INT130607

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2005
Negated 0
Speculated 1
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.39
Pain Relevance 1.02

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Hcrt) cytoplasm (Hcrt)
Anatomy Link Frequency
neurons 1
Hcrt (Mus musculus)
H1 (Mus musculus)
Pain Link Frequency Relevance Heat
antinociception 8 96.32 Very High Very High Very High
Antinociceptive 2 95.32 Very High Very High Very High
antagonist 3 94.96 High High
Pain 3 87.44 High High
qutenza 1 75.28 Quite High
tail-flick 1 73.80 Quite High
Neuropeptide 3 47.88 Quite Low
Disease Link Frequency Relevance Heat
Pain 1 87.44 High High
Targeted Disruption 3 85.08 High High
Nociception 1 72.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These findings suggest the possibility that orexin A may activate H1 and H2 receptors in the supraspinal levels through the release of histamine from neurons, which might attenuate the antinociceptive effects of orexin A.
orexin A Spec (may) Positive_regulation (activate) of H1 in neurons associated with antinociceptive
1) Confidence 0.59 Published 2005 Journal Pain Section Abstract Doc Link 16202530 Disease Relevance 0.39 Pain Relevance 1.02

General Comments

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