinociceptive 2 99.16 Very High Very High Very High
calcitonin gene related peptide 5 99.00 Very High Very High Very High
Analgesic 1 98.10 Very High Very High Very High
Cannabinoid 6 97.14 Very High Very High Very High
Pain 2 95.36 Very High Very High Very High
spastic colon 1 84.08 Quite High
antagonist 1 75.40 Quite High
Endocannabinoid 1 69.16 Quite High
Spinal cord 1 63.28 Quite High
antinociception 1 52.52 Quite High
Disease Link Frequency Relevance Heat
Pain 1 95.36 Very High Very High Very High
Nociception 5 87.24 High High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

1 86.64 High High
Functional Bowel Disorder 1 84.08 Quite High
Colitis 1 65.92 Quite High
INFLAMMATION 1 41.16 Quite Low
Enteropathy 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings show that cannabinoids stimulate TRPV1 receptors, presumably causing the release of calcitonin gene related peptide, which hyperpolarizes the smooth muscle cells by activation of KATP channels.
Positive_regulation (activation) of KATP in smooth muscle cells associated with calcitonin gene related peptide and cannabinoid
1) Confidence 0.10 Published 2006 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 16495770 Disease Relevance 0 Pain Relevance 0.37
Evidence that hydrogen sulfide exerts antinociceptive effects in the gastrointestinal tract by activating KATP channels.
Positive_regulation (activating) of KATP associated with analgesic and antinociceptive
2) Confidence 0.05 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 16192316 Disease Relevance 0.54 Pain Relevance 0.41

General Comments

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