INT130773

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Context Info
Confidence 0.37
First Reported 2005
Last Reported 2010
Negated 3
Speculated 2
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.87
Pain Relevance 1.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (FAS) protein complex assembly (FAS) cytoplasm (FAS)
signal transducer activity (FAS) cytosol (FAS) signal transduction (FAS)
Anatomy Link Frequency
endothelial cells 4
plasma 2
T lymphocytes 2
FAS (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 83 99.44 Very High Very High Very High
Inflammatory response 9 99.04 Very High Very High Very High
Morphine 9 98.98 Very High Very High Very High
ischemia 3 66.48 Quite High
Inflammation 58 65.24 Quite High
chemokine 10 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Inflammatory mediators 6 5.00 Very Low Very Low Very Low
Nerve growth factor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 30 99.80 Very High Very High Very High
Apoptosis 132 99.60 Very High Very High Very High
INFLAMMATION 73 99.04 Very High Very High Very High
Hypothermia 13 96.64 Very High Very High Very High
Burns 74 96.40 Very High Very High Very High
Acute Renal Failure 83 95.88 Very High Very High Very High
Fever 8 92.48 High High
Chorioamnionitis 198 90.00 High High
Dengue 25 86.32 High High
Coronary Heart Disease 4 83.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fas expression did not change in the presence of healthy plasma (Figure 4C), whereas it was markedly up-regulated with burns septic ARF group plasma (Figure 4D).
Neg (not) Regulation (change) of Gene_expression (expression) of Fas in plasma associated with acute renal failure and burns
1) Confidence 0.37 Published 2008 Journal Crit Care Section Body Doc Link PMC2447585 Disease Relevance 1.66 Pain Relevance 0
A higher Fas expression was observed after reperfusion in ModHT patients, but not in those operated under mild hypothermia, which tended to show less Fas positive cells after weaning from CPB.
Neg (not) Regulation (was) of Gene_expression (expression) of Fas associated with hypothermia
2) Confidence 0.30 Published 2007 Journal J Cardiothorac Surg Section Body Doc Link PMC1783850 Disease Relevance 0.76 Pain Relevance 0.03
Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.
Spec (whether) Regulation (regulation) of Gene_expression (expression) of Fas associated with death, cytokine and morphine
3) Confidence 0.29 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.70 Pain Relevance 0.87
Fas protein is expressed on the surface of many cell types, such as lymphocytes, epithelial, fibroblasts and certain endothelial cells, and cytokines [7] and hormones [35] found in the placental microenvironment may modulate the immune response by regulating the expression of Fas and Fas ligand.
Regulation (regulating) of Gene_expression (expression) of Fas in endothelial cells associated with cytokine
4) Confidence 0.22 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.85 Pain Relevance 0.05
The functional significance of these polymorphisms has not been fully elucidated but they may modulate TNFRSF6 transcription, Fas expression and thus apoptotic and inflammatory responses.
Spec (may) Regulation (modulate) of Gene_expression (expression) of Fas associated with inflammatory response and apoptosis
5) Confidence 0.22 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 1.26 Pain Relevance 0.15
In contrast, no differences in CD95 expression on CD3+ CD8+ T lymphocytes were observed.
Neg (no) Regulation (differences) of Gene_expression (expression) of CD95 in T lymphocytes
6) Confidence 0.19 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3013083 Disease Relevance 0.80 Pain Relevance 0.18
Fas protein is expressed on the surface of many cell types, such as lymphocytes, epithelial, fibroblasts and certain endothelial cells, and cytokines [7] and hormones [35] found in the placental microenvironment may modulate the immune response by regulating the expression of Fas and Fas ligand.
Regulation (regulating) of Gene_expression (expression) of Fas in endothelial cells associated with cytokine
7) Confidence 0.16 Published 2005 Journal BMC Pregnancy Childbirth Section Body Doc Link PMC554771 Disease Relevance 0.85 Pain Relevance 0.05

General Comments

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