INT130751

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Context Info
Confidence 0.39
First Reported 2005
Last Reported 2005
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

CYP3A (Homo sapiens)
Pain Link Frequency Relevance Heat
Bioavailability 5 98.86 Very High Very High Very High
methadone 8 97.24 Very High Very High Very High
Opioid 1 43.68 Quite Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast to its pharmacokinetics humans, methadone has a short elimination half-life, rapid clearance, and low oral bioavailability in dogs and the extent of absorption is not affected by inhibition of CYP3A, p-gp, and gastric acid secretion.
Negative_regulation (inhibition) of Localization (secretion) of CYP3A associated with methadone and bioavailability
1) Confidence 0.39 Published 2005 Journal J. Vet. Pharmacol. Ther. Section Abstract Doc Link 16207309 Disease Relevance 0 Pain Relevance 0.68

General Comments

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