INT130774

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Context Info
Confidence 0.67
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.02
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
T cells 2
thyroid 1
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
metalloproteinase 5 100.00 Very High Very High Very High
Morphine 9 99.62 Very High Very High Very High
Arthritis 106 92.48 High High
cytokine 36 89.48 High High
Inflammation 46 84.08 Quite High
agonist 1 27.56 Quite Low
rheumatoid arthritis 8 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Inflammatory response 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 99.00 Very High Very High Very High
Death 14 98.52 Very High Very High Very High
Apoptosis 22 97.20 Very High Very High Very High
Rheumatoid Arthritis 110 92.48 High High
INFLAMMATION 48 84.08 Quite High
Targeted Disruption 22 65.20 Quite High
Coronary Artery Disease 1 64.60 Quite High
Atherosclerosis 2 63.52 Quite High
Asthma 1 59.68 Quite High
Autoimmune Disease 21 59.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although CIITA was initially described as a master regulator of MHC class II transcription, it is now clear that it can both activate and suppress transcription of several genes such as collagen (6), matrix metalloproteinase-9 (7), IL-4 (8), Fas ligand (9) and thyroid specific genes (10, 11).
Transcription (transcription) of Fas ligand in thyroid associated with metalloproteinase
1) Confidence 0.67 Published 2006 Journal Journal of Korean Medical Science Section Body Doc Link PMC2721999 Disease Relevance 0.12 Pain Relevance 0.08
Furthermore, morphine enhanced the mRNA expression of Fas, FasL and TRAIL and promoted Fas-mediated AICD of CD4(+) T cells.
Transcription (expression) of FasL in T cells associated with death and morphine
2) Confidence 0.31 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.67 Pain Relevance 0.87
Interestingly, Krammer and Colleagues demonstrated that in vitro administration of vitamin E suppresses FasL mRNA expression and protects T cells of HIV-1 infected individuals from Fas mediated apoptosis [28].
Transcription (expression) of FasL in T cells associated with acquired immune deficiency syndrome or hiv infection and apoptosis
3) Confidence 0.26 Published 2008 Journal Nutr J Section Body Doc Link PMC2572622 Disease Relevance 0.75 Pain Relevance 0.06
Unphosphorylated active FOXO family proteins promote transcription of genes that regulate cell-cycle progression and survival, including CDKN1B [84], FASLG and BCL2L11 [85], which also have been listed in the map.
Transcription (transcription) of FASLG
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.47 Pain Relevance 0.21
As judged by RT–PCR, changes in cytotoxicity correlated with changes in FasL mRNA expression (Figure 7B, lower panel).
Transcription (expression) of FasL
5) Confidence 0.16 Published 2007 Journal EMBO J Section Body Doc Link PMC1914094 Disease Relevance 0 Pain Relevance 0

General Comments

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