INT130497

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.77
First Reported 2006
Last Reported 2009
Negated 1
Speculated 2
Reported most in Body
Documents 5
Total Number 24
Disease Relevance 16.93
Pain Relevance 9.34

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Cbs) lyase activity (Cbs) nucleolus (Cbs)
nucleus (Cbs) enzyme binding (Cbs) cytoplasm (Cbs)
Anatomy Link Frequency
colon 7
neurons 7
sensory neurons 1
visceral 1
spinal cord 1
Cbs (Rattus norvegicus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 620 99.84 Very High Very High Very High
Spinal cord 2 99.28 Very High Very High Very High
nud 440 98.94 Very High Very High Very High
Catecholamine 3 96.84 Very High Very High Very High
Inflammation 204 96.20 Very High Very High Very High
spastic colon 202 96.00 Very High Very High Very High
tetrodotoxin 4 95.76 Very High Very High Very High
Action potential 200 94.60 High High
Neurotransmitter 21 93.48 High High
potassium channel 1 89.36 High High
Disease Link Frequency Relevance Heat
Ganglion Cysts 620 99.84 Very High Very High Very High
Colitis 2 99.36 Very High Very High Very High
Dyspepsia 440 98.94 Very High Very High Very High
Hypoxia 8 98.52 Very High Very High Very High
Nociception 130 97.20 Very High Very High Very High
INFLAMMATION 204 96.20 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

162 96.00 Very High Very High Very High
Functional Bowel Disorder 62 95.08 Very High Very High Very High
Syndrome 40 92.64 High High
Pain 162 82.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that CBS and CSE are expressed in the colon and spinal cord.
Gene_expression (expressed) of CBS in spinal cord associated with spinal cord
1) Confidence 0.77 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16192316 Disease Relevance 0.66 Pain Relevance 0.37
CBS expression is upregulated in the DRGs and colon in a rat model of CVH
Gene_expression (expression) of CBS in colon associated with nud
2) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.02 Pain Relevance 0.47
We then determined the effect of neonatal colonic infusion of acetic acid (AA) on CBS expression in DRG and colon.
Gene_expression (expression) of CBS in colon associated with dorsal root ganglion
3) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.92 Pain Relevance 0.42
Our results show that CVH in this model is associated with an upregulation of CBS expression in both thoracolumbar (TL) and lumbarsacral (LS) DRG and that the use of a CBS inhibitor attenuates colonic hypersensitivity.
Gene_expression (expression) of CBS associated with dorsal root ganglion and nud
4) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.27 Pain Relevance 1.00
We have confirmed previous studies on the expression of CBS and CSE in the colon and further have shown that CBS, but not CSE, is expressed by colon-specific sensory neurons (Fig. 1), where it is localized to nociceptive neurons, indicating that CBS is a major enzyme responsible for the endogenous production of H2S in these cells.
Gene_expression (expression) of CBS in colon associated with nociception
5) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.71 Pain Relevance 0.32
We have also shown that CBS expression in both sensory neurons and the colon is dynamic and is upregulated in a model of chronic non-inflammatory visceral hypersensitivity.
Gene_expression (expression) of CBS in sensory neurons associated with inflammation and nud
6) Confidence 0.77 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.58 Pain Relevance 0.29
We next examined whether CBS was co-expressed in TRPV1- or P2X3R-positive colon specific DRG neurons since these are two major molecules involved in transduction of nociceptive information.
Gene_expression (expressed) of CBS in neurons associated with nociception and dorsal root ganglion
7) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 1.05 Pain Relevance 0.48
CBS was predominantly expressed in small and medium-size neurons, with large DRG neurons staining weakly or not at all (Fig. 1C).
Gene_expression (expressed) of CBS in neurons associated with dorsal root ganglion
8) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.40 Pain Relevance 0.20
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Gene_expression (producing) of CBS in neurons associated with dorsal root ganglion
9) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.12
To determine whether colon specific DRG neurons expressed the CBS, double labeling studies were performed.
Spec (whether) Gene_expression (expressed) of CBS in neurons associated with dorsal root ganglion
10) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.77 Pain Relevance 0.36
We have confirmed previous studies on the expression of CBS and CSE in the colon and further have shown that CBS, but not CSE, is expressed by colon-specific sensory neurons (Fig. 1), where it is localized to nociceptive neurons, indicating that CBS is a major enzyme responsible for the endogenous production of H2S in these cells.
Neg (not) Gene_expression (expressed) of CBS in neurons associated with nociception
11) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.71 Pain Relevance 0.33
The H2S-producing enzyme CBS is expressed by colonic specific DRG neurons
Gene_expression (expressed) of CBS in neurons associated with dorsal root ganglion
12) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.29 Pain Relevance 0.12
We examined CBS expression in primary sensory neurons by immunohistochemistry.
Spec (examined) Gene_expression (expression) of CBS in primary sensory neurons
13) Confidence 0.67 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.35 Pain Relevance 0.15
Immunoblot assays demonstrated the presence of Na(v)alpha-subunit (c. 220 kDa) in crude homogenates from rat CBs, being evident an up-regulation (60%) of this protein in the CBs obtained from chronically hypoxic rats (10% O2; 7 days).
Gene_expression (presence) of CBs associated with hypoxia
14) Confidence 0.61 Published 2007 Journal J. Neurochem. Section Abstract Doc Link 17564680 Disease Relevance 0.49 Pain Relevance 0.55
Eight weeks later, the expression of CBS in colon-related DRGs (T13-L2 and L6-S2, bilateral), as assessed by Western blotting of protein extracts, was significantly greater than that from control rats (Fig. 4A&4B, p < 0.05).
Gene_expression (expression) of CBS in colon
15) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.86 Pain Relevance 0.42
Our results suggest that upregulation of CBS expression in colonic DRG neurons and H2S signaling may play an important role in developing CVH, thus identifying a specific neurobiological target for the treatment of CVH in functional bowel syndromes.



Gene_expression (expression) of CBS in neurons associated with dorsal root ganglion, syndrome and nud
16) Confidence 0.59 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2731739 Disease Relevance 1.08 Pain Relevance 0.64
Western blotting analysis showed that CBS expression was significantly increased in colon DRGs 8 weeks after neonatal AA-treatment.
Gene_expression (expression) of CBS in colon
17) Confidence 0.59 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2731739 Disease Relevance 1.16 Pain Relevance 0.92
In addition, a significant increase of CBS expression was noted in proximal and medium colon (but not distal colon) from rats with neonatal AA injection (Fig. 4C&4D).
Gene_expression (expression) of CBS in proximal
18) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.68 Pain Relevance 0.35
-synthase (CBS) is expressed by a subpopulation of primary sensory neurons (Figs. 1, 2 &3) and is upregulated in a rat model of IBS-like chronic visceral hyperalgesia (Fig. 4).
Gene_expression (expressed) of CBS in visceral associated with spastic colon and nud
19) Confidence 0.59 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.66 Pain Relevance 0.70
CBS-immunoreactivity (Fig. 2B&3B) was present in all DiI labeled colon specific DRG neurons (Fig. 2D&3D).


Gene_expression (present) of CBS in colon associated with dorsal root ganglion
20) Confidence 0.58 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731739 Disease Relevance 0.95 Pain Relevance 0.44

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox