INT130560

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Context Info
Confidence 0.58
First Reported 2005
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 17
Total Number 19
Disease Relevance 13.39
Pain Relevance 1.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Serpinf1) extracellular region (Serpinf1)
Anatomy Link Frequency
optic nerve 8
retina 6
eyes 4
ciliary body 3
epithelium 2
Serpinf1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pain 8 99.56 Very High Very High Very High
Inflammation 291 94.68 High High
cytokine 36 91.16 High High
Inflammatory marker 15 86.80 High High
peripheral neuropathy 1 86.32 High High
ischemia 45 82.40 Quite High
Inflammatory mediators 15 52.48 Quite High
glial activation 15 23.24 Low Low
ketamine 36 5.00 Very Low Very Low Very Low
Multiple sclerosis 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Ganglion Cysts 135 100.00 Very High Very High Very High
Pain 8 99.56 Very High Very High Very High
Hypoxia 18 99.52 Very High Very High Very High
Glaucoma 558 98.68 Very High Very High Very High
Wound Healing 3 98.52 Very High Very High Very High
Death 138 98.28 Very High Very High Very High
Cataract 30 95.08 Very High Very High Very High
INFLAMMATION 324 94.68 High High
Diabetes Mellitus 30 92.16 High High
Neuropathic Pain 1 91.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, downregulation of PEDF expression by siRNA treatment of retinal Müller cells resulted in significantly increased TNF expression [10,58].
Negative_regulation (downregulation) of Gene_expression (expression) of PEDF
1) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.98 Pain Relevance 0.21
In DBA/2J mice, semi-quantitative RT–PCR revealed significantly decreased retinal PEDF gene expression with age (Figure 2A,B).
Negative_regulation (decreased) of Gene_expression (expression) of PEDF gene
2) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.39 Pain Relevance 0
We also showed age dependent decreases in PEDF gene expression and protein in the iris/ciliary body and aqueous humor, respectively.
Negative_regulation (decreases) of Gene_expression (expression) of PEDF gene in ciliary body
3) Confidence 0.58 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.54 Pain Relevance 0.12
PEDF gene expression decreased in both the treated and untreated mice.
Negative_regulation (decreased) of Gene_expression (expression) of PEDF gene
4) Confidence 0.46 Published 2009 Journal Molecular Vision Section Abstract Doc Link PMC2779062 Disease Relevance 0.33 Pain Relevance 0.03
In the treated mice, the expression of PEDF decreased early and then increased progressively until day 14.
Negative_regulation (decreased) of Gene_expression (expression) of PEDF
5) Confidence 0.46 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.37 Pain Relevance 0
A decrease of PEDF protein expression with age in retina from DBA/2J mice was also detected by western blot; the expression of PEDF was significantly reduced at the age of 4 months, and this decrease continued to the age of 6 months (Figure 2C,D).
Negative_regulation (reduced) of Gene_expression (expression) of PEDF in retina
6) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.36 Pain Relevance 0.03
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Negative_regulation (declines) of Gene_expression (expression) of PEDF in optic nerve
7) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.38 Pain Relevance 0.24
A decrease of PEDF protein expression with age in retina from DBA/2J mice was also detected by western blot; the expression of PEDF was significantly reduced at the age of 4 months, and this decrease continued to the age of 6 months (Figure 2C,D).
Negative_regulation (decrease) of Gene_expression (expression) of PEDF protein in retina
8) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.33 Pain Relevance 0
At 6 months of age, decreased PEDF expression in the RGC layer with residual staining in the RPE layer of DBA/2J mice (Figure 3B) was detected when compared with the age-matched C57BL/6J controls (Figure 3C).


Negative_regulation (decreased) of Gene_expression (expression) of PEDF
9) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.43 Pain Relevance 0.08
Western blot analysis also showed a significant reduction of PEDF expression in the optic nerve of DBA/2J mice at 6 months of age (Figure 2E,F).
Negative_regulation (reduction) of Gene_expression (expression) of PEDF in optic nerve
10) Confidence 0.42 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.45 Pain Relevance 0.06
In contrast, the expression of PEDF in the untreated mice decreased until the late stages of angiogenesis, and peaked only at 14 days following cauterization during the process of wound healing (Table 4).
Negative_regulation (decreased) of Gene_expression (expression) of PEDF associated with wound healing
11) Confidence 0.40 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2779062 Disease Relevance 0.56 Pain Relevance 0
Reduction in PEDF gene and protein expression with age in eyes of DBA/2J mice
Negative_regulation (Reduction) of Gene_expression (expression) of PEDF gene in eyes
12) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.41 Pain Relevance 0
It has also been suggested that the lower levels of PEDF in eyes with neuroretinal dystrophy may be related to the loss of the retinal ganglion or pigment epithelial cells that synthesize PEDF [22].
Negative_regulation (loss) of Gene_expression (synthesize) of PEDF in eyes associated with ganglion cysts
13) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.42 Pain Relevance 0
Ocular PEDF gene transfection in DBA/2J mice leads to increased intraocular PEDF expression, improved retinal ganglion cell survival, and better vision
Negative_regulation (survival) of Gene_expression (expression) of PEDF in retinal ganglion cell associated with ganglion cysts
14) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.32 Pain Relevance 0
Third, PEDF transduction reduces the loss of RGC and nerve fiber layer, delays vision loss, and leads to reduced TNF, IL-18, and GFAP in the retina and optic nerve of DBA/2J mice.


Negative_regulation (reduces) of Gene_expression (transduction) of PEDF in optic nerve
15) Confidence 0.37 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.54 Pain Relevance 0.04
In NPN patients we found an expression level decrease of three pigment epithelium-derived factor (PEDF) protein isoforms.
Negative_regulation (decrease) of Gene_expression (expression) of PEDF in epithelium associated with pain
16) Confidence 0.25 Published 2005 Journal Proteomics Section Abstract Doc Link 16196102 Disease Relevance 1.08 Pain Relevance 0.73
We also showed age dependent decreases in PEDF gene expression and protein in the iris/ciliary body and aqueous humor, respectively.
Negative_regulation (decreases) of in iris Gene_expression (expression) of PEDF gene in ciliary body
17) Confidence 0.20 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.54 Pain Relevance 0.12
We demonstrate that endogenous PEDF expression in retina and optic nerve of DBA/2J mice declines with age, while PEDF transfection maintains RGC viability, inhibits TNF and IL-18 upregulation, and reduces GFAP expression.
Negative_regulation (declines) of in retina Gene_expression (expression) of PEDF in optic nerve
18) Confidence 0.14 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 1.38 Pain Relevance 0.24
Third, PEDF transduction reduces the loss of RGC and nerve fiber layer, delays vision loss, and leads to reduced TNF, IL-18, and GFAP in the retina and optic nerve of DBA/2J mice.


Negative_regulation (reduces) of in retina Gene_expression (transduction) of PEDF in optic nerve
19) Confidence 0.12 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2647972 Disease Relevance 0.54 Pain Relevance 0.04

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