INT130671

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Context Info
Confidence 0.43
First Reported 2004
Last Reported 2009
Negated 0
Speculated 1
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.27
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

oxidoreductase activity (Cyp1a2) endoplasmic reticulum (Cyp1a2) enzyme binding (Cyp1a2)
response to stress (Cyp1a2)
Anatomy Link Frequency
2B7 2
Cyp1a2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 8 99.88 Very High Very High Very High
Morphine 3 97.68 Very High Very High Very High
tolerance 2 72.08 Quite High
alcohol 1 17.80 Low Low
Inflammation 4 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Crohn's disease 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 37 99.68 Very High Very High Very High
Autoimmune Hepatitis 169 94.52 High High
Liver Disease 9 92.20 High High
Primary Sclerosing Cholangitis 7 85.84 High High
Autoimmune Disease 10 78.32 Quite High
Hepatitis 18 60.56 Quite High
Hepatitis C Virus Infection 43 53.68 Quite High
Infection 17 53.36 Quite High
Chronic Hepatitis 14 44.16 Quite Low
Injury 7 42.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The administration of ACET down-regulated CYP1A2 and CYP2B1 expression in CD rats, while up-regulating them in NF rats.
Regulation (regulated) of Gene_expression (expression) of CYP1A2 associated with paracetamol
1) Confidence 0.43 Published 2009 Journal J Appl Toxicol Section Abstract Doc Link 18798224 Disease Relevance 0 Pain Relevance 0.59
Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell microsomal membranes were investigated using morphine as a substrate.
Spec (investigated) Regulation (Effects) of Gene_expression (expressed) of CYP1A2 in 2B7 associated with morphine
2) Confidence 0.17 Published 2005 Journal Biol. Pharm. Bull. Section Abstract Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25
CYP1A2, CYP2A6, CYP21, CYP17, and CYP11A1), that are expressed in organs affected by the disease process.
Regulation (affected) of Gene_expression (expressed) of CYP1A2 associated with disease
3) Confidence 0.10 Published 2004 Journal J Autoimmune Dis Section Body Doc Link PMC544946 Disease Relevance 1.27 Pain Relevance 0.04

General Comments

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