INT130704

Context Info Confidence 0.78 First Reported 2004 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 9 Total Number 11 Disease Relevance 5.29 Pain Relevance 1.45

nucleoplasm (ATF4) DNA binding (ATF4) microtubule organizing center (ATF4) cytoplasm (ATF4) nucleus (ATF4) cytoskeleton (ATF4)

Anatomy Link Frequency reticulum 1 ATF4 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 20 98.72 cINOD 32 98.04 Inflammation 35 97.44 addiction 3 75.72 adenocard 4 36.64 Nicotine 27 5.00 COX2 4 5.00 metalloproteinase 4 5.00 Glutamate 4 5.00 COX-2 inhibitor 3 5.00

Disease Link Frequency Relevance Heat Hypoxia 42 99.56 Stress 209 97.44 INFLAMMATION 46 97.44 Cancer 168 96.72 Stomach Cancer 12 95.00 Colon Cancer 160 94.24 Apoptosis 85 86.28 Leukemia 12 77.28 Adhesions 16 70.48 Metastasis 7 64.04

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Elevated expression of ATF4 is associated with resistance to current chemotherapeutic drugs including DNA-interactive and damaging agents, nonsteroidal anti-inflammatory drugs and proteasome inhibitors.

Gene_expression (expression) of ATF4 associated with inflammation and cinod

1) Confidence 0.78 Published 2009 Journal Cell Cycle Section Abstract Doc Link 19887912 Disease Relevance 0.85 Pain Relevance 0.10

Both the ATF4 and ATF6 pathways were activated by celecoxib, and suppression of ATF4 and ATF6 mRNA expression by small interfering RNA (siRNA) inhibited the celecoxib-dependent up-regulation of ORP150.

Gene_expression (expression) of ATF4

2) Confidence 0.62 Published 2007 Journal Mol. Pharmacol. Section Abstract Doc Link 17167033 Disease Relevance 0.73 Pain Relevance 0.08

Suppression of ATF4 expression by small interfering RNA (siRNA) partially inhibited the celecoxib-dependent upregulation of GRP78.

Gene_expression (expression) of ATF4

3) Confidence 0.59 Published 2006 Journal Oncogene Section Abstract Doc Link 16205636 Disease Relevance 0.74 Pain Relevance 0.42

Effect of CS on ATF4 levels and expression of ATF4-dependent genes

Gene_expression (expression) of ATF4-dependent

4) Confidence 0.52 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04

Effect of CS on ATF4 levels and expression of ATF4-dependent genes

Gene_expression (expression) of ATF4

5) Confidence 0.52 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0.41 Pain Relevance 0.04

The celecoxib-mediated up-regulation of S100P was suppressed by the transfection of cells with small interfering RNA for activating transcription factor 4 (ATF4), a transcription factor involved in the endoplasmic reticulum stress response.

Gene_expression (transfection) of ATF4 in reticulum associated with stress

6) Confidence 0.51 Published 2009 Journal J. Biol. Chem. Section Abstract Doc Link 19073601 Disease Relevance 0.81 Pain Relevance 0.33

-tubulin cat#2144), GeneTex, Inc., San Antonio, TX (eIF2A (phospho S52)Cat # GTX24837), Santa Cruz Biotechnology Inc., Santa Cruz, CA (ATF3 cat#sc-188, ATF4 cat#sc-200), Abcam Inc., Cambridge, MA (GAPDH cat#ab8245, ?

Gene_expression (cat) of ATF4

7) Confidence 0.45 Published 2008 Journal BMC Cancer Section Body Doc Link PMC2527015 Disease Relevance 0 Pain Relevance 0

For example, expression of ASNS, ATF4 and MTHFD2 was upregulated by sulindac and expression of BUB1B and PDCD2 was downregulated by aspirin.

Gene_expression (expression) of ATF4 associated with aspirin

8) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.76 Pain Relevance 0.46

Figure 2 shows the expression profile of ATF4 and ASNS in response to curcumin.

Gene_expression (expression) of ATF4

9) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.20 Pain Relevance 0

Indeed, curcumin was found to upregulate expression of ATF4 at the early time points, consistent with its role as an initiator of the curcumin effect through gene transcription modulation.

Gene_expression (expression) of ATF4

10) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.21 Pain Relevance 0

Induction of ATF4 expression at the early time points is followed by induction of expression of ASNS at the same and later time points.

Gene_expression (expression) of ATF4

11) Confidence 0.42 Published 2004 Journal J Carcinog Section Body Doc Link PMC421747 Disease Relevance 0.15 Pain Relevance 0

General Comments

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