INT130785

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Context Info
Confidence 0.62
First Reported 2005
Last Reported 2010
Negated 2
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.56
Pain Relevance 2.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Arc) plasma membrane (Arc) cytoskeleton (Arc)
cytoskeleton organization (Arc) cytoplasm (Arc)
Anatomy Link Frequency
neurons 1
brain 1
internal 1
Arc (Mus musculus)
Pain Link Frequency Relevance Heat
ASIC 15 99.18 Very High Very High Very High
Hippocampus 14 99.06 Very High Very High Very High
Morphine 8 98.68 Very High Very High Very High
Opioid 2 98.24 Very High Very High Very High
antagonist 1 97.96 Very High Very High Very High
tolerance 1 97.16 Very High Very High Very High
withdrawal 3 96.64 Very High Very High Very High
opiate 1 96.32 Very High Very High Very High
long-term potentiation 24 96.16 Very High Very High Very High
Nucleus accumbens 2 95.04 Very High Very High Very High
Disease Link Frequency Relevance Heat
Aids-related Complex 704 100.00 Very High Very High Very High
Weight Loss 2 94.96 High High
Body Weight 5 94.76 High High
Targeted Disruption 36 94.64 High High
Nociception 41 91.16 High High
Depression 7 84.16 Quite High
Neuroblastoma 1 75.00 Quite High
Weight Gain 2 70.80 Quite High
Pain 40 62.96 Quite High
INFLAMMATION 24 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
No changes in the striatal Arc mRNA levels were observed during spontaneous or opioid antagonist-precipitated morphine withdrawal.
Neg (No) Regulation (changes) of Arc mRNA associated with aids-related complex, antagonist, withdrawal, opioid and morphine
1) Confidence 0.62 Published 2005 Journal J. Neurosci. Res. Section Abstract Doc Link 16211563 Disease Relevance 0.90 Pain Relevance 1.25
associated protein/activity-regulated gene 3.1 (Arc/Arg3.1), and Zif268 (also
Regulation (regulated) of Arg3.1 associated with aids-related complex
2) Confidence 0.44 Published 2008 Journal Neural Plasticity Section Body Doc Link PMC2631155 Disease Relevance 0.49 Pain Relevance 0.19
Using PMT luminometry, a significant difference in the phase of peak PER2::LUC bioluminescence in the Arc complex was observed in food deprived versus time matched control animals (35. 8 ± 2.1 h vs. 31.3 ± 0.8 h respectively; p < 0.05, Table 2).
Regulation (difference) of Arc associated with aids-related complex
3) Confidence 0.35 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.41 Pain Relevance 0
Recently it has become clear that in cortex, hippocampus and other higher brain centers, the IEG named Arc/Arg3.1 (activity regulated cytoskeleton-associated protein/activity regulated gene 3.1) plays a crucial role in activity dependent synaptic plasticity [12].
Regulation (regulated) of Arc/Arg3.1 in brain associated with aids-related complex and hippocampus
4) Confidence 0.21 Published 2010 Journal Mol Pain Section Body Doc Link PMC2920254 Disease Relevance 1.05 Pain Relevance 0.52
This study defines multiple circadian oscillators with different properties, in brain regions crucial for internal homeostatic regulation including the Arc, ME/PT and ependymal cell layer of the 3rd ventricle and reveals, for the first time, endogenous rhythms in the DMH.
Regulation (regulation) of Arc in internal associated with aids-related complex
5) Confidence 0.21 Published 2009 Journal Mol Brain Section Body Doc Link PMC2745382 Disease Relevance 0.41 Pain Relevance 0
There were no significant changes in ARC Kiss1 mRNA levels across maturation in either WT females or males (P>0.05; ANOVA).
Neg (no) Regulation (changes) of ARC associated with aids-related complex
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.73 Pain Relevance 0
In the ARC, kisspeptin immunoreactivity was digitally imaged.
Regulation (immunoreactivity) of ARC associated with aids-related complex
7) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.23 Pain Relevance 0
Utilizing ISH and qRT-PCR confirmed that hpg mice had robustly elevated Kiss1 expression in striking contrast to kisspeptin immunostaining, which could easily be misinterpreted as reduced kisspeptin immunoreactivity in the hpg ARC.
Regulation (immunoreactivity) of ARC associated with aids-related complex
8) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.75 Pain Relevance 0.05
The functional response of kisspeptin neurons in the ARC to exogenous E2 was also examined by monitoring the changes of kisspeptin immunostaining patterns surrounding the median eminence.
Spec (examined) Regulation (response) of ARC in neurons associated with aids-related complex
9) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912854 Disease Relevance 0.34 Pain Relevance 0
To address ASIC subunit specificity, we recorded AGM or ARC responses in CHO cells expressing different combinations of ASIC subunits (Figure 7).
Regulation (responses) of ARC associated with aids-related complex and asic
10) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3017031 Disease Relevance 0.26 Pain Relevance 0.19

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