INT130730

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Context Info
Confidence 0.57
First Reported 2005
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 11
Total Number 13
Disease Relevance 3.81
Pain Relevance 1.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (C2) extracellular space (C2) extracellular region (C2)
Anatomy Link Frequency
neuronal 1
nerve 1
adult brain 1
C2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Pain 35 100.00 Very High Very High Very High
analgesia 3 99.98 Very High Very High Very High
nociceptor 27 94.64 High High
Clonidine 4 89.36 High High
anesthesia 40 86.48 High High
Versed 5 77.72 Quite High
qutenza 12 70.16 Quite High
Ultiva 16 61.60 Quite High
TRP channel 1 57.12 Quite High
spinal inflammation 2 50.00 Quite Low
Disease Link Frequency Relevance Heat
Hypercapnia 238 100.00 Very High Very High Very High
Cough 188 100.00 Very High Very High Very High
Pain 34 100.00 Very High Very High Very High
Hyperoxia 8 99.18 Very High Very High Very High
Sleep Disorders 24 95.44 Very High Very High Very High
Increased Venous Pressure Under Development 18 76.20 Quite High
Anxiety Disorder 1 75.00 Quite High
Nociception 2 59.72 Quite High
Knee Osteoarthritis 2 55.60 Quite High
Low Back Pain 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, the rate of postoperative analgesia decreased significantly in group C 2 and C 4 compared to group M.
Negative_regulation (decreased) of C 2 associated with analgesia
1) Confidence 0.57 Published 2009 Journal Biosci Trends Section Abstract Doc Link 20103833 Disease Relevance 0.42 Pain Relevance 0.77
However, In contrast when volunteers were retested with the Mefar dosimeter there was a larger reduction in C2 measured -5.89, 2.57.
Negative_regulation (reduction) of C2 associated with cough
2) Confidence 0.51 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.99 Pain Relevance 0.07
By means of near – infrared spectroscopy (NIRS) it is possible to continuously monitor the local concentrations of oxygenated (O2Hb) and reduced (CO2Hb) in the adult brain.
Spec (possible) Negative_regulation (reduced) of CO2Hb in adult brain
3) Confidence 0.51 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.06 Pain Relevance 0
Even though the four patterns are different, there are common features that are characteristic of an intact autoregulation mechanism: i) after a very short initial phase, the VMR pattern is always comprised into the region delimited by the first and third quadrant bisectors; ii) CO2Hb is kept at baseline concentrations during the VMR phase, or, in some subjects, may decrease its concentration (graph C); iii) the final portion of the BH is characterized by a plateau region during which O2Hb is almost constant and CO2Hb tends to increase (a brief plateau region is observable in graph D, this pattern is relative to the subject that showed the minimum and shorter plateau phase).
Spec (may) Negative_regulation (decrease) of CO2Hb
4) Confidence 0.42 Published 2006 Journal J Neuroengineering Rehabil Section Body Doc Link PMC1544341 Disease Relevance 0.08 Pain Relevance 0
In all cases, visualization of the C-1, C-2 and C-3 nerve roots was unfeasible.
Negative_regulation (visualization) of C-2 in nerve
5) Confidence 0.41 Published 2010 Journal Surg Radiol Anat Section Body Doc Link 20082079 Disease Relevance 0 Pain Relevance 0
How then does one type of inhalation challenge cause a larger reduction in subsequent C2 and the other not?
Negative_regulation (reduction) of C2 associated with cough
6) Confidence 0.37 Published 2010 Journal Cough Section Body Doc Link PMC2925329 Disease Relevance 0.96 Pain Relevance 0.13
Previous studies have investigated the CO2 laser evoked responses (latencies and pain intensities) from 2 different A?
Spec (investigated) Negative_regulation (intensities) of CO2 associated with pain
7) Confidence 0.10 Published 2010 Journal Biomed Eng Online Section Body Doc Link PMC2991325 Disease Relevance 0.23 Pain Relevance 0.45
Overall, the decrease in neuronal baseline activity during moderate hypercapnia (i.e., 6% CO2) was accompanied by an increase in hemodynamic signals; this is opposite to the pattern of changes observed during stimulation.
Negative_regulation (decrease) of CO2 in neuronal associated with hypercapnia
8) Confidence 0.07 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.30 Pain Relevance 0
However, recalculating baseline CMRO2 using CBF and BOLD changes induced by hyperoxia also presented in their study, yields a decrease in baseline CMRO2 in both CO2 challenges in agreement with our results.
Negative_regulation (decrease) of CO2 associated with hyperoxia
9) Confidence 0.05 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.25 Pain Relevance 0.21
In addition, the magnitudes of local field potentials in the gamma and beta frequency ranges and MUA were significantly reduced at the 6% CO2 level with respect to their baseline values.
Negative_regulation (reduced) of CO2
10) Confidence 0.05 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.29 Pain Relevance 0
CMRO2 for 10% inspired CO2.
Negative_regulation (inspired) of CO2
11) Confidence 0.05 Published 2008 Journal Cerebral Cortex (New York, NY) Section Body Doc Link PMC2567427 Disease Relevance 0.19 Pain Relevance 0.07
RESULTS: There was a significant reduction in levels of C2C (p = 0.005) and a significant increase in the 846 epitope (p = 0.01) in patients who received etanercept compared to placebo controls.
Negative_regulation (reduction) of C2C
12) Confidence 0.05 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0
The group of patients receiving 1 mg of sCT exhibited significant decreases in the levels of CTX-II, C2C, and MMP-13.
Negative_regulation (decreases) of C2C
13) Confidence 0.02 Published 2006 Journal Arthritis Rheum. Section Body Doc Link 17009253 Disease Relevance 0.06 Pain Relevance 0

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