INT13051

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Context Info
Confidence 0.12
First Reported 1991
Last Reported 2010
Negated 2
Speculated 3
Reported most in Abstract
Documents 12
Total Number 15
Disease Relevance 2.09
Pain Relevance 5.06

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Kcnma1) plasma membrane (Kcnma1)
Anatomy Link Frequency
neuronal 1
neurons 1
C127 1
microglia 1
GH3 1
Kcnma1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 103 100.00 Very High Very High Very High
TRP channel 24 100.00 Very High Very High Very High
sodium channel 4 100.00 Very High Very High Very High
vanilloid receptor subtype 1 2 100.00 Very High Very High Very High
qutenza 75 99.98 Very High Very High Very High
opiate 1 99.48 Very High Very High Very High
cINOD 2 99.00 Very High Very High Very High
Cancer pain 2 98.00 Very High Very High Very High
Inflammation 31 96.60 Very High Very High Very High
dorsal root ganglion 7 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Disease 5 99.64 Very High Very High Very High
Nociception 11 98.72 Very High Very High Very High
Cancer Pain 2 98.00 Very High Very High Very High
INFLAMMATION 31 96.60 Very High Very High Very High
Ganglion Cysts 10 95.92 Very High Very High Very High
Pain 39 92.60 High High
Neuropathic Pain 7 92.12 High High
Inflammatory Pain 6 91.48 High High
Stroke 21 81.08 Quite High
Neurogenic Inflammation 1 80.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluctuations of the channel activity in cell-attached patches and the fast disappearance after excision suggest that this channel is under metabolic control.
Regulation (under) of channel
1) Confidence 0.12 Published 1991 Journal Pflugers Arch. Section Abstract Doc Link 1660598 Disease Relevance 0 Pain Relevance 0.07
The effects of scorpion venom heat resistant protein (SVHRP) on sodium channel were studied in freshly isolated hippocampal neurons in rat using the whole-cell patch-clamp technique.
Regulation (effects) of channel in neurons associated with sodium channel
2) Confidence 0.11 Published 2007 Journal Sheng Li Xue Bao Section Abstract Doc Link 17579781 Disease Relevance 0 Pain Relevance 0.18
Moreover, its roles in microglia must be considered when targeting this channel for CNS diseases, disorders and reducing neuron hyper-excitability.



Regulation (targeting) of channel in microglia associated with disease
3) Confidence 0.04 Published 2010 Journal J Neuroinflammation Section Abstract Doc Link PMC2819255 Disease Relevance 0.48 Pain Relevance 0.05
Moreover, the neuronal K(+) channel and heterologously expressed TASK-1 were similarly modulated by extracellular pH.
Regulation (modulated) of channel in neuronal
4) Confidence 0.03 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10964940 Disease Relevance 0 Pain Relevance 0.24
To test whether this Ca2+ influx affects the levels of Na+ channel mRNAs, we first examined which Na+ channel subunits are expressed in GH3 cells.
Spec (whether) Regulation (affects) of channel in GH3
5) Confidence 0.03 Published 2003 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12941467 Disease Relevance 0 Pain Relevance 0.59
Capsaicin acts on the vanilloid receptor subtype 1, a noxious heat-gated cation channel located on a major subgroup of nociceptive primary afferent neurons.
Regulation (acts) of channel in afferent neurons associated with nociception, vanilloid receptor subtype 1 and qutenza
6) Confidence 0.02 Published 2002 Journal Neuroscience Section Abstract Doc Link 12182898 Disease Relevance 0.46 Pain Relevance 0.55
Caution is therefore warranted when employing this compound to examine the role of PLC and PIP(2) in the regulation of GIRK channel activity.
Spec (examine) Regulation (regulation) of channel
7) Confidence 0.02 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18358607 Disease Relevance 0 Pain Relevance 0.03
4 have also been cloned and shown to regulate Nav channel ?
Regulation (regulate) of channel
8) Confidence 0.01 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752992 Disease Relevance 0 Pain Relevance 0.98
Functional changes in the vanilloid receptor subtype 1 channel during and after acute desensitization.
Regulation (changes) of channel associated with vanilloid receptor subtype 1 and qutenza
9) Confidence 0.00 Published 2007 Journal Neuroscience Section Title Doc Link 17869438 Disease Relevance 0.18 Pain Relevance 0.43
TRP channel block of cold and TRPA1 agonist responses in cutaneous primary afferents
Regulation (responses) of channel associated with trp channel and agonist
10) Confidence 0.00 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0.18 Pain Relevance 0.52
Experimentally, this is evident by the modulation of channel open probability by agonist and temperature (Babes et al., 2002; McKemy et al., 2002; Peier et al., 2002).
Spec (evident) Regulation (modulation) of channel associated with agonist
11) Confidence 0.00 Published 2010 Journal Neuroscience Section Body Doc Link PMC2860241 Disease Relevance 0 Pain Relevance 0.29
Also, as shown in Figure 3, both atractyloside and bongkrekic acid, potent AAC blockers, failed to affect the activity of the maxianion channel in C127 cells either from intracellular or from extracellular side.
Regulation (affect) of channel in C127
12) Confidence 0.00 Published 2005 Journal Purinergic Signal Section Body Doc Link PMC2096548 Disease Relevance 0.23 Pain Relevance 0.10
However, pharmacological studies are controversial and argue against the actual involvement of the VSOR channel in significant release of ATP.
Regulation (involvement) of channel
13) Confidence 0.00 Published 2005 Journal Purinergic Signal Section Abstract Doc Link PMC2096548 Disease Relevance 0.11 Pain Relevance 0.05
Our data suggest that application of neuroleptics in severe cancer pain may enhance and complement efficacy of conventional painkillers by direct inhibition of TRPV1 Ca2+-channel, an alternative target not used by opiates and NSAIDs.
Neg (not) Regulation (target) of channel associated with cancer pain, cinod and opiate
14) Confidence 0.00 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1890308 Disease Relevance 0.34 Pain Relevance 0.70
However, this protein had no significant effect on VR1 channel activity in response to CAP.
Neg (no) Regulation (effect) of channel associated with qutenza
15) Confidence 0.00 Published 2005 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 15883036 Disease Relevance 0.10 Pain Relevance 0.29

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