INT130704
From wiki-pain
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Sentences Mentioned In
Key: | Protein | Mutation | Event | Anatomy | Negation | Speculation | Pain term | Disease term |
Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors. | |||||||||||||||
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Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150. | |||||||||||||||
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Suppression of ATF4 expression by small interfering RNA (siRNA) partially inhibited the celecoxib-dependent upregulation of GRP78. | |||||||||||||||
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Effect of CS on ATF4 levels and expression of ATF4-dependent genes | |||||||||||||||
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Effect of CS on ATF4 levels and expression of ATF4-dependent genes | |||||||||||||||
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The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response. | |||||||||||||||
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-tubulin cat#2144), GeneTex, Inc., San Antonio, TX (eIF2A (phospho S52)Cat # GTX24837), Santa Cruz Biotechnology Inc., Santa Cruz, CA (ATF3 cat#sc-188, ATF4 cat#sc-200), Abcam Inc., Cambridge, MA (GAPDH cat#ab8245, ? | |||||||||||||||
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For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin. | |||||||||||||||
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Figure 2 shows the expression profile of ATF4 and ASNS in response to curcumin. | |||||||||||||||
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Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation. | |||||||||||||||
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Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points. | |||||||||||||||
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General Comments
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