INT130647

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.01
Pain Relevance 1.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL12) extracellular space (CXCL12) extracellular region (CXCL12)
cell adhesion (CXCL12)
Anatomy Link Frequency
monocyte 1
neurons 1
CXCL12 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 280 100.00 Very High Very High Very High
Inflammation 79 100.00 Very High Very High Very High
Nucleus accumbens 1 94.40 High High
Limbic system 1 92.88 High High
Hippocampus 1 91.68 High High
Thalamus 1 90.64 High High
COX-2 inhibitor 25 89.80 High High
cytokine 82 80.80 Quite High
antagonist 38 78.64 Quite High
Opioid 1 44.32 Quite Low
Disease Link Frequency Relevance Heat
Herpes Simplex Virus 238 100.00 Very High Very High Very High
INFLAMMATION 91 100.00 Very High Very High Very High
Cancer 570 99.96 Very High Very High Very High
Endometrial Cancer 6 99.96 Very High Very High Very High
Metastasis 125 99.12 Very High Very High Very High
Infection 110 99.08 Very High Very High Very High
Adenocarcinoma 6 87.40 High High
Breast Cancer 70 86.32 High High
Recurrence 10 85.84 High High
Ovarian Cancer 178 85.52 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
the CXCL12/CXCR4 axis has been shown to be important in the progression and
Regulation (important) of Gene_expression (axis) of CXCL12
1) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 0.94 Pain Relevance 0.05
our appreciation of the role that CXCR4 and CXCL12 may play in cancer
Regulation (role) of Gene_expression (play) of CXCL12 associated with cancer
2) Confidence 0.39 Published 2008 Journal PPAR Research Section Body Doc Link PMC2528256 Disease Relevance 1.10 Pain Relevance 0.04
As far as endometrial cancer, studies on CXCR4 and CXCL12 expression revealed that CXCR4 is overexpressed in endometrial cancers as compared with normal tissues, whereas CXCL12 was overexpressed in normal mucosa.
Regulation (studies) of Gene_expression (expression) of CXCL12 associated with endometrial cancer
3) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Body Doc Link PMC2798669 Disease Relevance 1.35 Pain Relevance 0
In particular the imbalanced or aberrant expression of CXCL12 and its receptor CXCR4 strongly affects cancer cell proliferation, recruitment of immunosuppressive cells, neovascularization, and metastasization.
Regulation (affects) of Gene_expression (expression) of CXCL12 associated with cancer
4) Confidence 0.34 Published 2010 Journal Journal of Oncology Section Abstract Doc Link PMC2798669 Disease Relevance 0.72 Pain Relevance 0.28
Among the chemokines and their receptors that are arrayed disproportionately in glia and neurons are monocyte chemotactic protein-1/CC chemokine ligand 2 (CCL2), stromal cell-derived factor-1/CXC chemokine ligand 12 (CXCL12), fractalkine/CX3C chemokine ligand 1, interferon-gamma-inducible-protein-10/CXCL10, macrophage inflammatory protein-1alpha/CCL3, and regulated on activation, normal T cell expressed and secreted/CCL5.
Regulation (regulated) of in monocyte Gene_expression (expressed) of CXCL12 in neurons associated with chemokine and inflammation
5) Confidence 0.26 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204637 Disease Relevance 0.10 Pain Relevance 0.73
In pattern four, the expression of KSHV induced GRO, RANTES and SDF-1 genes were not significantly affected by NS-398 and si-COX-2 at 4 h PI, while significant reductions were observed at 8 and 24 h PI (Figures S6C, S6D, and 5D).
Neg (not) Regulation (affected) of Gene_expression (expression) of SDF-1 associated with herpes simplex virus
6) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2820536 Disease Relevance 0.80 Pain Relevance 0.29

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