INT130731

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Context Info
Confidence 0.96
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 21.86
Pain Relevance 9.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (COL2A1) extracellular region (COL2A1) cytoplasm (COL2A1)
Anatomy Link Frequency
cleavage 24
cartilage 8
chondrocytes 3
articular cartilage 1
joint 1
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Osteoarthritis 1633 99.84 Very High Very High Very High
metalloproteinase 499 99.48 Very High Very High Very High
Inflammation 254 97.54 Very High Very High Very High
rheumatoid arthritis 249 96.80 Very High Very High Very High
cytokine 248 96.80 Very High Very High Very High
imagery 232 95.96 Very High Very High Very High
Pain 119 94.08 High High
Inflammatory response 6 93.28 High High
Leflunomide 2 88.36 High High
Arthritis 167 74.52 Quite High
Disease Link Frequency Relevance Heat
Osteoarthritis 1542 99.84 Very High Very High Very High
Osteoporosis 74 99.76 Very High Very High Very High
Hypertrophy 470 99.66 Very High Very High Very High
Osteophyte 26 98.36 Very High Very High Very High
Obesity 57 98.08 Very High Very High Very High
Pressure And Volume Under Development 16 97.68 Very High Very High Very High
INFLAMMATION 271 97.54 Very High Very High Very High
Disease 205 97.40 Very High Very High Very High
Rheumatoid Arthritis 258 96.80 Very High Very High Very High
Knee Osteoarthritis 351 95.96 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We used this information to determine whether the addition of exogenous PGE2 concentrations in this range would influence the cleavage of COL2A1 by collagenases in human OA explants.
Protein_catabolism (cleavage) of COL2A1 in cleavage associated with osteoarthritis
1) Confidence 0.96 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.28 Pain Relevance 0.14
Only early decompression in I degree of ANFH according to ARCO classification may stop a further progress of disease.
Protein_catabolism (degree) of ANFH in ANFH associated with disease
2) Confidence 0.86 Published 2010 Journal Chir Narzadow Ruchu Ortop Pol Section Abstract Doc Link 20695186 Disease Relevance 0.76 Pain Relevance 0.27
-chymotrypsin to solubilize denatured collagen including the carboxy-terminal neoepitope COL2–3/4C short (C1,2C) epitope generated by the cleavage of COL2A1 by collagenase.
Protein_catabolism (cleavage) of COL2A1 in cleavage
3) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.09 Pain Relevance 0.05
Our experimental system containing added 10 pg/ml PGE2 produced chondroprotection on OA articular cartilage in that it downregulated collagen cleavage and the expression of genes associated with collagen cleavage, proinflammatory cytokines and hypertrophy.
Protein_catabolism (cleavage) of collagen in cleavage associated with hypertrophy, osteoarthritis and cytokine
4) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.62 Pain Relevance 0.19
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-?

Protein_catabolism (cleavage) of COL2A1 in cleavage associated with hypertrophy and osteoarthritis
5) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206385 Disease Relevance 0.90 Pain Relevance 0.05
Prostaglandin PGE2 at very low concentrations suppresses collagen cleavage in cultured human osteoarthritic articular cartilage: this involves a decrease in expression of proinflammatory genes, collagenases and COL10A1, a gene linked to chondrocyte hypertrophy

Suppression of type II collagen (COL2A1) cleavage by transforming growth factor (TGF)-?

