INT130672

Context Info Confidence 0.22 First Reported 2005 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.38 Pain Relevance 2.71

endoplasmic reticulum (Ugt2b7) molecular_function (Ugt2b7) cellular_component (Ugt2b7) biological_process (Ugt2b7)

Anatomy Link Frequency 2B7 1 Ugt2b7 (Rattus norvegicus)

Pain Link Frequency Relevance Heat Analgesic 33 100.00 Morphine 25 100.00 opioid receptor 17 100.00 balanced analgesia 1 87.92 Oxycodone 35 81.80 Opioid 32 79.36 Codeine 8 76.96 Pain 29 75.00 tramadol 1 73.60 MU agonist 6 65.36

Disease Link Frequency Relevance Heat Renal Insufficiency 1 90.96 Toxicity 1 83.60 Post-operative Nausea 3 80.12 Pain 55 75.00 Dizziness 3 29.20 Vomiting 28 5.00 Pruritus 7 5.00 Constipation 7 5.00 Post Operative Pain 6 5.00 Headache 3 5.00

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Anatomy

Negation

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Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4.

UDP-glucuronosyltransferase 2B7 Binding (Modulation) of in 2B7

1) Confidence 0.22 Published 2005 Journal Biol. Pharm. Bull. Section Title Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25

-diphospho-glucuronosyl transferases (UGTs) UGT1A9 and UGT2B7, which are responsible for approximately 55% of tapentadol metabolism in humans.41 The major metabolite of tapentadol, tapentadol-O-glucuronide, has no activity at opioid receptors, synaptosomal reuptake systems, or other binding sites.35 Morphine is likewise primarily metabolized by hepatic glucuronidation via UGT2B7 to morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G).42 Morphine-3-glucuronide has no analgesic activity, but M6G has an affinity for the ?

UGT2B7 Binding (affinity) of associated with analgesic, opioid receptor and morphine

2) Confidence 0.18 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004637 Disease Relevance 0.38 Pain Relevance 2.47

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