INT130702

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Context Info
Confidence 0.59
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 7.53
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

unfolded protein binding (HSPA5) endoplasmic reticulum (HSPA5) ATPase activity (HSPA5)
nucleus (HSPA5) protein binding, bridging (HSPA5)
Anatomy Link Frequency
chondrocytes 4
reticulum 4
HSPA5 (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 22 99.32 Very High Very High Very High
cINOD 15 95.44 Very High Very High Very High
Inflammation 17 94.96 High High
Osteoarthritis 54 94.52 High High
ischemia 1 90.96 High High
cytokine 16 90.84 High High
Pain 8 5.00 Very Low Very Low Very Low
Analgesic 2 5.00 Very Low Very Low Very Low
metalloproteinase 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 41 99.98 Very High Very High Very High
Apoptosis 40 98.96 Very High Very High Very High
Death 10 98.20 Very High Very High Very High
Toxicity 4 97.16 Very High Very High Very High
INFLAMMATION 22 94.96 High High
Osteoarthritis 54 94.52 High High
Cv General 4 Under Development 1 90.96 High High
Cancer 10 90.56 High High
Disease 12 90.04 High High
Renal Cancer 8 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overexpression of GRP78 partially suppressed the apoptosis and induction of CHOP in the presence of celecoxib and this suppression was stimulated by coexpression of either ERdj3 or ERdj4.
Positive_regulation (Overexpression) of Gene_expression (Overexpression) of GRP78 associated with apoptosis
1) Confidence 0.59 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.58 Pain Relevance 0.17
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Gene_expression (levels) of Bip associated with stress and qutenza
2) Confidence 0.49 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.
Positive_regulation (increasing) of Gene_expression (levels) of GRP78 associated with stress and qutenza
3) Confidence 0.49 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.23 Pain Relevance 0.74
A number of previous reports have described the positive modulation of GS on ER proteins, including GRP78 expression [52], but this is the first time that such modulation was found to arise from GS treatment in chondrocytes; thus interestingly suggesting an specific mechanism of action for the putative anti-inflammatory effect of GS in OA.
Positive_regulation (modulation) of Gene_expression (expression) of GRP78 in chondrocytes associated with inflammation and osteoarthritis
4) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.63 Pain Relevance 0.27
Real-time PCR assays demonstrated the GS-dependent upregulation of GRP78 gene expression, showing remarkable increases of almost 30-fold in GS-treated chondrocytes (P < 0.05, n = 6, age range: 55 to 63 years), and even slightly higher with combined GS and CS treatment (Figure 4A).
Positive_regulation (upregulation) of Gene_expression (expression) of GRP78 gene in chondrocytes
5) Confidence 0.42 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945029 Disease Relevance 0.28 Pain Relevance 0.11
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Positive_regulation (activation) of Gene_expression (expression) of GRP78 in reticulum associated with stress
6) Confidence 0.31 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
Indomethacin treatment was associated with increased expression of glucose-regulated protein 78 (GRP78) and C/EBP homologus protein (CHOP) and activation of ATF-6, characteristics of endoplasmic reticulum stress.
Positive_regulation (increased) of Gene_expression (expression) of GRP78 in reticulum associated with stress
7) Confidence 0.31 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17341418 Disease Relevance 1.16 Pain Relevance 0.22
Pranoprofen inhibited ER stress-induced glucose regulated protein 78 (GRP78) expression, an ER-localized molecular chaperon.
Positive_regulation (induced) of Gene_expression (expression) of glucose regulated protein 78 associated with stress
8) Confidence 0.06 Published 2009 Journal Neurochem. Int. Section Abstract Doc Link 19114067 Disease Relevance 1.25 Pain Relevance 0.19

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