INT130727

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Context Info
Confidence 0.32
First Reported 2000
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 5.95
Pain Relevance 0.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Anatomy Link Frequency
neuronal 1
eyes 1
muscle 1
C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Neuronal excitability 2 99.56 Very High Very High Very High
qutenza 9 96.40 Very High Very High Very High
alcohol 7 92.08 High High
c fibre 4 89.68 High High
dorsal root ganglion 4 72.56 Quite High
depression 6 66.80 Quite High
Neurotransmitter 10 65.68 Quite High
anesthesia 14 62.92 Quite High
Acupuncture 2 52.08 Quite High
spinal inflammation 4 50.00 Quite Low
Disease Link Frequency Relevance Heat
Cough 273 100.00 Very High Very High Very High
Injury 224 98.40 Very High Very High Very High
Increased Venous Pressure Under Development 74 97.96 Very High Very High Very High
Aspiration Pneumonia 47 97.32 Very High Very High Very High
Burns 84 95.80 Very High Very High Very High
Sleep Disorders 10 92.76 High High
Pressure Volume 2 Under Development 43 78.88 Quite High
Shock 11 73.32 Quite High
Ganglion Cysts 4 71.60 Quite High
Hypercapnia 61 70.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The aim of the present study was to investigate the effect of defocused CO2 laser on blood perfusion and to correlate it with temperature in skin and underlying muscle in anaesthetized horses.
Spec (investigate) Regulation (effect) of CO2 in muscle
1) Confidence 0.32 Published 2006 Journal Acta Vet Scand Section Abstract Doc Link PMC1618964 Disease Relevance 0.09 Pain Relevance 0
The physiological effect of the applied CO2 laser irradiation is related to the activation of warmth and heat receptors and afferents; cutaneous thermosensitive A?
Regulation (effect) of CO2 associated with increased venous pressure under development
2) Confidence 0.32 Published 2006 Journal Acta Vet Scand Section Body Doc Link PMC1618964 Disease Relevance 0.49 Pain Relevance 0.30
The experimental protocol was the following:

• to derive baseline conditions, the subjects were allowed to rest for about 10 minutes in a dimmed and quiet room, laying comfortably in a supine position with eyes closed and breathing room air; • when we observed stable signals (i.e. when the concentrations of O2Hb and CO2Hb and the CBFV did not show remarkable variations from their mean values), the subjects were instructed to perform a breath – holding after a normal inspiration; • at the end of the apnea, the subjects were asked to rest for 5 minutes and we collected signals related to the post – stimulus conditions.


Regulation (concentrations) of CO2Hb in eyes associated with sleep disorders
3) Confidence 0.27 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.15 Pain Relevance 0
Reproducibility of the capsaicin cough challenge studied by Dicpinigaitis demonstrated that the change in log C2 in the short term group was 0.27 ± 0.29 mM 75% of patients studied showed a within 1 doubling dose change in C2 and 95% were within 2 doubling doses.
Regulation (change) of C2 associated with qutenza and cough
4) Confidence 0.24 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.97 Pain Relevance 0.27
In the present study, C2 and C5 are same value in 1 subject in control group and 5 subjects in the patients with aspiration pneumonia.


Regulation (value) of C2 associated with cough and aspiration pneumonia
5) Confidence 0.23 Published 2008 Journal Cough Section Body Doc Link PMC2600632 Disease Relevance 2.62 Pain Relevance 0.03
Clearly local metabolic factors that alter the position of the haemaglobin CO2 dissociation curve could result in changes in measured gastric CO2 in the absence of any alteration in local CO2 production.
Regulation (changes) of CO2
6) Confidence 0.19 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.26 Pain Relevance 0
Clearly local metabolic factors that alter the position of the haemaglobin CO2 dissociation curve could result in changes in measured gastric CO2 in the absence of any alteration in local CO2 production.
Regulation (position) of CO2
7) Confidence 0.14 Published 2000 Journal Crit Care Section Body Doc Link PMC137256 Disease Relevance 0.27 Pain Relevance 0
g of protein was electrophoresed on a 4 to 12% NuPAGE Novex Bis-Tris gel, and for the C2 proteasome subunit, 50 ?
Regulation (electrophoresed) of C2
8) Confidence 0.11 Published 2008 Journal American Journal of Physiology - Endocrinology and Metabolism Section Body Doc Link PMC2536736 Disease Relevance 0 Pain Relevance 0
Domankevitz and Nishioka167 demonstrated that under appropriate conditions, a scanned cw CO2 laser could ablate tissue with a zone of residual thermal injury less than 200 ?
Regulation (ablate) of CO2 associated with injury
9) Confidence 0.10 Published 2005 Journal Journal of Burns and Wounds Section Body Doc Link PMC1501116 Disease Relevance 0.97 Pain Relevance 0
Oxygen saturation values are available immediately, while TC-CO2 values are available after a 2-3 min calibration time.


Regulation (values) of TC-CO2
10) Confidence 0.08 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0 Pain Relevance 0.11
During TLV, the TC-CO2 value was closer to the actual PaCO2 in 10 patients, the ET-CO2 value was closer in 2 patients and there was no difference in 3 patients (P=NS).
Regulation (value) of TC-CO2
11) Confidence 0.08 Published 2007 Journal Journal of Minimal Access Surgery Section Body Doc Link PMC2910382 Disease Relevance 0 Pain Relevance 0
In addition, Balestrino and Somjen suggest that pH changes might not be the only effect of CO2 impacting neuronal excitability.
Spec (might) Regulation (effect) of CO2 in neuronal associated with neuronal excitability
12) Confidence 0.06 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.12 Pain Relevance 0.09
Changes in C2C correlated significantly with changes in ESR (r = 0.51, p = 0.04) and CRP (r = 0.48, p = 0.048).
Regulation (Changes) of C2C
13) Confidence 0.02 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0
Significant changes in C2C were not evident in the infliximab observational cohort, although significant reductions were noted in levels of MMP-3 (p = 0.04) and MMP-1 (p = 0.02) at 14 weeks that were not observed in the etanercept group.
Regulation (changes) of C2C
14) Confidence 0.02 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0

General Comments

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