INT130775

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Context Info
Confidence 0.30
First Reported 2005
Last Reported 2010
Negated 0
Speculated 2
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 5.80
Pain Relevance 1.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (FASLG) extracellular space (FASLG) extracellular region (FASLG)
plasma membrane (FASLG) cell-cell signaling (FASLG)
Anatomy Link Frequency
T cells 1
FASLG (Homo sapiens)
Pain Link Frequency Relevance Heat
cytokine 202 99.44 Very High Very High Very High
Morphine 9 98.98 Very High Very High Very High
Inflammation 193 95.48 Very High Very High Very High
Arthritis 108 92.48 High High
rheumatoid arthritis 9 86.92 High High
metalloproteinase 5 53.72 Quite High
Crohn's disease 1 49.12 Quite Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
dexamethasone 7 5.00 Very Low Very Low Very Low
methotrexate 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 64 99.36 Very High Very High Very High
Apoptosis 93 98.72 Very High Very High Very High
Syndrome 14 97.90 Very High Very High Very High
Diabetes Mellitus 5 97.24 Very High Very High Very High
Autoimmune Lymphoproliferative Syndrome 1 96.68 Very High Very High Very High
Aging 106 95.84 Very High Very High Very High
INFLAMMATION 213 95.48 Very High Very High Very High
Stress 28 94.96 High High
Rheumatoid Arthritis 112 92.48 High High
Autoimmune Disease 31 90.60 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Unphosphorylated active FOXO family proteins promote transcription of genes that regulate cell-cycle progression and survival, including CDKN1B [84], FASLG and BCL2L11 [85], which also have been listed in the map.
Regulation (regulate) of FASLG
1) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2855702 Disease Relevance 0.47 Pain Relevance 0.21
Therefore, we analyzed whether the ability of morphine to affect Th2 cytokine production was mediated by regulation of Fas, FasL, and TRAIL expression and AICD directly in purified Th cells.
Spec (whether) Regulation (regulation) of FasL associated with death, cytokine and morphine
2) Confidence 0.27 Published 2005 Journal J. Immunol. Section Abstract Doc Link 16210602 Disease Relevance 0.69 Pain Relevance 0.86
Other cytokines, such as lymphotoxin (LT), interleukin-1 (IL-1), interleukin-6 (IL-6) and soluble Fas ligand (FasL) serve similar functions.
Regulation (soluble) of FasL associated with cytokine
3) Confidence 0.13 Published 2006 Journal Malar J Section Body Doc Link PMC1629020 Disease Relevance 0.90 Pain Relevance 0.49
Affymetrix microarray analysis of gene expression profiles revealed that butyrate treatment down-regulated pro-apoptotic BAD, BAX and BAK, genes associated with the mitochondrial pathway, while genes associated with the death receptor pathway, such as Fas, FasL, Trail and DR5, were basically not affected by the treatment (data not shown).
Regulation (affected) of FasL associated with apoptosis and death
4) Confidence 0.11 Published 2006 Journal Mol Cancer Section Body Doc Link PMC1762018 Disease Relevance 0.92 Pain Relevance 0
In fact, autoimmune lymphoproliferative syndrome (ALPS), MS, type 1 diabetes and multiple autoimmune syndrome, have been linked to decreased Fas functionality [68] and, as discussed previously, antioxidants may up-regulate Fas and FasL in vitro.
Spec (may) Regulation (regulate) of FasL associated with syndrome, diabetes mellitus and autoimmune lymphoproliferative syndrome
5) Confidence 0.10 Published 2008 Journal Nutr J Section Body Doc Link PMC2572622 Disease Relevance 1.80 Pain Relevance 0.26
This decreased apoptosis in CD8+ T cells is primarily associated with defects in the up-regulation of FasL after activation and a decrease in Fas apoptosis signaling (Hsu et al 2001).
Regulation (regulation) of FasL in T cells associated with apoptosis
6) Confidence 0.09 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 1.02 Pain Relevance 0

General Comments

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