INT130669

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Context Info
Confidence 0.25
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.69
Pain Relevance 0.44

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (CYP2C9) oxidoreductase activity (CYP2C9) endoplasmic reticulum (CYP2C9)
Anatomy Link Frequency
bone marrow 2
2B7 2
reticulum 2
CYP2C9 (Homo sapiens)
Pain Link Frequency Relevance Heat
depression 1 100.00 Very High Very High Very High
antidepressant 1 98.14 Very High Very High Very High
Morphine 3 97.68 Very High Very High Very High
cINOD 1 85.88 High High
Codeine 2 25.00 Low Low
Disease Link Frequency Relevance Heat
Stress 5 100.00 Very High Very High Very High
Depression 1 100.00 Very High Very High Very High
Shock 1 97.40 Very High Very High Very High
Muscle Disease 1 96.40 Very High Very High Very High
Adverse Drug Reaction 1 79.68 Quite High
Hepatocellular Cancer 1 75.00 Quite High
Toxicity 1 45.84 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Spec (investigated) Regulation (Effects) of Gene_expression (expressed) of CYP2C9 in 2B7 associated with morphine
1) Confidence 0.25 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25
P450 2C9 overexpression induced endoplasmic reticulum (ER) stress and regulated genes implicated in the unfolded protein response (UPR) as heat shock protein (HSP) (we studied particurlarly HSPA5 and HSPB1) and in the endoplasmic reticulum associated degradation (ERAD) system as Sec61 and ubiquitin and proteasome pathways.
Regulation (regulated) of Gene_expression (overexpression) of P450 2C9 in reticulum associated with stress and shock
2) Confidence 0.22 Published 2009 Journal Chem. Res. Toxicol. Section Abstract Doc Link 19445531 Disease Relevance 0.41 Pain Relevance 0.09
Examples include genotyping of CYP2D6 in the context of antidepressant therapy, analysis of TPMT variants for the prediction of mercaptopurine-induced bone marrow depression, VKORC1 and CYP2C9 analyses for a better control of anticoagulant administration and the SLCO1B1 variant in the context of statin-induced myopathies.
Spec (analyses) Regulation (control) of Spec (analyses) Gene_expression (depression) of CYP2C9 in bone marrow associated with antidepressant, depression and muscle disease
3) Confidence 0.17 Published 2010 Journal Dtsch. Med. Wochenschr. Section Abstract Doc Link 20101557 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

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