INT130603

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Context Info
Confidence 0.35
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 8.52
Pain Relevance 3.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
lung 2
heart 1
body 1
Timp1 (Mus musculus)
Pain Link Frequency Relevance Heat
metalloproteinase 351 100.00 Very High Very High Very High
endometriosis 2 99.04 Very High Very High Very High
Inflammation 153 98.68 Very High Very High Very High
Dismenorea 5 98.32 Very High Very High Very High
fibrosis 69 97.60 Very High Very High Very High
Inflammatory response 22 91.28 High High
Tetrahydrobiopterin 1 67.84 Quite High
cytokine 57 66.08 Quite High
Osteoarthritis 11 55.92 Quite High
Inflammatory mediators 7 39.12 Quite Low
Disease Link Frequency Relevance Heat
Death 29 99.16 Very High Very High Very High
Stress 11 99.16 Very High Very High Very High
Endometriosis (extended) 2 99.04 Very High Very High Very High
Myocardial Infarction 96 98.88 Very High Very High Very High
INFLAMMATION 176 98.68 Very High Very High Very High
Dysmenorrhea 2 98.32 Very High Very High Very High
Pulmonary Fibrosis 36 97.60 Very High Very High Very High
Lung Cancer 4 97.60 Very High Very High Very High
Huntington's Chorea 1 97.56 Very High Very High Very High
Cognitive Disorder 4 96.76 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TIMP-3 is unique among the TIMP family in that it binds tightly to, and is found exclusively within, the ECM [91].
TIMP Binding (binds) of
1) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175049 Disease Relevance 0.20 Pain Relevance 0.08
The absence of collagen deposition in KO mice seems to be associated with an elevated MMP-9/TIMP-1 ratio in the lungs.
TIMP Binding (associated) of in lungs
2) Confidence 0.29 Published 2005 Journal Respir Res Section Abstract Doc Link PMC548519 Disease Relevance 0.35 Pain Relevance 0.08
Metalloproteinase 2 (MMP2), and tissue inhibitor of metalloproteinase 1 (TIMP1) transcript levels were determined by a ribonuclease protection assay (RiboQuant™, Becton, Dickinson and Company, Franklin Lakes, NJ).


TIMP1 Spec (determined) Binding (determined) of associated with metalloproteinase
3) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2682759 Disease Relevance 0.25 Pain Relevance 0.13
Since pathogens interact with the TIMP-MMP axis, induction of the MMP concentration and activity might be related to different species.
TIMP-MMP Spec (might) Binding (interact) of associated with metalloproteinase
4) Confidence 0.14 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 1.28 Pain Relevance 0.76
Administration of n-3 fatty acids and EPA capsules or supplements with EPA has been shown to be associated to weight stabilization, gain in lean body mass, and improvement in quality of life markers in weight losing patients with advanced pancreatic cancer.
EPA Binding (associated) of in body associated with pancreatic cancer
5) Confidence 0.12 Published 2010 Journal Curr Treat Options Oncol Section Body Doc Link PMC3016925 Disease Relevance 0.93 Pain Relevance 0
Although NTproBNP, TIMP1 and MMP 9 were associated with cardiovascular death, heart failure or both, they were not associated with re-infarction [108].
TIMP1 Binding (associated) of in heart associated with metalloproteinase, infarction, myocardial infarction and death
6) Confidence 0.12 Published 2010 Journal BMC Med Section Body Doc Link PMC2898678 Disease Relevance 0.94 Pain Relevance 0.21
MMP and TIMP according to bacteria
TIMP Binding (bacteria) of associated with metalloproteinase
7) Confidence 0.11 Published 2008 Journal BMC Pulm Med Section Body Doc Link PMC2518539 Disease Relevance 0.75 Pain Relevance 0.80
Omega-3 phospholipid supplements that combine DHA/EPA and phospholipids into the same molecule have shown marked promise in early clinical trials.
EPA Binding (combine) of
8) Confidence 0.08 Published 2007 Journal Altern Med Rev Section Abstract Doc Link 18072818 Disease Relevance 1.54 Pain Relevance 0.17
Fish oil containing high concentrations of DHA and EPA is considered a good source of ?
EPA Binding (concentrations) of
9) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 0.95 Pain Relevance 0.34
Guarcello and colleagues used EPA-enriched oral nutrition in patients with lung cancer reported a positive effects on bodyweight and quality of life.63 A similar study by Read et al suggests that nutrition intervention with EPA improves bodyweight and reduces inflammation.64 Similarly, a double-blind randomized trial using ?
EPA Binding (intervention) of in lung associated with lung cancer and inflammation
10) Confidence 0.03 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004581 Disease Relevance 1.13 Pain Relevance 0.09
[Single nucleotide polymorphism in the matrix metalloproteinases promoter is associated with susceptibility to endometriosis and adenomyosis].
matrix metalloproteinases promoter Binding (associated) of associated with endometriosis, dismenorea and metalloproteinase
11) Confidence 0.00 Published 2005 Journal Zhonghua Fu Chan Ke Za Zhi Section Title Doc Link 16202315 Disease Relevance 0.20 Pain Relevance 0.38

General Comments

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