INT130672

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Context Info
Confidence 0.22
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.38
Pain Relevance 2.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endoplasmic reticulum (Ugt2b7) molecular_function (Ugt2b7) cellular_component (Ugt2b7)
biological_process (Ugt2b7)
Anatomy Link Frequency
2B7 1
Ugt2b7 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Analgesic 33 100.00 Very High Very High Very High
Morphine 25 100.00 Very High Very High Very High
opioid receptor 17 100.00 Very High Very High Very High
balanced analgesia 1 87.92 High High
Oxycodone 35 81.80 Quite High
Opioid 32 79.36 Quite High
Codeine 8 76.96 Quite High
Pain 29 75.00 Quite High
tramadol 1 73.60 Quite High
MU agonist 6 65.36 Quite High
Disease Link Frequency Relevance Heat
Renal Insufficiency 1 90.96 High High
Toxicity 1 83.60 Quite High
Post-operative Nausea 3 80.12 Quite High
Pain 55 75.00 Quite High
Dizziness 3 29.20 Quite Low
Vomiting 28 5.00 Very Low Very Low Very Low
Pruritus 7 5.00 Very Low Very Low Very Low
Constipation 7 5.00 Very Low Very Low Very Low
Post Operative Pain 6 5.00 Very Low Very Low Very Low
Headache 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Modulation of UDP-glucuronosyltransferase 2B7 function by cytochrome P450s in vitro: differential effects of CYP1A2, CYP2C9 and CYP3A4.
UDP-glucuronosyltransferase 2B7 Binding (Modulation) of in 2B7
1) Confidence 0.22 Published 2005 Journal Biol. Pharm. Bull. Section Title Doc Link 16204972 Disease Relevance 0 Pain Relevance 0.25
-diphospho-glucuronosyl transferases (UGTs) UGT1A9 and UGT2B7, which are responsible for approximately 55% of tapentadol metabolism in humans.41 The major metabolite of tapentadol, tapentadol-O-glucuronide, has no activity at opioid receptors, synaptosomal reuptake systems, or other binding sites.35 Morphine is likewise primarily metabolized by hepatic glucuronidation via UGT2B7 to morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G).42 Morphine-3-glucuronide has no analgesic activity, but M6G has an affinity for the ?
UGT2B7 Binding (affinity) of associated with analgesic, opioid receptor and morphine
2) Confidence 0.18 Published 2010 Journal Journal of pain research Section Body Doc Link PMC3004637 Disease Relevance 0.38 Pain Relevance 2.47

General Comments

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