INT130632

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Context Info
Confidence 0.37
First Reported 2004
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.59
Pain Relevance 0.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Pck1) nucleolus (Pck1) nucleus (Pck1)
lipid metabolic process (Pck1) cytoplasm (Pck1)
Anatomy Link Frequency
muscle 2
Pck1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Opioid 37 98.04 Very High Very High Very High
antagonist 9 95.24 Very High Very High Very High
medulla 15 86.88 High High
Kinase C 5 74.64 Quite High
fibrosis 1 13.92 Low Low
Bile 1 12.32 Low Low
narcan 7 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Calcium channel 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 111 97.84 Very High Very High Very High
Targeted Disruption 6 96.64 Very High Very High Very High
Necrosis 1 24.80 Low Low
Cirrhosis 1 14.56 Low Low
Hypertension 1 5.00 Very Low Very Low Very Low
Toxicity 1 5.00 Very Low Very Low Very Low
Body Weight 1 5.00 Very Low Very Low Very Low
Cancer 1 5.00 Very Low Very Low Very Low
Injury 1 5.00 Very Low Very Low Very Low
Polyuria 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, the enhanced gene expression of PEPCK resulting in increases in mRNA and protein levels in diabetic rats was suppressed by a 3-day repeated treatment with tetrandrine.
Positive_regulation (enhanced) of Gene_expression (expression) of PEPCK associated with diabetes mellitus
1) Confidence 0.37 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC516459 Disease Relevance 0.19 Pain Relevance 0.35
Injection of myricetin three times daily for three consecutive days resulted in increased expression of the glucose transporter subtype 4 (GLUT 4) in soleus muscle and in reduced expression of phosphoenolpyruvate carboxykinase (PEPCK) in liver; these inductions were preventable by opioid mu-receptor blockade.
Positive_regulation (resulted) of Gene_expression (expression) of PEPCK in muscle associated with opioid
2) Confidence 0.30 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16203117 Disease Relevance 0.40 Pain Relevance 0.54

General Comments

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