INT130798

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Context Info
Confidence 0.59
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.12
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Fgf23) extracellular space (Fgf23)
Fgf23 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropeptide 1 61.16 Quite High
Pain 3 58.08 Quite High
rheumatoid arthritis 1 43.60 Quite Low
anesthesia 1 5.00 Very Low Very Low Very Low
imagery 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rickets 4 99.46 Very High Very High Very High
Cancer 1 92.80 High High
Osteoporosis 34 86.04 High High
Alkalosis 1 76.88 Quite High
Familial Hypophosphatemia 2 75.00 Quite High
Acidosis 1 70.52 Quite High
Fracture Healing 13 64.00 Quite High
Pain 2 58.08 Quite High
Low Back Pain 1 57.68 Quite High
Hypophosphatemia 1 47.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The fact that 1,25(OH)2D3 upregulates FGF23 gene expression in bone [34] and undetectable serum levels of FGF23 are found in mice lacking the vitamin D receptor [35], downregulation of FGF23 in the OVX-D group could be explained by lack of dietary vitamin D.
Positive_regulation (upregulates) of Gene_expression (expression) of FGF23
1) Confidence 0.59 Published 2010 Journal Calcif Tissue Int Section Body Doc Link PMC2887935 Disease Relevance 0.28 Pain Relevance 0.03
The FGF23 has also been implicated in autosomal dominant hypophosphatemic rickets, in which a gene mutation results in production of abnormal FGF23 that resists hydrolysis.
Positive_regulation (results) of Gene_expression (production) of FGF23 associated with rickets
2) Confidence 0.30 Published 2005 Journal Joint Bone Spine Section Abstract Doc Link 16214071 Disease Relevance 0.85 Pain Relevance 0.17

General Comments

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