INT130689

Context Info Confidence 0.13 First Reported 2006 Last Reported 2006 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.59 Pain Relevance 0.24

cytoplasm (CA2, ATF4) nucleoplasm (ATF4) lyase activity (CA2) DNA binding (ATF4) microtubule organizing center (ATF4) response to stress (CA2)

CA2 (Homo sapiens) ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat cINOD 6 65.56

Disease Link Frequency Relevance Heat Apoptosis 7 90.32 Cancer 4 76.36 Stomach Cancer 1 64.48 INFLAMMATION 1 48.16

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that the Ca2+-dependent activation of the PERK-eIF2alpha-ATF4 pathway is involved in the upregulation of ER chaperones by celecoxib.

Ca2 Positive_regulation (activation) of ATF4

1) Confidence 0.13 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.59 Pain Relevance 0.24

General Comments

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