INT130649

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Context Info
Confidence 0.36
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.38
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Cyba) mitochondrion (Cyba) oxidoreductase activity (Cyba)
Golgi apparatus (Cyba) cytoplasm (Cyba)
Cyba (Mus musculus)
Pain Link Frequency Relevance Heat
local anesthetic 24 99.80 Very High Very High Very High
lidocaine 2 93.60 High High
cytokine 11 82.20 Quite High
Inflammation 11 81.84 Quite High
GABAergic 9 50.00 Quite Low
ketamine 4 40.24 Quite Low
Hippocampus 13 13.08 Low Low
imagery 6 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
interneuron 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Brain Injury 53 98.80 Very High Very High Very High
Cancer 2 85.24 High High
INFLAMMATION 11 81.84 Quite High
Cognitive Disorder 35 50.00 Quite Low
Aging 23 33.80 Quite Low
Death 5 28.52 Quite Low
Apoptosis 4 27.88 Quite Low
Injury 4 25.56 Quite Low
Disease 8 5.00 Very Low Very Low Very Low
Contusions 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Classically activated BV-2 increased gp91phox and p22phox
Positive_regulation (increased) of p22phox
1) Confidence 0.36 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2917406 Disease Relevance 0.16 Pain Relevance 0
B to induce Nox2 or p22phox has not been previously addressed.
Positive_regulation (induce) of p22phox
2) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2678193 Disease Relevance 0.17 Pain Relevance 0.08
Thus, tetracaine and the other local anesthetics inhibit by disparate mechanisms, but all the local anesthetics impaired up-regulation of cytochrome b558 and all impaired priming of NADPH oxidase by LPS.
Positive_regulation (up-regulation) of cytochrome b558 associated with local anesthetic
3) Confidence 0.06 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204644 Disease Relevance 0 Pain Relevance 0.91
Local anesthetics inhibited LPS-induced up-regulation of cytochrome b558 but not LPS-induced translocation of p47phox.
Positive_regulation (up-regulation) of cytochrome b558 associated with local anesthetic
4) Confidence 0.04 Published 2005 Journal J. Leukoc. Biol. Section Abstract Doc Link 16204644 Disease Relevance 0.05 Pain Relevance 1.08

General Comments

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