INT130502

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 17
Disease Relevance 5.75
Pain Relevance 8.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transmembrane transport (Trpa1)
Anatomy Link Frequency
visceral 1
nerve 1
DRG 1
nociceptors 1
Trpa1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 229 100.00 Very High Very High Very High
TRP channel 163 100.00 Very High Very High Very High
Eae 45 99.48 Very High Very High Very High
Analgesic 16 99.28 Very High Very High Very High
antagonist 35 99.16 Very High Very High Very High
dorsal root ganglion 29 98.68 Very High Very High Very High
Potency 24 98.68 Very High Very High Very High
qutenza 185 98.40 Very High Very High Very High
intrathecal 9 98.20 Very High Very High Very High
Sciatic nerve 1 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Injury 13 99.48 Very High Very High Very High
Hypersensitivity 81 98.84 Very High Very High Very High
Ganglion Cysts 125 98.68 Very High Very High Very High
Neuropathic Pain 73 97.92 Very High Very High Very High
INFLAMMATION 130 97.68 Very High Very High Very High
Helminth Infection 2 97.12 Very High Very High Very High
Hyperalgesia 14 96.76 Very High Very High Very High
Nervous System Injury 13 94.52 High High
Pain 77 91.88 High High
Nociception 48 90.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our findings point to the potential blockade of TRPA1 in primary afferents as a new therapeutic target for the reduction of visceral hypersensitivity.


Negative_regulation (blockade) of TRPA1 in visceral
1) Confidence 0.59 Published 2009 Journal Gut Section Body Doc Link 19515638 Disease Relevance 0.06 Pain Relevance 0
In contrast to the efficacy achieved in the SNL model with pharmacological blockade of TRPA1, both mice lacking the function of TRPA1 and their wildtype littermates developed significant mechanical hypersensitivity in the spared nerve injury (SNI) model.
Negative_regulation (blockade) of TRPA1 in nerve associated with nervous system injury and hypersensitivity
2) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 1.27 Pain Relevance 0.47
Very recently, Petrus et al., (2007) showed that pharmacological inhibition of TRPA1 using intraplantar injection of the selective antagonist, AP-18, significantly attenuated CFA-induced mechanical hypersensitivity in TRPA1+/+ but not TRPA1-/- mice [27].
Negative_regulation (inhibition) of TRPA1 associated with antagonist and hypersensitivity
3) Confidence 0.58 Published 2008 Journal Mol Pain Section Body Doc Link PMC2584039 Disease Relevance 0.65 Pain Relevance 0.53
Inhibition of TRPA1 under pathological conditions, either using intrathecal antisense oligonucleotides (Katsura et al., 2006) or a locally administered antagonist (Petrus et al., 2007) ameliorates neuropathic or inflammatory cold hypersensitivity.
Negative_regulation (Inhibition) of TRPA1 associated with inflammation, antagonist, hypersensitivity, neuropathic pain and intrathecal
4) Confidence 0.58 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.62 Pain Relevance 0.38
In contrast, pharmacological inhibition of TRPA1 affects both cold and mechanical behavioural changes in more acute (hours) inflammation (Petrus et al., 2007).
Negative_regulation (inhibition) of TRPA1 associated with inflammation
5) Confidence 0.57 Published 2008 Journal The European Journal of Neuroscience Section Body Doc Link PMC2658012 Disease Relevance 1.44 Pain Relevance 1.09
TRPV1 and TRPA1 RNA were significantly decreased in DRG from RTX-treated rats, indicating functional colocalization of TRPA1 and TRPV1 in sensory nociceptors.
Negative_regulation (decreased) of TRPA1 in nociceptors associated with nociceptor
6) Confidence 0.56 Published 2007 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 17517374 Disease Relevance 0.53 Pain Relevance 0.45
It has been proposed that TRPA1 is “actively suppressed” (Reid, 2005) under normal conditions, and that channel activity may be relieved of suppression under pathological conditions.
Negative_regulation (suppressed) of TRPA1
7) Confidence 0.43 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.24 Pain Relevance 0.30
We hypothesised that if TRPA1 is a cold sensor/transducer in vivo, then agonist sensitisation of TRPA1 would also sensitise TRPA1 to cold stimulation, in just such a manner as exists in vitro for TRPM8 (McKemy et al., 2002; Peier et al., 2002).
Negative_regulation (sensitisation) of TRPA1 associated with agonist
8) Confidence 0.42 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0 Pain Relevance 0.25
We also found that camphor inhibited several other related TRP channels, including ankyrin-repeat TRP 1 (TRPA1).
Negative_regulation (inhibited) of TRPA1 associated with trp channel
9) Confidence 0.41 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192383 Disease Relevance 0 Pain Relevance 0.87
It has recently been demonstrated that inhibition of TRPA1 function reduces mechanical hypersensitivity produced by inflammation [15,17].
Negative_regulation (inhibition) of TRPA1 associated with inflammation and hypersensitivity
10) Confidence 0.39 Published 2010 Journal Mol Pain Section Body Doc Link PMC2891679 Disease Relevance 0.66 Pain Relevance 0.64
Gene expression analysis for various thermo-sensitive transient receptor potential (TRP) channels indicated marked reductions in the mRNA levels of TRPV1 (70%), TRPM8 (46%) and TRPA1 (64%), but not of TRPV2, in the DRG of capsaicin-treated rats compared with those in the control rats.
Negative_regulation (reductions) of TRPA1 in DRG associated with dorsal root ganglion and qutenza
11) Confidence 0.38 Published 2008 Journal J. Biochem. Section Abstract Doc Link 18079164 Disease Relevance 0.29 Pain Relevance 0.69
The camphor-induced desensitization of TRPV1 and block of TRPA1 may underlie the analgesic effects of camphor.
Negative_regulation (desensitization) of TRPA1 associated with analgesic
12) Confidence 0.30 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192383 Disease Relevance 0 Pain Relevance 0.81
Citral inhibited the agonist-evoked activity of TRPV1–4, TRPM8, and TRPA1 (Fig. 2C, F); citral's order of potency for inhibition was TRPV4>TRPV1>TRPM8?
Negative_regulation (inhibited) of TRPA1 associated with agonist and potency
13) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.41
Citral is both an activator and inhibitor of TRPV1, TRPV3, TRPM8, and TRPA1, but these opposing actions cannot be attributed to the cis and trans enantiomers.
Negative_regulation (inhibitor) of TRPA1
14) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.38
Citral inhibition of TRPV1–4, TRPM8, and TRPA1
Negative_regulation (inhibition) of TRPA1
15) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.43
Reapplication of citral reduced TRPA1 current (tachyphylactic response; Fig.
Negative_regulation (reduced) of TRPA1
16) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2346451 Disease Relevance 0 Pain Relevance 0.10
The Ca(2+) responses of these compounds for TRPV1 and TRPA1 were significantly suppressed by co-applying each antagonist.
Negative_regulation (suppressed) of TRPA1 associated with antagonist
17) Confidence 0.17 Published 2010 Journal Biosci. Biotechnol. Biochem. Section Abstract Doc Link 20460725 Disease Relevance 0 Pain Relevance 0.26

General Comments

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