INT130700

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Context Info
Confidence 0.75
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 16
Disease Relevance 11.55
Pain Relevance 2.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5)
nucleus (HSPA5) protein binding, bridging (HSPA5)
Anatomy Link Frequency
chondrocytes 2
margin 1
reticulum 1
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
dopamine receptor 3 99.64 Very High Very High Very High
qutenza 22 99.10 Very High Very High Very High
Serotonin 2 98.82 Very High Very High Very High
GABA receptor 2 98.40 Very High Very High Very High
Glutamate receptor 6 97.90 Very High Very High Very High
Neurotransmitter 4 97.32 Very High Very High Very High
cINOD 21 95.12 Very High Very High Very High
Inflammation 27 94.64 High High
Osteoarthritis 54 92.80 High High
ischemia 1 90.64 High High
Disease Link Frequency Relevance Heat
Stress 40 99.82 Very High Very High Very High
Metabolic Syndrome 64 99.76 Very High Very High Very High
Apoptosis 42 98.96 Very High Very High Very High
Albuminuria 4 98.16 Very High Very High Very High
Death 30 97.76 Very High Very High Very High
Diabetes Mellitus 104 97.20 Very High Very High Very High
Toxicity 3 96.76 Very High Very High Very High
Ocular Toxicity (including Many Sub-types) 4 96.24 Very High Very High Very High
INFLAMMATION 42 94.64 High High
Coronary Artery Disease 164 93.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Gene_expression (levels) of GRP78 associated with stress and qutenza
1) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Gene_expression (levels) of Bip associated with stress and qutenza
2) Confidence 0.75 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
On the other hand, suppression of GRP78 expression by siRNA drastically stimulated cellular apoptosis and production of CHOP in the presence of celecoxib.
Gene_expression (expression) of GRP78 associated with apoptosis
3) Confidence 0.66 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.50 Pain Relevance 0.05
Overexpression of GRP78 partially suppressed the apoptosis and induction of CHOP in the presence of celecoxib and this suppression was stimulated by coexpression of either ERdj3 or ERdj4.
Gene_expression (Overexpression) of GRP78 associated with apoptosis
4) Confidence 0.66 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.58 Pain Relevance 0.17
A number of previous reports have described the positive modulation of GS on ER proteins, including GRP78 expression [52], but this is the first time that such modulation was found to arise from GS treatment in chondrocytes; thus interestingly suggesting an specific mechanism of action for the putative anti-inflammatory effect of GS in OA.
Gene_expression (expression) of GRP78 in chondrocytes associated with inflammation and osteoarthritis
5) Confidence 0.66 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.62 Pain Relevance 0.27
Among the four well-known neurotransmitter pathways (glutamate receptor signaling, GABA receptor signaling, serotonin receptor signaling and dopamine receptor signaling), GRB2 appeared in all the four pathways and HSPA5 in three pathways, and the interaction between GRB2 and HSPA5 appeared in three pathways.
Gene_expression (appeared) of HSPA5 associated with neurotransmitter, dopamine receptor, gaba receptor, glutamate receptor and serotonin
6) Confidence 0.62 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2894047 Disease Relevance 0.28 Pain Relevance 0.32
Real-time PCR assays demonstrated the GS-dependent upregulation of GRP78 gene expression, showing remarkable increases of almost 30-fold in GS-treated chondrocytes (P < 0.05, n = 6, age range: 55 to 63 years), and even slightly higher with combined GS and CS treatment (Figure 4A).
Gene_expression (expression) of GRP78 gene in chondrocytes
7) Confidence 0.57 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.28 Pain Relevance 0.11
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Gene_expression (expression) of GRP78 in reticulum associated with stress
8) Confidence 0.47 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
Localization patterns of Nuc, COX-2 and GRP-78 systematically matched with each other, suggesting that Nuc and COX-2 both reside in the Golgi and ER structures [44].
Gene_expression (patterns) of GRP-78
9) Confidence 0.29 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2373884 Disease Relevance 0 Pain Relevance 0
The majority of OSBP1 coincided with the ER marker GRP78, detected in fractions 11 and 12 (Figure 4B, right panel and 4C).
Gene_expression (detected) of GRP78
10) Confidence 0.24 Published 2008 Journal Mol Neurodegener Section Body Doc Link PMC2323375 Disease Relevance 0 Pain Relevance 0
The BIP study (The BIP Study Group 2000; also described separately in the following section) comprised 3090 patients allocated to bezafibrate (400 mg/day) or placebo.
Gene_expression (study) of BIP
11) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.35 Pain Relevance 0
Bezafibrate therapy: recent data from the BIP trial
Gene_expression (trial) of BIP
12) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.26 Pain Relevance 0
First, LDL-C levels in BIP were in a moderately high range at baseline (averaging 149 mg/dL), necessitating a relatively large prescription rate of “off-trial” lipid lowering therapies, mainly in the placebo group (15% of placebo-allocated patients received active lipid therapy by the end of the study), thereby attenuating the margin of difference in outcome between the placebo and active treatment groups.
Gene_expression (levels) of BIP in margin
13) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 0.46 Pain Relevance 0
The BIP study (The BIP Study Group 2000; also described separately in the following section) comprised 3090 patients allocated to bezafibrate (400 mg/day) or placebo.
Gene_expression (study) of BIP
14) Confidence 0.21 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464751 Disease Relevance 1.35 Pain Relevance 0
Hek293 cells were tested for the expression of each chaperone tested (figure 1b) and Bip, Calnexin, Calreticulin, ERp57, HSP70, PDI and GRP94 were all expressed.
Gene_expression (expression) of Bip
15) Confidence 0.19 Published 2010 Journal J Mol Signal Section Body Doc Link PMC2954983 Disease Relevance 0 Pain Relevance 0
Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon.
Gene_expression (expression) of glucose regulated protein 78 associated with stress
16) Confidence 0.09 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.25 Pain Relevance 0.19

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