INT130506

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Context Info
Confidence 0.12
First Reported 2005
Last Reported 2009
Negated 2
Speculated 1
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.56
Pain Relevance 2.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Ptges) cytoplasm (Ptges)
Anatomy Link Frequency
lymph node 1
liver 1
fibroblasts 1
Ptges (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Morphine 9 99.76 Very High Very High Very High
tolerance 9 99.50 Very High Very High Very High
Pain 4 98.72 Very High Very High Very High
acular 4 98.60 Very High Very High Very High
Inflammation 39 98.36 Very High Very High Very High
aspirin 1 97.66 Very High Very High Very High
Calcitonin gene-related peptide 7 95.00 High High
COX-2 inhibitor 3 94.72 High High
allodynia 1 92.88 High High
Hyperalgesia 2 92.32 High High
Disease Link Frequency Relevance Heat
Fever 119 99.44 Very High Very High Very High
Pain 5 98.72 Very High Very High Very High
INFLAMMATION 53 98.36 Very High Very High Very High
Pleurisy 3 98.28 Very High Very High Very High
Nociception 7 94.32 High High
Neuropathic Pain 1 92.88 High High
Hyperalgesia 3 92.32 High High
Targeted Disruption 2 89.40 High High
Arthritis 3 74.60 Quite High
Apoptosis 1 33.56 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The roles of COX-1, COX-2, and the inducible microsomal PGES-1 have been studied in models of pain and inflammation.
Regulation (roles) of PGES-1 associated with pain and inflammation
1) Confidence 0.12 Published 2005 Journal J. Neurosci. Section Abstract Doc Link 16192391 Disease Relevance 0.70 Pain Relevance 0.47
Interestingly, the inhibition of the ERK pathway suppressed the development of tolerance and morphine-induced up-regulation of IL-1beta, TNF-alpha, and mPGES-1.
Regulation (regulation) of mPGES-1 associated with tolerance and morphine
2) Confidence 0.05 Published 2009 Journal FASEB J. Section Abstract Doc Link 19299480 Disease Relevance 0.06 Pain Relevance 1.77
Similar results were observed when investigating the effects of resveratrol on mPGES-1 protein levels as assessed by Western blotting (Fig. 4A).
Spec (investigating) Regulation (effects) of mPGES-1
3) Confidence 0.04 Published 2007 Journal J Neuroinflammation Section Body Doc Link PMC2100038 Disease Relevance 0 Pain Relevance 0
In human synovial fibroblasts, transcriptional regulation of the mPGES-1 gene by IL-1?
Regulation (regulation) of mPGES in fibroblasts
4) Confidence 0.03 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1297580 Disease Relevance 0.07 Pain Relevance 0.04
Although aspirin, indomethacin and a COX-1 inhibitor, ketorolac, significantly decreased the volume of pleural exudate, they did not affect the levels of COX-2 and mPGES-1 in the lymph node 24 h after induction of pleurisy.
Neg (not) Regulation (affect) of mPGES-1 in lymph node associated with aspirin, pleurisy and acular
5) Confidence 0.01 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17258197 Disease Relevance 0.40 Pain Relevance 0.34
In the liver, the immunohistochemical analysis (which is more sensitive) revealed a surge in the number of COX-2–positive cells at the onset of fever (Figure 4), whereas the Western blot analysis (less sensitive) found a tendency for an increase in the overall content of COX-2 and no changes in the content of either p-cPLA2 or mPGES-1 (Figure 3).
Neg (no) Regulation (changes) of mPGES-1 in liver associated with fever
6) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.57 Pain Relevance 0.09
Whereas the physiological importance of cPLA2 and mPGES-1 in the first febrile phase remains to be confirmed in studies with pharmacological or genetic blockade of these enzymes, the indispensable role of COX-2 (and the uninvolvement of COX-1) in the first phase of LPS fever have been demonstrated in our recent study in knockout mice [47].
Regulation (importance) of mPGES-1 associated with targeted disruption and fever
7) Confidence 0.01 Published 2006 Journal PLoS Biology Section Body Doc Link PMC1551923 Disease Relevance 0.75 Pain Relevance 0.07

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