INT130646

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Context Info
Confidence 0.47
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 7.67
Pain Relevance 3.48

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
monocyte 2
chondrocytes 1
endothelial cells 1
Astrocytes 1
neural 1
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 411 100.00 Very High Very High Very High
Inflammation 119 100.00 Very High Very High Very High
Opioid 3 100.00 Very High Very High Very High
Osteoarthritis 64 98.72 Very High Very High Very High
antagonist 47 96.36 Very High Very High Very High
Central nervous system 72 93.88 High High
Nucleus accumbens 2 91.28 High High
Limbic system 2 89.76 High High
Hippocampus 10 88.56 High High
COX-2 inhibitor 28 88.08 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 142 100.00 Very High Very High Very High
Herpes Simplex Virus 238 99.50 Very High Very High Very High
Mantle-cell Lymphoma 3 99.00 Very High Very High Very High
Adhesions 64 98.84 Very High Very High Very High
Osteoarthritis 71 98.72 Very High Very High Very High
Injury 10 98.72 Very High Very High Very High
Cancer 736 98.44 Very High Very High Very High
Leukemia 32 98.24 Very High Very High Very High
Metastasis 143 97.68 Very High Very High Very High
Infection 112 97.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It could be possible that a deregulated CXCR4/CXCR7/CXCL12 axis could be already evident in early stage of illness.

8.

Regulation (deregulated) of CXCL12
1) Confidence 0.47 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 0.89 Pain Relevance 0
Mendelian randomization studies could address polymorphisms in the cd34 gene itself [39] or in the cxcl12 gene, encoding the progenitor cell-regulating chemokine SDF-1?
Regulation (regulating) of SDF associated with chemokine
2) Confidence 0.44 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2901328 Disease Relevance 0.38 Pain Relevance 0.05
group demonstrated the importance of the CXCL12/CXCR4 axis in site-specific
Regulation (importance) of CXCL12
3) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.17 Pain Relevance 0.04
adult, CXCL12 and CXCR4 are involved in the homing and retention of
Regulation (involved) of CXCL12
4) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.17 Pain Relevance 0.07
Therefore, targeting the CXCR4/CXCL12 axis is attractive therapeutic approach in leukemia patients.
Regulation (targeting) of CXCL12 associated with leukemia
5) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.43 Pain Relevance 0
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of CXCL12 in monocyte associated with chemokine and inflammation
6) Confidence 0.26 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.69
Up-regulation of SDF-1 and its receptor CXCR4 was also observed during differentiation of neural stem cells into more restricted precursors [55].
Regulation (regulation) of SDF-1 in neural
7) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2719871 Disease Relevance 0.08 Pain Relevance 0.36
In the last years, several molecules able to target CXCR4 or CXCL12 have been developed to interfere with tumor growth, including pharmacological inhibitors, antagonists, and specific antibodies.
Regulation (target) of CXCL12 associated with cancer and antagonist
8) Confidence 0.21 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2798669 Disease Relevance 0.72 Pain Relevance 0.29
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of stromal cell-derived factor-1 in monocyte associated with chemokine and inflammation
9) Confidence 0.12 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.69
Chemokines (SDF-1alpha, MIP-1), opioids and tachykinins (SP, NK-A) are important G protein-coupled haematopoietic regulators.
Regulation (regulators) of SDF-1alpha associated with chemokine and opioid
10) Confidence 0.12 Published 2006 Journal Expert Opin Biol Ther Section Abstract Doc Link 16436037 Disease Relevance 0.17 Pain Relevance 0.15
In pattern four, the expression of KSHV induced GRO, RANTES and SDF-1 genes were not significantly affected by NS-398 and si-COX-2 at 4 h PI, while significant reductions were observed at 8 and 24 h PI (Figures S6C, S6D, and 5D).
Neg (not) Regulation (affected) of SDF-1 associated with herpes simplex virus
11) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.78 Pain Relevance 0.28
Three additional genes, vascular cell adhesion molecule-1 (VCAM-1), chitinase 3-like 2 (CHI3L2) and the chemokine CXCL12 were down-regulated in sheared chondrocytes, although these genes have been reported to be up-regulated in the microarray profiling of OA chondrocytes [15], [22], [23].


Regulation (regulated) of chemokine CXCL12 in chondrocytes associated with chemokine, osteoarthritis and adhesions
12) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.90 Pain Relevance 0.40
Astrocytes and endothelial cells up-regulate chemokines such as stromal cell-derived factor (SDF)-1?
Regulation (regulate) of stromal cell-derived factor in endothelial cells associated with chemokine
13) Confidence 0.03 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.39 Pain Relevance 0.22
Astrocytes and endothelial cells up-regulate chemokines such as stromal cell-derived factor (SDF)-1?
Regulation (regulate) of stromal cell-derived factor in Astrocytes associated with chemokine
14) Confidence 0.01 Published 2007 Journal Radiat Oncol Section Body Doc Link PMC1933540 Disease Relevance 0.39 Pain Relevance 0.22

General Comments

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