INT130599

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.33
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (PAICS) small molecule metabolic process (PAICS) lyase activity (PAICS)
ligase activity (PAICS)
PAICS (Homo sapiens)
Pain Link Frequency Relevance Heat
Analgesic 2 99.58 Very High Very High Very High
Multiple sclerosis 5 99.52 Very High Very High Very High
anesthesia 3 95.88 Very High Very High Very High
local anesthetic 12 94.84 High High
Opioid 1 92.00 High High
Regional anesthesia 1 53.76 Quite High
opiate 2 48.40 Quite Low
Pain 2 44.72 Quite Low
Bioavailability 9 40.16 Quite Low
depression 4 37.76 Quite Low
Disease Link Frequency Relevance Heat
Demyelinating Disease 3 99.52 Very High Very High Very High
Propionic Acidemia 3 99.06 Very High Very High Very High
Ketoacidosis 1 96.00 Very High Very High Very High
Dementia 2 95.52 Very High Very High Very High
Injury 4 93.96 High High
Attention Deficit Hyperactivity Disorder 2 91.52 High High
Vomiting 7 90.00 High High
Gastroesophageal Reflux Disease 1 89.20 High High
Relapsing-remitting Multiple Sclerosis 2 87.56 High High
Muscle Hypotonia 1 86.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Propionic acidemia is caused by mitochondrial propionyl coenzyme carboxylase deficiency.
Negative_regulation (deficiency) of carboxylase associated with propionic acidemia
1) Confidence 0.30 Published 2005 Journal Rev Esp Anestesiol Reanim Section Abstract Doc Link 16200924 Disease Relevance 1.10 Pain Relevance 0.43
3-methylcrotonyl-CoA carboxylase deficiency and severe multiple sclerosis.
Negative_regulation (deficiency) of carboxylase associated with multiple sclerosis and analgesic
2) Confidence 0.12 Published 2007 Journal Pediatr. Neurol. Section Title Doc Link 17275669 Disease Relevance 0.54 Pain Relevance 0.19
This report describes a female with isolated 3-methylcrotonyl-CoA carboxylase deficiency.
Negative_regulation (deficiency) of carboxylase
3) Confidence 0.09 Published 2007 Journal Pediatr. Neurol. Section Abstract Doc Link 17275669 Disease Relevance 0.50 Pain Relevance 0.08
Decreased hepatic gluconeogenesis can occur by hepatic lactate uptake inhibition [252], although other studies have found that metformin decreases gluconeogenic flux through pyruvate carboxylase inhibition, phosphoenolpyruvate carboxykinase activity, and, possibly through increased conversion of pyruvate to alanine [253].
Spec (possibly) Negative_regulation (inhibition) of carboxylase
4) Confidence 0.01 Published 2008 Journal Mol Cancer Section Body Doc Link PMC2615789 Disease Relevance 0.19 Pain Relevance 0

General Comments

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