INT130797

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Context Info
Confidence 0.66
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 4.73
Pain Relevance 0.77

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23)
Anatomy Link Frequency
fibroblast 1
Fgf23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 11 93.12 High High
Fibrositis 2 85.68 High High
Neuropeptide 1 60.68 Quite High
rheumatoid arthritis 1 43.60 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2 99.28 Very High Very High Very High
Rickets 8 99.24 Very High Very High Very High
Familial Hypophosphatemia 22 99.16 Very High Very High Very High
Osteoporosis 45 96.96 Very High Very High Very High
Pain 8 93.12 High High
Alkalosis 2 86.36 High High
Sleep Disorders 2 85.68 High High
Acidosis 2 80.00 Quite High
Bone Cancer 2 76.64 Quite High
Low Back Pain 2 67.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that 1,25(OH)2D3 upregulates FGF23 gene expression in bone [34] and undetectable serum levels of FGF23 are found in mice lacking the vitamin D receptor [35], downregulation of FGF23 in the OVX-D group could be explained by lack of dietary vitamin D.
Gene_expression (expression) of FGF23
1) Confidence 0.66 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.28 Pain Relevance 0.03
Serum phosphate was significantly lower in patients than in controls, but FGF23 levels did not differ.
Gene_expression (levels) of FGF23
2) Confidence 0.57 Published 2009 Journal Calcif. Tissue Int. Section Abstract Doc Link 19148564 Disease Relevance 1.34 Pain Relevance 0.19
Normal FGF23 levels in adult idiopathic phosphate diabetes.
Gene_expression (levels) of FGF23 associated with familial hypophosphatemia
3) Confidence 0.51 Published 2009 Journal Calcif. Tissue Int. Section Title Doc Link 19148564 Disease Relevance 1.17 Pain Relevance 0.18
Importantly, the phosphaturic factor FGF23 was differentially processed, as reflected by low intact (15 pg/ml) but high C-terminal (839 RU/ml) serum FGF23 levels.
Gene_expression (levels) of FGF23
4) Confidence 0.45 Published 2008 Journal Eur. J. Endocrinol. Section Body Doc Link 18322299 Disease Relevance 0.06 Pain Relevance 0
The FGF23 has also been implicated in autosomal dominant hypophosphatemic rickets, in which a gene mutation results in production of abnormal FGF23 that resists hydrolysis.
Gene_expression (production) of FGF23 associated with rickets
5) Confidence 0.34 Published 2005 Journal Joint Bone Spine Section Abstract Doc Link 16214071 Disease Relevance 0.84 Pain Relevance 0.17
The most extensively studied phosphatonin to date is fibroblast growth factor 23 (FGF23), which was first identified in patients with tumor-induced osteomalacia and shown to be secreted by the neoplastic cells.
Gene_expression (identified) of FGF23 in fibroblast associated with rickets and cancer
6) Confidence 0.29 Published 2005 Journal Joint Bone Spine Section Abstract Doc Link 16214071 Disease Relevance 1.03 Pain Relevance 0.20

General Comments

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