INT130572

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Context Info
Confidence 0.46
First Reported 2005
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 3.24
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retinas 6
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 1 92.80 High High
imagery 1 79.40 Quite High
corticosteroid 28 18.16 Low Low
cytokine 8 6.96 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
isoflurane 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 220 100.00 Very High Very High Very High
Metastasis 4 98.94 Very High Very High Very High
Prostate Cancer 5 98.72 Very High Very High Very High
Malignant Neoplastic Disease 1 89.28 High High
Ganglion Cysts 8 85.52 High High
Diabetic Macular Edema 84 82.24 Quite High
Ocular Toxicity (including Many Sub-types) 1 76.80 Quite High
Fibromyalgia 8 75.20 Quite High
Injury 8 67.84 Quite High
Age-related Macular Degeneration 28 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The expression of another VEGF receptor, FLT-1, was unexpectedly decreased in diabetic retinas and increased following IVTA treatment.
Positive_regulation (increased) of Gene_expression (expression) of FLT-1 in retinas associated with diabetes mellitus
1) Confidence 0.46 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.49 Pain Relevance 0
TA downregulated the expression of Vegf-a and Flk-1 but upregulated the expression of Flt-1.
Positive_regulation (upregulated) of Gene_expression (expression) of Flt-1
2) Confidence 0.43 Published 2008 Journal Diabetes Section Abstract Doc Link PMC2836241 Disease Relevance 0.61 Pain Relevance 0
In contrast to our finding, increased expression of Flt-1 in the 6-month STZ-induced diabetic rat retinas was reported by Hammes et al. (31).
Positive_regulation (increased) of Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
3) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.54 Pain Relevance 0
By contrast, Flt-1 expression was decreased in early diabetic retinas but was upregulated following IVTA treatment.
Positive_regulation (upregulated) of Gene_expression (expression) of Flt-1 in retinas associated with diabetes mellitus
4) Confidence 0.43 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.71 Pain Relevance 0
Because prostate cancer metastasis involves hematogenous and lymphatic routes, we also evaluated expression of the vascular endothelial growth factor (VEGF) and receptors (VEGFR-1, VEGFR-2, and VEGFR-3) in the metastatic deposit by immunohistochemistry.
Positive_regulation (evaluated) of Gene_expression (expression) of VEGFR-1 associated with prostate cancer and metastasis
5) Confidence 0.04 Published 2005 Journal Clin Prostate Cancer Section Abstract Doc Link 16197616 Disease Relevance 0.90 Pain Relevance 0.13

General Comments

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