INT130755

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Context Info
Confidence 0.70
First Reported 2006
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 4.30
Pain Relevance 1.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Cast) cell cycle (Cast) cytoplasm (Cast)
Anatomy Link Frequency
livers 6
Cast (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 14 96.84 Very High Very High Very High
Abeta 1 50.00 Quite Low
Neuritis 1 7.44 Low Low
Hippocampus 8 5.00 Very Low Very Low Very Low
Eae 4 5.00 Very Low Very Low Very Low
cerebral cortex 3 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
Intracerebroventricular 1 5.00 Very Low Very Low Very Low
Thalamus 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 11 99.96 Very High Very High Very High
Injury 30 97.08 Very High Very High Very High
Overdose 3 96.00 Very High Very High Very High
Diabetes Mellitus 17 95.56 Very High Very High Very High
Urological Neuroanatomy 3 92.12 High High
Acute Liver Failure 3 57.72 Quite High
Cognitive Disorder 13 50.00 Quite Low
Neuritis 1 7.44 Low Low
Death 15 5.00 Very Low Very Low Very Low
Disease 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In conclusion, CAST overexpression could be used as a therapeutic strategy to prevent progression of liver injury where liver regeneration is severely hampered.
Positive_regulation (overexpression) of Gene_expression (overexpression) of CAST in liver associated with injury
1) Confidence 0.70 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.68 Pain Relevance 0.36
Immunohistochemistry revealed overexpression of calpastatin in the newly dividing/divided cells, explaining inhibition of hydrolytic enzyme calpain in perinecrotic areas and lower progression of APAP-initiated injury in the DB mice.
Positive_regulation (overexpression) of Gene_expression (overexpression) of calpastatin associated with diabetes mellitus and injury
2) Confidence 0.68 Published 2006 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 16207833 Disease Relevance 1.67 Pain Relevance 0.13
To test whether CAST overexpression confers resistance against hepatotoxicity, CAST was overexpressed in the livers of normal SW mice using adenovirus before challenging them with acetaminophen (APAP) overdose.
Spec (whether) Positive_regulation (overexpression) of Spec (whether) Gene_expression (overexpression) of CAST in livers associated with paracetamol, hepatotoxicity and overdose
3) Confidence 0.61 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.94 Pain Relevance 0.34
To test whether CAST overexpression confers resistance against hepatotoxicity, CAST was overexpressed in the livers of normal SW mice using adenovirus before challenging them with acetaminophen (APAP) overdose.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of CAST in livers associated with paracetamol, hepatotoxicity and overdose
4) Confidence 0.61 Published 2006 Journal Hepatology Section Abstract Doc Link 16871587 Disease Relevance 0.92 Pain Relevance 0.36
(25–35)-injected mice receiving vehicle, and administration of Kihi-to tended to increase the calpastatin expression levels in those regions (Figure 8B).
Positive_regulation (increase) of Gene_expression (expression) of calpastatin
5) Confidence 0.43 Published 2008 Journal BMC Complement Altern Med Section Body Doc Link PMC2532680 Disease Relevance 0.09 Pain Relevance 0

General Comments

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