INT130698

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Context Info
Confidence 0.36
First Reported 2006
Last Reported 2007
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.58
Pain Relevance 0.42

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5)
nucleus (HSPA5) protein binding, bridging (HSPA5)
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 9 68.64 Quite High
Disease Link Frequency Relevance Heat
Stress 2 85.72 High High
Apoptosis 14 82.80 Quite High
Cancer 5 79.44 Quite High
Toxicity 1 76.16 Quite High
Renal Cancer 4 75.00 Quite High
Stomach Cancer 1 67.56 Quite High
INFLAMMATION 2 51.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Celecoxib increased the intracellular Ca2+ concentration, while 1,2-bis(2-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid, an intracellular Ca2+ chelator, inhibited the upregulation of GRP78 and ATF4.
Negative_regulation (inhibited) of Positive_regulation (upregulation) of GRP78
1) Confidence 0.36 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.74 Pain Relevance 0.36
Selective inhibitors of ERK, p38 MAPK, and JNK suppressed the induction of GRP78, CHOP, and PPAR-beta, attenuated indomethacin-induced cytotoxicity and reduced increased caspase activity.
Negative_regulation (suppressed) of Positive_regulation (induction) of GRP78
2) Confidence 0.26 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 0.83 Pain Relevance 0.06

General Comments

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