INT130616

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Context Info
Confidence 0.48
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 1.60
Pain Relevance 3.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcg) plasma membrane (Prkcg) nucleus (Prkcg)
intracellular (Prkcg) response to stress (Prkcg) cytoplasm (Prkcg)
Anatomy Link Frequency
neurons 2
Prkcg (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 153 100.00 Very High Very High Very High
withdrawal 57 99.98 Very High Very High Very High
Morphine 6 99.76 Very High Very High Very High
narcan 3 92.96 High High
intrathecal 31 91.36 High High
antagonist 27 86.12 High High
dorsal root ganglion 53 81.32 Quite High
Glutamate receptor 14 80.76 Quite High
Hyperalgesia 28 78.36 Quite High
Spinal cord 24 77.04 Quite High
Disease Link Frequency Relevance Heat
Apoptosis 51 96.80 Very High Very High Very High
Stress 19 96.24 Very High Very High Very High
Body Weight 33 89.20 High High
Ganglion Cysts 54 81.32 Quite High
Hyperalgesia 33 78.36 Quite High
INFLAMMATION 12 70.88 Quite High
Pain 18 69.68 Quite High
Injury 15 69.56 Quite High
Bone Cancer 43 68.84 Quite High
Death 11 63.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment with the PKC inhibitor (0.5 nmol/10 ?
Positive_regulation (Pretreatment) of Negative_regulation (inhibitor) of PKC associated with kinase c
1) Confidence 0.48 Published 2006 Journal Mol Pain Section Body Doc Link PMC1482680 Disease Relevance 0.22 Pain Relevance 1.00
By contrast, morphine withdrawal induced down-regulation of PKC alpha.
Positive_regulation (induced) of Negative_regulation (down-regulation) of PKC associated with kinase c, withdrawal and morphine
2) Confidence 0.32 Published 2005 Journal Eur. J. Pharmacol. Section Abstract Doc Link 16202991 Disease Relevance 0 Pain Relevance 1.29
In 13 neurons tested, incubation of PKC inhibitor bisindolylmaleimide (BIM, 1 ?
Positive_regulation (incubation) of Negative_regulation (inhibitor) of PKC in neurons associated with kinase c
3) Confidence 0.27 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 0.46 Pain Relevance 0.69
Results indicate that taurine treatment improved As-induced hepatic damages by inhibiting PKC?
Positive_regulation (induced) of Negative_regulation (inhibiting) of PKC
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2935368 Disease Relevance 0.68 Pain Relevance 0
The fourth was used for determination of PKC?
Positive_regulation (used) of Negative_regulation (determination) of PKC
5) Confidence 0.23 Published 2005 Journal Crit Care Section Body Doc Link PMC1413997 Disease Relevance 0.23 Pain Relevance 0.10

General Comments

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