INT130552

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Context Info
Confidence 0.31
First Reported 2005
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.37
Pain Relevance 1.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transducer activity (Oprm1)
Anatomy Link Frequency
muscle 2
Oprm1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 7 100.00 Very High Very High Very High
Morphine 6 99.56 Very High Very High Very High
antagonist 1 87.28 High High
medulla 1 78.92 Quite High
mu opioid receptor 4 77.04 Quite High
Rostral ventrolateral medulla 3 76.96 Quite High
tolerance 1 73.44 Quite High
Autonomic response 1 71.44 Quite High
withdrawal 2 71.00 Quite High
Disease Link Frequency Relevance Heat
Diabetes Mellitus 5 89.04 High High
Targeted Disruption 1 88.68 High High
Opiate Addiction 1 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Injection of myricetin three times daily for three consecutive days resulted in increased expression of the glucose transporter subtype 4 (GLUT 4) in soleus muscle and in reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver; these inductions were preventable by opioid mu-receptor blockade.
Negative_regulation (preventable) of Localization (blockade) of opioid mu-receptor in muscle associated with opioid
1) Confidence 0.31 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203117 Disease Relevance 0.37 Pain Relevance 0.53
These results suggest that chronic morphine treatment leads to a decreased presence of MOR1 at the cell surface, without a significant reduction in cytoplasmic receptor density.
Negative_regulation (decreased) of Localization (presence) of MOR1 associated with morphine
2) Confidence 0.24 Published 2005 Journal Exp. Neurol. Section Abstract Doc Link 16194531 Disease Relevance 0 Pain Relevance 1.01

General Comments

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