INT130556

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Context Info
Confidence 0.22
First Reported 2006
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.84
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CACNA1C) plasma membrane (CACNA1C) transmembrane transport (CACNA1C)
cytoplasm (CACNA1C)
CACNA1C (Homo sapiens)
Pain Link Frequency Relevance Heat
gABA 2 99.94 Very High Very High Very High
tolerance 6 93.80 High High
sodium channel 5 90.44 High High
alcohol 5 87.76 High High
action potential duration 1 85.88 High High
Calcium channel 1 56.40 Quite High
Migraine 1 25.00 Low Low
Central nervous system 1 25.00 Low Low
potassium channel 3 21.04 Low Low
Mexiletine 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Syndrome 130 100.00 Very High Very High Very High
Sleep Disorders 61 99.76 Very High Very High Very High
Paralysis 7 93.08 High High
Cv General 2 Under Development 1 90.48 High High
Channelopathies 3 88.08 High High
Symphalangism 2 85.60 High High
Malignant Neoplastic Disease 4 83.44 Quite High
Cv General 4 Under Development 2 71.12 Quite High
Hypoglycemia 1 66.40 Quite High
Cognitive Disorder 1 65.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CACNA1c (LQT8) – Timothy syndrome
CACNA1c Binding (syndrome) of associated with syndrome
1) Confidence 0.22 Published 2008 Journal Orphanet J Rare Dis Section Body Doc Link PMC2474834 Disease Relevance 1.14 Pain Relevance 0.15
A significant difference between these two compounds is that indiplon is 10 times more selective for the GABA-A alpha 1 subunit, which is associated with sedation, compared to the alpha 2, 3 or 5 subunits.
alpha 1 subunit Binding (associated) of associated with gaba and sleep disorders
2) Confidence 0.14 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.10 Pain Relevance 0.25
Over the past decade mutations in genes encoding three ion channels, CACN1AS, SCN4A and KCNJ2, have been identified and account for at least 70% of the identified cases of PP and several allelic disorders.
CACN1AS Binding (account) of
3) Confidence 0.00 Published 2006 Journal Brain Section Abstract Doc Link 16195244 Disease Relevance 0.60 Pain Relevance 0

General Comments

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