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Context Info
Confidence 0.36
First Reported 2003
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.58
Pain Relevance 0.47

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (MMP14)
Anatomy Link Frequency
cartilage 1
MMP14 (Homo sapiens)
Pain Link Frequency Relevance Heat
palliative 44 96.08 Very High Very High Very High
metalloproteinase 68 77.08 Quite High
spinal inflammation 2 50.00 Quite Low
Etanercept 1 50.00 Quite Low
Arthritis 5 32.56 Quite Low
rheumatoid arthritis 16 10.16 Low Low
Osteoarthritis 15 5.00 Very Low Very Low Very Low
Inflammation 7 5.00 Very Low Very Low Very Low
cytokine 6 5.00 Very Low Very Low Very Low
Potency 5 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 66 97.40 Very High Very High Very High
Metastasis 47 94.64 High High
Hepatocellular Cancer 58 93.16 High High
Arthropathy 4 89.68 High High
Prostate Cancer 35 86.20 High High
Arthritis 16 82.40 Quite High
Disease 17 80.36 Quite High
Osteolysis 4 79.00 Quite High
Lifespan 8 67.92 Quite High
Low Back Pain 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.
MT1-MMP Binding (alteration) of associated with cancer
1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.19 Pain Relevance 0.44
That effect was abrogated by pharmacologic inhibition of mt1-mmp activity and by osteoprotegerin, a soluble decoy receptor of the osteoclastogenic receptor activator of nuclear factor ?
mt1-mmp Binding (activity) of
2) Confidence 0.11 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.14 Pain Relevance 0
We measured serum matrix metalloproteinase-1 (MMP-1), MMP-3, human cartilage glycoprotein-39 (YKL-40), and cartilage oligomeric matrix protein by ELISA at the same timepoints.
matrix metalloproteinase-1 Binding (measured) of in cartilage
3) Confidence 0.10 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0
MMP-2 and MMP-14 can also cleave collagen.
MMP-14 Binding (collagen) of
4) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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