INT130704

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 11
Disease Relevance 5.29
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4)
cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)
Anatomy Link Frequency
reticulum 1
ATF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 20 98.72 Very High Very High Very High
cINOD 32 98.04 Very High Very High Very High
Inflammation 35 97.44 Very High Very High Very High
addiction 3 75.72 Quite High
adenocard 4 36.64 Quite Low
Nicotine 27 5.00 Very Low Very Low Very Low
COX2 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
Glutamate 4 5.00 Very Low Very Low Very Low
COX-2 inhibitor 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 42 99.56 Very High Very High Very High
Stress 209 97.44 Very High Very High Very High
INFLAMMATION 46 97.44 Very High Very High Very High
Cancer 168 96.72 Very High Very High Very High
Stomach Cancer 12 95.00 High High
Colon Cancer 160 94.24 High High
Apoptosis 85 86.28 High High
Leukemia 12 77.28 Quite High
Adhesions 16 70.48 Quite High
Metastasis 7 64.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors.
Gene_expression (expression) of ATF4 associated with inflammation and cinod
1) Confidence 0.78 Published 2009 Journal Cell Cycle Section Abstract Doc Link 19887912 Disease Relevance 0.85 Pain Relevance 0.10
Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150.
Gene_expression (expression) of ATF4
2) Confidence 0.62 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17167033 Disease Relevance 0.73 Pain Relevance 0.08
Suppression of ATF4 expression by small interfering RNA (siRNA) partially inhibited the celecoxib-dependent upregulation of GRP78.
Gene_expression (expression) of ATF4
3) Confidence 0.59 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.74 Pain Relevance 0.42
Effect of CS on ATF4 levels and expression of ATF4-dependent genes
Gene_expression (expression) of ATF4-dependent
4) Confidence 0.52 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04
Effect of CS on ATF4 levels and expression of ATF4-dependent genes
Gene_expression (expression) of ATF4
5) Confidence 0.52 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04
The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.
Gene_expression (transfection) of ATF4 in reticulum associated with stress
6) Confidence 0.51 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.81 Pain Relevance 0.33
-tubulin cat#2144), GeneTex, Inc., San Antonio, TX (eIF2A (phospho S52)Cat # GTX24837), Santa Cruz Biotechnology Inc., Santa Cruz, CA (ATF3 cat#sc-188, ATF4 cat#sc-200), Abcam Inc., Cambridge, MA (GAPDH cat#ab8245, ?
Gene_expression (cat) of ATF4
7) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0
For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.
Gene_expression (expression) of ATF4 associated with aspirin
8) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.76 Pain Relevance 0.46
Figure 2 shows the expression profile of ATF4 and ASNS in response to curcumin.
Gene_expression (expression) of ATF4
9) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.20 Pain Relevance 0
Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation.
Gene_expression (expression) of ATF4
10) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0
Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points.
Gene_expression (expression) of ATF4
11) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.15 Pain Relevance 0

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