INT13074

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Context Info
Confidence 0.19
First Reported 1991
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.86
Pain Relevance 0.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NKX2-1) anatomical structure formation involved in morphogenesis (NKX2-1) nucleus (NKX2-1)
DNA binding (NKX2-1)
Anatomy Link Frequency
thyroid 1
neurons 1
smooth muscle cell 1
NKX2-1 (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 6 99.44 Very High Very High Very High
antagonist 4 92.80 High High
agonist 1 92.16 High High
qutenza 6 91.36 High High
Dysuria 1 79.84 Quite High
Inflammation 2 76.16 Quite High
Neuropeptide 1 71.12 Quite High
c fibre 1 65.72 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 2 93.56 High High
Small Cell Lung Cancer 5 92.48 High High
Carcinoma 1 81.68 Quite High
INFLAMMATION 2 76.16 Quite High
Shock 1 75.52 Quite High
Dyspnea 1 59.44 Quite High
Cough 1 58.72 Quite High
Pain 1 5.00 Very Low Very Low Very Low
Hiatal Hernia 1 5.00 Very Low Very Low Very Low
Disease 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemistry of the tumorectomy and autopsy specimens was positive for cytokeratins, neuron-specific enolase, synaptophysin, CD56, KIT and PDGFRA, and negative for chromogranin and thyroid transcriptional factor-1.
Positive_regulation (negative) of thyroid transcriptional factor-1 in thyroid
1) Confidence 0.19 Published 2009 Journal Pathol. Int. Section Abstract Doc Link 19351368 Disease Relevance 0.59 Pain Relevance 0.08
Although the existence of species differences, the conclusion that bronchial smooth muscle contraction is mainly related to activation of NK-2 receptors on bronchial smooth muscle cell has been drawn.
Positive_regulation (activation) of NK-2 in smooth muscle cell
2) Confidence 0.06 Published 1991 Journal Life Sci. Section Abstract Doc Link 1660952 Disease Relevance 0.08 Pain Relevance 0.44
In vitro functional assays are consistent with potent competitive antagonism of substance P-(SP) or neurokinin A-(NKA) induced [3H]-inositol phosphate accumulation in NK-1 or NK-2 monoreceptor cell lines with pA2 values of 8.19 and 8.67, respectively.
Positive_regulation (induced) of NK-2 associated with substance p
3) Confidence 0.05 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8627566 Disease Relevance 0.19 Pain Relevance 0.35
CONCLUSIONS & INFERENCES: Longitudinal smooth muscle contraction induced by trypsin involves capsaicin-sensitive neurons and subsequent activation of NK-2, which is identical to the pathway involved in acid-induced LSM contraction and oesophageal shortening.
Positive_regulation (activation) of NK-2 in neurons
4) Confidence 0.01 Published 2010 Journal Neurogastroenterol. Motil. Section Body Doc Link 19740117 Disease Relevance 0 Pain Relevance 0

General Comments

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