INT130732

Context Info Confidence 0.36 First Reported 2003 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 2.58 Pain Relevance 0.47

cytoplasm (MMP14)

Anatomy Link Frequency cartilage 1 MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat palliative 44 96.08 metalloproteinase 68 77.08 spinal inflammation 2 50.00 Etanercept 1 50.00 Arthritis 5 32.56 rheumatoid arthritis 16 10.16 Osteoarthritis 15 5.00 Inflammation 7 5.00 cytokine 6 5.00 Potency 5 5.00

Disease Link Frequency Relevance Heat Cancer 66 97.40 Metastasis 47 94.64 Hepatocellular Cancer 58 93.16 Arthropathy 4 89.68 Prostate Cancer 35 86.20 Arthritis 16 82.40 Disease 17 80.36 Osteolysis 4 79.00 Lifespan 8 67.92 Low Back Pain 2 50.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The alteration of endostatin (a potent angiogenesis inhibitor) and MT1-MMP (an activator of MMP2) was minor, which indicated that elevated tumor VEGF and increased MMP2 activity were not directly due to endostatin and MT1-MMP, whose detailed molecular mechanism remains to be elucidated.

MT1-MMP Binding (alteration) of associated with cancer

1) Confidence 0.36 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2976755 Disease Relevance 1.19 Pain Relevance 0.44

That effect was abrogated by pharmacologic inhibition of mt1-mmp activity and by osteoprotegerin, a soluble decoy receptor of the osteoclastogenic receptor activator of nuclear factor ?

mt1-mmp Binding (activity) of

2) Confidence 0.11 Published 2008 Journal Current Oncology Section Body Doc Link PMC2528310 Disease Relevance 1.14 Pain Relevance 0

We measured serum matrix metalloproteinase-1 (MMP-1), MMP-3, human cartilage glycoprotein-39 (YKL-40), and cartilage oligomeric matrix protein by ELISA at the same timepoints.

matrix metalloproteinase-1 Binding (measured) of in cartilage

3) Confidence 0.10 Published 2005 Journal J. Rheumatol. Section Body Doc Link 16206346 Disease Relevance 0 Pain Relevance 0

MMP-2 and MMP-14 can also cleave collagen.

MMP-14 Binding (collagen) of

4) Confidence 0.05 Published 2003 Journal Arthritis Res Ther Section Body Doc Link PMC154424 Disease Relevance 0.25 Pain Relevance 0.04

General Comments

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