Protein_catabolism (cleavage) of type II collagen in cleavage associated with hypertrophy and osteoarthritis
6) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Title Doc Link PMC2206385 Disease Relevance 0.90 Pain Relevance 0.05
COL2A1 cleavage was measured by ELISA.
Protein_catabolism (cleavage) of COL2A1 in cleavage
7) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.91 Pain Relevance 0.04
Together these results draw attention to the capacity of exogenous PGE2 to suppress collagen cleavage and PGE2 content.
Protein_catabolism (cleavage) of collagen in cleavage
8) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.57 Pain Relevance 0.30
Downregulation of excessive collagen cleavage in OA by suppression of expression of a hypertrophic phenotype could therefore be a promising approach in controlling the disease severity.
Protein_catabolism (cleavage) of collagen in cleavage associated with disease and osteoarthritis
9) Confidence 0.85 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.96 Pain Relevance 0.29
We have shown that PGE2 at low concentrations in OA cartilage can downregulate collagenase-dependent COL2A1 cleavage and the associated hypertrophy.
Protein_catabolism (cleavage) of COL2A1 in cleavage associated with hypertrophy and osteoarthritis
10) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.70 Pain Relevance 0.35
Osteoarthritic changes in articular cartilage involve progressive proteolytic degradation of its extracellular matrix, composed mainly of type II collagen (COL2A1) and aggrecan, eventually leading to a loss of the cartilage.
Protein_catabolism (degradation) of type II collagen in extracellular matrix associated with osteoarthritis
11) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.81 Pain Relevance 0.49
Finally, it is important to recognize the fact that in the presence of additional physiological amounts of PGE2, not only are OA chondrocytes often capable of reverting to a more normal phenotype, as reflected by studies of gene expression and matrix collagen degradation, but osteoblastic differentiation, detected by alkaline phosphatase activity, is also enhanced [35,40].
Protein_catabolism (degradation) of collagen in chondrocytes associated with osteoporosis and osteoarthritis
12) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.75 Pain Relevance 0.34
Collagen cleavage was downregulated by exogenous PGE2 at concentrations as low as 0.1 pg/ml (data not shown) and 1 pg/ml in one of four patients (Figure 1b).
Protein_catabolism (cleavage) of Collagen in cleavage
13) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.27 Pain Relevance 0.14
In control OA cultures (no additions) there was an inverse relationship between PGE2 concentration (range 0 to 70 pg/ml) and collagen cleavage.
Protein_catabolism (cleavage) of collagen in cleavage associated with osteoarthritis
14) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.95 Pain Relevance 0.21
Downregulation of collagen cleavage was not accompanied by significant changes in GAG release in explants cultured in the presence of 10 pg/ml PGE2 (Figure 2).
Protein_catabolism (cleavage) of collagen in cleavage
15) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.48 Pain Relevance 0.29
Here we test the hypothesis that PGE2 alone can inhibit collagen degradation in OA articular cartilage, and provide evidence in support of it.


Protein_catabolism (degradation) of collagen in articular cartilage associated with osteoarthritis
16) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.61 Pain Relevance 0.28
Thus, repeated application of PGE2 with each medium change may have been enough to decrease collagen cleavage.
Protein_catabolism (cleavage) of collagen in cleavage
17) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.52 Pain Relevance 0.28
However, in most examined cartilages and as shown by the group analyses, significant downregulation of collagen cleavage was observed at 10 pg/ml PGE2 in these four individual patients (Figure 1e) and in a larger cohort of 13 other patients (Figure 1f).
Protein_catabolism (cleavage) of collagen in cartilages
18) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.30 Pain Relevance 0.15
These studies show that PGE2 at concentrations much lower than those generated in inflammation is often chondroprotective in that it is frequently capable of selectively suppressing the excessive collagenase-mediated COL2A1 cleavage found in OA cartilage.
Protein_catabolism (cleavage) of COL2A1 in cleavage associated with inflammation and osteoarthritis
19) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC2206385 Disease Relevance 0.76 Pain Relevance 0.22
The effect of added PGE2 and the interrelationships we observed in control cultures suggests an interesting dynamic in which PGE2 in the range 0 to 70 pg/ml released from OA specimens is associated with the suppression of collagen cleavage.
Protein_catabolism (cleavage) of collagen in cleavage associated with osteoarthritis
20) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2206385 Disease Relevance 0.34 Pain Relevance 0.17

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