INT130705

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 50
Total Number 52
Disease Relevance 38.85
Pain Relevance 2.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (TFAM) nucleus (TFAM) DNA binding (TFAM)
Anatomy Link Frequency
respiratory 3
lymph node 2
Caco-2 1
skeletal muscle 1
T cells 1
TFAM (Homo sapiens)
Pain Link Frequency Relevance Heat
opioid receptor 9 98.64 Very High Very High Very High
Multiple sclerosis 131 96.72 Very High Very High Very High
Cannabinoid 8 91.48 High High
cytokine 166 88.84 High High
cINOD 17 84.68 Quite High
Arthritis 4 83.44 Quite High
Inflammation 236 82.72 Quite High
Pain 5 82.04 Quite High
mu opioid receptor 1 81.08 Quite High
antagonist 50 78.60 Quite High
Disease Link Frequency Relevance Heat
Cancer 951 100.00 Very High Very High Very High
Endometrial Cancer 207 100.00 Very High Very High Very High
Endometroid Carcinoma 828 99.84 Very High Very High Very High
Skin Cancer 49 99.80 Very High Very High Very High
Carcinoma 460 99.76 Very High Very High Very High
Stress 203 99.56 Very High Very High Very High
Hypoxia 106 99.10 Very High Very High Very High
Apoptosis 247 99.00 Very High Very High Very High
Diabetes Mellitus 137 98.16 Very High Very High Very High
Metastasis 211 98.12 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mtTFA expression of nonendometrioid carcinomas was not associated with the clinicopathologic variables and prognosis of the patients.
Gene_expression (expression) of mtTFA associated with carcinoma
1) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.04 Pain Relevance 0
This study investigated the correlation between the expression of mtTFA and the clinicopathological profile of the patients with endometrial carcinoma and thus found the mtTFA expression to be a useful maker for progression of the tumors and the poor prognosis of the patients in endometrioid adenocarcinomas.


Gene_expression (expression) of mtTFA associated with endometroid carcinoma, cancer and endometrial cancer
2) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.95 Pain Relevance 0
This study investigated the relationship between the immunohistochemical expression of mtTFA and various clinicopathological variables in 276 endometrial carcinomas, including 245 endometrioid adenocarcinomas and 31 nonendometrioid carcinomas (21 serous carcinomas and 10 clear cell adenocarcinomas).
Gene_expression (expression) of mtTFA associated with endometroid carcinoma, clear cell adenocarcinoma, carcinoma and endometrial cancer
3) Confidence 0.77 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 0.79 Pain Relevance 0
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
4) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.42 Pain Relevance 0
It is interesting that correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas.
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
5) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.54 Pain Relevance 0
mtTFA expression
Gene_expression (expression) of mtTFA
6) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.89 Pain Relevance 0
There is no literature concerning with the incidence of mtDNA mutation in endometrioid adenocarcinomas or correlation between mtTFA expression and mutation of mtDNA.
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
7) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.09 Pain Relevance 0
The cell lines of radio-resistant oral squamous cell carcinoma strongly expressed mtTFA in comparison to those of the radio-sensitive oral squamous cell carcinoma [17].
Gene_expression (expressed) of mtTFA associated with skin cancer
8) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.50 Pain Relevance 0
The degree of correlation between the p53 and mtTFA expression was evaluated using the Pearson test.
Gene_expression (expression) of mtTFA
9) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 0.29 Pain Relevance 0
The mtTFA labeling index of endometrioid adenocarcinomas ranged from 0% to 98%, with a median value of 32%, which was selected as the cut-off point for mtTFA expression.
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
10) Confidence 0.77 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.07 Pain Relevance 0
Correlation analysis between mtTFA and p53 expression by using the Pearson test showed significant correlation in endometrioid adenocarcinomas (P?
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
11) Confidence 0.77 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.26 Pain Relevance 0
This study investigated the correlation between the expression of mtTFA and the clinicopathological profile of the patients with endometrial carcinoma and thus found the mtTFA expression to be a useful maker for progression of the tumors and the poor prognosis of the patients in endometrioid adenocarcinomas.


Gene_expression (expression) of mtTFA associated with endometroid carcinoma, cancer and endometrial cancer
12) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.10 Pain Relevance 0
In contrast, no correlation between clinicopathologic variables and mtTFA expression was found in nonendometrioid carcinomas.
Gene_expression (expression) of mtTFA associated with carcinoma
13) Confidence 0.77 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.25 Pain Relevance 0
After incubation of this antibody with the excess of synthesized peptides of mtTFA, the positive immunostaining was almost abolished (Fig. 2).
Gene_expression (synthesized) of mtTFA
14) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.81 Pain Relevance 0
In conclusion, the positive mtTFA expression is a useful maker for the progression of the tumors and the poor prognosis of the patients in endometrioid adenocarcinomas.
Gene_expression (expression) of mtTFA associated with endometroid carcinoma and cancer
15) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.48 Pain Relevance 0
The mtTFA expression in endometrioid adenocarcinomas was significantly associated with the surgical stage, myometrial invasion, lymphovascular space invasion, cervical invasion, and lymph node metastasis.
Gene_expression (expression) of mtTFA in lymph node associated with endometroid carcinoma and metastasis
16) Confidence 0.77 Published 2010 Journal Virchows Arch Section Abstract Doc Link PMC2852529 Disease Relevance 1.08 Pain Relevance 0
In contrast, the mtTFA expression of endometrioid adenocarcinomas was significantly associated with the clinicopathologic variables and prognosis of the patients.
Gene_expression (expression) of mtTFA associated with endometroid carcinoma
17) Confidence 0.77 Published 2010 Journal Virchows Arch Section Body Doc Link PMC2852529 Disease Relevance 1.02 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM (the principal transcription factor involved in regulating mtDNA transcription) and PPARGC1A (Figure 1A and 1B), suggesting an induction of mitochondrial biogenesis.
Gene_expression (expression) of TFAM
18) Confidence 0.71 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0 Pain Relevance 0
Six months of caloric restriction caused an increase in the expression levels of TFAM and PPARGC1A and induced mitochondrial biogenesis.
Gene_expression (expression) of TFAM
19) Confidence 0.71 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.31 Pain Relevance 0
To investigate the molecular mechanism(s) by which caloric restriction lowered oxygen consumption per unit of FFM, we determined expression of genes involved in mitochondrial biogenesis including PPARGC1A, PPARGC1B, NRF1, and TFAM in skeletal muscle—a metabolically active organ [43] reported to be involved in the aging process [44] and oxidative stress [6].
Spec (determined) Gene_expression (expression) of TFAM in skeletal muscle associated with stress and aging
20) Confidence 0.71 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC1808482 Disease Relevance 0.33 Pain Relevance 0

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