INT130638

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Context Info
Confidence 0.34
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.91
Pain Relevance 2.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Cxcl12) plasma membrane (Cxcl12)
Anatomy Link Frequency
monocyte 1
neurons 1
cardiocytes 1
dorsal root ganglia 1
neurite 1
Cxcl12 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
chemokine 122 100.00 Very High Very High Very High
Inflammation 5 100.00 Very High Very High Very High
neuralgia 2 99.68 Very High Very High Very High
qutenza 14 97.40 Very High Very High Very High
Sciatic nerve 14 97.12 Very High Very High Very High
dorsal root ganglion 84 96.72 Very High Very High Very High
Neuropathic pain 27 95.72 Very High Very High Very High
Nucleus accumbens 1 91.28 High High
antagonist 37 90.24 High High
Limbic system 1 89.76 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 9 100.00 Very High Very High Very High
Injury 76 98.96 Very High Very High Very High
Neuropathic Pain 37 98.82 Very High Very High Very High
Nervous System Injury 17 96.80 Very High Very High Very High
Ganglion Cysts 84 96.72 Very High Very High Very High
Infarction 31 93.24 High High
Rheumatoid Arthritis 20 80.88 Quite High
Myocardial Infarction 50 75.12 Quite High
Hyperalgesia 12 74.56 Quite High
Demyelinating Disease 6 68.08 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
(n = 5, each). * Denotes P = 0.003 vs. control or AdV.LacZ group

Effect of SDF-1 on surviving cardiocytes and angiogenesis in the heart

Regulation (control) of SDF-1 in cardiocytes
1) Confidence 0.34 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2831180 Disease Relevance 0.37 Pain Relevance 0
Hence, the observed upregulation of responses to SDF1 and MCP1 application agreed with the anatomical observations on receptor expression described above.


Regulation (responses) of SDF1
2) Confidence 0.28 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 0.43 Pain Relevance 0.46
Spatio-temporal changes of SDF1 and its CXCR4 receptor in the dorsal root ganglia following unilateral sciatic nerve injury as a model of neuropathic pain.
Regulation (changes) of SDF1 in dorsal root ganglia associated with neuralgia, nervous system injury, neuropathic pain and sciatic nerve
3) Confidence 0.27 Published 2010 Journal Histochem. Cell Biol. Section Title Doc Link 20127490 Disease Relevance 0.89 Pain Relevance 0.91
This was due to dose-dependent changes in expression at 6 h for several genes that control neurite branching and morphogenesis including Cxcl12, Notch1 and ?
Regulation (control) of Cxcl12 in neurite
4) Confidence 0.23 Published 2008 Journal BMC Genomics Section Body Doc Link PMC2626604 Disease Relevance 0.05 Pain Relevance 0.03
Previous studies of neuropathic injury in rodents have demonstrated ddC treatment induced changes in SDF1/CXCR4 signaling by neurons [22].
Regulation (changes) of SDF1 in neurons associated with injury and neuropathic pain
5) Confidence 0.12 Published 2009 Journal Mol Pain Section Body Doc Link PMC2734548 Disease Relevance 1.07 Pain Relevance 0.37
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of CXC chemokine ligand 12 in monocyte associated with chemokine and inflammation
6) Confidence 0.02 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.69

General Comments

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