INT130556

Context Info Confidence 0.22 First Reported 2006 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.84 Pain Relevance 0.40

small molecule metabolic process (CACNA1C) plasma membrane (CACNA1C) transmembrane transport (CACNA1C) cytoplasm (CACNA1C)

CACNA1C (Homo sapiens)

Pain Link Frequency Relevance Heat gABA 2 99.94 tolerance 6 93.80 sodium channel 5 90.44 alcohol 5 87.76 action potential duration 1 85.88 Calcium channel 1 56.40 Migraine 1 25.00 Central nervous system 1 25.00 potassium channel 3 21.04 Mexiletine 6 5.00

Disease Link Frequency Relevance Heat Syndrome 130 100.00 Sleep Disorders 61 99.76 Paralysis 7 93.08 Cv General 2 Under Development 1 90.48 Channelopathies 3 88.08 Symphalangism 2 85.60 Malignant Neoplastic Disease 4 83.44 Cv General 4 Under Development 2 71.12 Hypoglycemia 1 66.40 Cognitive Disorder 1 65.28

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

CACNA1c (LQT8) – Timothy syndrome

CACNA1c Binding (syndrome) of associated with syndrome

1) Confidence 0.22 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.14 Pain Relevance 0.15

A significant difference between these two compounds is that indiplon is 10 times more selective for the GABA-A alpha 1 subunit, which is associated with sedation, compared to the alpha 2, 3 or 5 subunits.

alpha 1 subunit Binding (associated) of associated with gaba and sleep disorders

2) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.10 Pain Relevance 0.25

Over the past decade mutations in genes encoding three ion channels, CACN1AS, SCN4A and KCNJ2, have been identified and account for at least 70% of the identified cases of PP and several allelic disorders.

CACN1AS Binding (account) of

3) Confidence 0.00 Published 2006 Journal Brain Section Abstract Doc Link 16195244 Disease Relevance 0.60 Pain Relevance 0

General Comments

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