INT130729

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Context Info
Confidence 0.42
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 7.59
Pain Relevance 3.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 20
cartilage 4
ANFH 2
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 479 99.84 Very High Very High Very High
Inflammation 101 98.48 Very High Very High Very High
cytokine 116 96.80 Very High Very High Very High
metalloproteinase 206 95.24 Very High Very High Very High
Pain 34 94.08 High High
Leflunomide 1 88.36 High High
Arthritis 50 70.84 Quite High
imagery 1 53.32 Quite High
spinal inflammation 2 50.00 Quite Low
Etanercept 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Osteoarthritis 586 99.84 Very High Very High Very High
Hypertrophy 242 99.20 Very High Very High Very High
INFLAMMATION 109 98.48 Very High Very High Very High
Pressure And Volume Under Development 1 98.44 Very High Very High Very High
Disease 58 97.40 Very High Very High Very High
Aging 11 96.00 Very High Very High Very High
Knee Osteoarthritis 25 95.96 Very High Very High Very High
Pain 33 94.08 High High
Apoptosis 39 88.96 High High
Lung Cancer 1 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effect of added PGE2 and the interrelationships we observed in control cultures suggests an interesting dynamic in which PGE2 in the range 0 to 70 pg/ml released from OA specimens is associated with the suppression of collagen cleavage.
Negative_regulation (suppression) of Protein_catabolism (cleavage) of collagen in cleavage associated with osteoarthritis
1) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.34 Pain Relevance 0.17
It is unclear why very low exogenous concentrations of 10 pg/ml PGE2 can suppress collagen cleavage when cultures already contain up to 70 pg/ml PGE2.
Negative_regulation (suppress) of Protein_catabolism (cleavage) of collagen in cleavage
2) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.55 Pain Relevance 0.29
Thus, repeated application of PGE2 with each medium change may have been enough to decrease collagen cleavage.
Negative_regulation (decrease) of Protein_catabolism (cleavage) of collagen in cleavage
3) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.52 Pain Relevance 0.28
Downregulation of collagen cleavage was not accompanied by significant changes in GAG release in explants cultured in the presence of 10 pg/ml PGE2 (Figure 2).
Negative_regulation (Downregulation) of Protein_catabolism (cleavage) of collagen in cleavage
4) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.48 Pain Relevance 0.29
Collagen cleavage was downregulated by exogenous PGE2 at concentrations as low as 0.1 pg/ml (data not shown) and 1 pg/ml in one of four patients (Figure 1b).
Negative_regulation (downregulated) of Protein_catabolism (cleavage) of Collagen in cleavage
5) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.27 Pain Relevance 0.14
These studies show that PGE2 at concentrations much lower than those generated in inflammation is often chondroprotective in that it is frequently capable of selectively suppressing the excessive collagenase-mediated COL2A1 cleavage found in OA cartilage.
Negative_regulation (suppressing) of Protein_catabolism (cleavage) of COL2A1 in cleavage associated with inflammation and osteoarthritis
6) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.82 Pain Relevance 0.22
We have shown that PGE2 at low concentrations in OA cartilage can downregulate collagenase-dependent COL2A1 cleavage and the associated hypertrophy.
Negative_regulation (downregulate) of Protein_catabolism (cleavage) of COL2A1 in cleavage associated with hypertrophy and osteoarthritis
7) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.71 Pain Relevance 0.35
However, in most examined cartilages and as shown by the group analyses, significant downregulation of collagen cleavage was observed at 10 pg/ml PGE2 in these four individual patients (Figure 1e) and in a larger cohort of 13 other patients (Figure 1f).
Negative_regulation (downregulation) of Protein_catabolism (cleavage) of collagen in cartilages
8) Confidence 0.42 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.30 Pain Relevance 0.15
Only early decompression in I degree of ANFH according to ARCO classification may stop a further progress of disease.
Negative_regulation (decompression) of Protein_catabolism (degree) of ANFH in ANFH associated with disease
9) Confidence 0.41 Published 2010 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 20695186 Disease Relevance 0.76 Pain Relevance 0.27
Our experimental system containing added 10 pg/ml PGE2 produced chondroprotection on OA articular cartilage in that it downregulated collagen cleavage and the expression of genes associated with collagen cleavage, proinflammatory cytokines and hypertrophy.
Negative_regulation (downregulated) of Protein_catabolism (cleavage) of collagen in cleavage associated with hypertrophy, osteoarthritis and cytokine
10) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.62 Pain Relevance 0.19
Together these results draw attention to the capacity of exogenous PGE2 to suppress collagen cleavage and PGE2 content.
Negative_regulation (suppress) of Protein_catabolism (cleavage) of collagen in cleavage
11) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.57 Pain Relevance 0.30
Downregulation of excessive collagen cleavage in OA by suppression of expression of a hypertrophic phenotype could therefore be a promising approach in controlling the disease severity.
Negative_regulation (Downregulation) of Protein_catabolism (cleavage) of collagen in cleavage associated with disease and osteoarthritis
12) Confidence 0.41 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.97 Pain Relevance 0.29
These include decreased degradation of type II collagen and increased turnover of aggrecan.
Negative_regulation (decreased) of Protein_catabolism (degradation) of type II collagen
13) Confidence 0.12 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0
In a parallel observation, another study found that catechins from green tea inhibited the degradation of human cartilage proteoglycan and type II collagen, and selectively inhibited ADAMTS-1, ADAMTS-4, and ADAMTS-5 [22,23].
Negative_regulation (inhibited) of Protein_catabolism (degradation) of type II collagen in cartilage
14) Confidence 0.05 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2888220 Disease Relevance 0.41 Pain Relevance 0.25
Improved clinical assessments were observed and degradation of collagen type II was prevented with pentosan treatment.


Negative_regulation (prevented) of Protein_catabolism (degradation) of collagen type II
15) Confidence 0.04 Published 2010 Journal BMC Clin Pharmacol Section Body Doc Link PMC2873929 Disease Relevance 0.24 Pain Relevance 0.15

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