INT130754

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Context Info
Confidence 0.78
First Reported 2006
Last Reported 2010
Negated 1
Speculated 3
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 11.60
Pain Relevance 2.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cast) cell cycle (Cast) cytoplasm (Cast)
Anatomy Link Frequency
neurons 4
livers 3
neuronal 2
hepatocytes 2
brain 2
Cast (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 4 100.00 Very High Very High Very High
Inflammation 1 100.00 Very High Very High Very High
long-term potentiation 28 99.44 Very High Very High Very High
Hippocampus 136 98.56 Very High Very High Very High
Paracetamol 22 96.84 Very High Very High Very High
Sciatic nerve 2 88.72 High High
withdrawal 4 86.32 High High
cerebral cortex 48 78.84 Quite High
Abeta 16 75.00 Quite High
Neuropathic pain 2 75.00 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 1 100.00 Very High Very High Very High
Frailty 96 99.96 Very High Very High Very High
Hepatotoxicity 17 99.96 Very High Very High Very High
Disease 160 99.56 Very High Very High Very High
Urological Neuroanatomy 48 98.68 Very High Very High Very High
Nervous System Injury 9 98.56 Very High Very High Very High
Sprains And Strains 4 98.54 Very High Very High Very High
Hypertension 2 98.40 Very High Very High Very High
Injury 76 97.12 Very High Very High Very High
Overdose 5 96.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, CAST overexpression could be used as a therapeutic strategy to prevent progression of liver injury where liver regeneration is severely hampered.
Gene_expression (overexpression) of CAST in liver associated with injury
1) Confidence 0.78 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.68 Pain Relevance 0.36
By examining expression of calpastatin (CAST), an endogenous inhibitor of calpain in three liver cell division models known to be resistant to hepatotoxicity, we tested the hypothesis that increased CAST in the dividing hepatocytes affords resistance against progression of injury.
Gene_expression (expression) of calpastatin in hepatocytes associated with injury and hepatotoxicity
2) Confidence 0.78 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.83 Pain Relevance 0
By examining expression of calpastatin (CAST), an endogenous inhibitor of calpain in three liver cell division models known to be resistant to hepatotoxicity, we tested the hypothesis that increased CAST in the dividing hepatocytes affords resistance against progression of injury.
Gene_expression (expression) of CAST in hepatocytes associated with injury and hepatotoxicity
3) Confidence 0.78 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.83 Pain Relevance 0
Immunohistochemistry revealed overexpression of calpastatin in the newly dividing/divided cells, explaining inhibition of hydrolytic enzyme calpain in perinecrotic areas and lower progression of APAP-initiated injury in the DB mice.
Gene_expression (overexpression) of calpastatin associated with diabetes mellitus and injury
4) Confidence 0.76 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16207833 Disease Relevance 1.67 Pain Relevance 0.13
To test whether CAST overexpression confers resistance against hepatotoxicity, CAST was overexpressed in the livers of normal SW mice using adenovirus before challenging them with acetaminophen (APAP) overdose.
Spec (whether) Gene_expression (overexpression) of CAST in livers associated with paracetamol, hepatotoxicity and overdose
5) Confidence 0.68 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.94 Pain Relevance 0.34
To test whether CAST overexpression confers resistance against hepatotoxicity, CAST was overexpressed in the livers of normal SW mice using adenovirus before challenging them with acetaminophen (APAP) overdose.
Gene_expression (overexpressed) of CAST in livers associated with paracetamol, hepatotoxicity and overdose
6) Confidence 0.68 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.92 Pain Relevance 0.36
A previous study indicated an increased degree of synaptic potentiation in the Milan hypertensive strain of rat, which is known to have genetic deficiencies including decreased calpastatin expression [13].
Gene_expression (expression) of calpastatin associated with hypertension and sprains and strains
7) Confidence 0.65 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 1.26 Pain Relevance 0.17
The total distance traveled was not significantly affected by the lack of calpastatin (F1,36 = 0.383, P = 0.540 in the first 60 min; F1,36 = 1.56, P = 0.220 in the following 60 min) (Figure 2Ab).
Neg (lack) Gene_expression (lack) of calpastatin
8) Confidence 0.56 Published 2008 Journal Mol Brain Section Body Doc Link PMC2561015 Disease Relevance 0.35 Pain Relevance 0.16
(25–35)-injected mice receiving vehicle, and administration of Kihi-to tended to increase the calpastatin expression levels in those regions (Figure 8B).
Gene_expression (expression) of calpastatin
9) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.09 Pain Relevance 0
Therefore we investigated the expression levels of calpain and calpastatin in cortical neurons.
Spec (investigated) Gene_expression (expression) of calpastatin in neurons
10) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.20 Pain Relevance 0
Immunocytochemistry for measures of neurite length and expressions of calpain and calpastatin
Gene_expression (expressions) of calpastatin in neurite
11) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
Expression levels of calpain and calpastatin in MAP2-positive neuronal cell bodies were quantified using ATTO densitography as described in a Immunohistochemistry method.


Gene_expression (levels) of calpastatin in neuronal
12) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
Expression levels of calpain and calpastatin in MAP2-positive neuronal cell bodies were quantified using ATTO densitography as described in a Immunohistochemistry method.


Gene_expression (Expression) of calpastatin in neuronal
13) Confidence 0.48 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0 Pain Relevance 0
Therefore, immunocytochemistry is more suitable than Western blotting for quantification of the neuron-specific expressions of calpain and calpastatin.
Gene_expression (expressions) of calpastatin in neuron
14) Confidence 0.42 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.16 Pain Relevance 0
On the other hand, expression levels of calpastatin tended to be decreased in the cortex and CA3 of A?
Gene_expression (expression) of calpastatin in cortex
15) Confidence 0.42 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.10 Pain Relevance 0
There are not significant differences of calpain and calpastatin expressions between control and A?
Gene_expression (expressions) of calpastatin
16) Confidence 0.42 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.09 Pain Relevance 0
By contrast, the expression level of calpastatin, an endogenous inhibitor of calpain, in the cytosol of MAP2-positive neurons continuously decreased at 2 h to 96 h after the treatment of A?
Gene_expression (expression) of calpastatin in neurons
17) Confidence 0.42 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.13 Pain Relevance 0
Further, previous studies have demonstrated an inverse correlation between calpain and calpastatin expression levels in the brain of Tg2576, a mouse model of Alzheimer's disease [42].
Gene_expression (levels) of calpastatin in brain associated with disease
18) Confidence 0.37 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.33 Pain Relevance 0
Therefore we investigated the expression levels of calpain and calpastatin in cortical neurons.
Spec (investigated) Gene_expression (levels) of calpastatin in neurons
19) Confidence 0.37 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.19 Pain Relevance 0
Further, previous studies have demonstrated an inverse correlation between calpain and calpastatin expression levels in the brain of Tg2576, a mouse model of Alzheimer's disease [42].
Gene_expression (expression) of calpastatin in brain associated with disease
20) Confidence 0.37 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.33 Pain Relevance 0

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