INT1308

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Context Info
Confidence 0.81
First Reported 1977
Last Reported 2010
Negated 3
Speculated 9
Reported most in Abstract
Documents 457
Total Number 466
Disease Relevance 66.83
Pain Relevance 217.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pomc) generation of precursor metabolites and energy (Pomc) extracellular space (Pomc)
extracellular region (Pomc) molecular_function (Pomc) cell-cell signaling (Pomc)
Anatomy Link Frequency
pituitary 42
hypothalamus 32
brain 28
plasma 16
neurons 13
Pomc (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 436 100.00 Very High Very High Very High
Opioid 413 100.00 Very High Very High Very High
narcan 391 100.00 Very High Very High Very High
Enkephalin 390 100.00 Very High Very High Very High
opiate 197 100.00 Very High Very High Very High
Morphine 193 100.00 Very High Very High Very High
Dynorphin 160 100.00 Very High Very High Very High
Dopamine 159 100.00 Very High Very High Very High
Pain 151 100.00 Very High Very High Very High
Serotonin 143 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Stress 432 100.00 Very High Very High Very High
Amnesia 13 100.00 Very High Very High Very High
Hypothermia 4 100.00 Very High Very High Very High
Hypopituitarism 2 100.00 Very High Very High Very High
Shock 27 99.96 Very High Very High Very High
Cancer 86 99.92 Very High Very High Very High
Urological Neuroanatomy 72 99.84 Very High Very High Very High
Sepsis 63 99.84 Very High Very High Very High
Cv Unclassified Under Development 4 99.84 Very High Very High Very High
INFLAMMATION 210 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
It was noticed that there was very little beta-endorphin in the radiolabelled biosynthesized products, suggesting that either the maturation processing of proopiomelanocortin was modified, or that beta-endorphin was released immediately as soon as it was formed and did not accumulate in the tissue.
Localization (released) of beta-endorphin
1) Confidence 0.81 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2942231 Disease Relevance 0 Pain Relevance 0.24
Furthermore, the NIL transplant seemed to produce a substance or substances which could decrease the content, the biosynthesis and the release of beta-endorphin-like peptides by the NIL in situ.
Localization (release) of beta-endorphin-like in NIL
2) Confidence 0.81 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2942231 Disease Relevance 0 Pain Relevance 0.38
The NIL transplant contained, synthesized, and released beta-endorphin-like peptides.
Localization (released) of beta-endorphin-like in NIL
3) Confidence 0.81 Published 1986 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2942231 Disease Relevance 0 Pain Relevance 0.16
The in vitro release of beta-endorphin-related peptides from the anterior pituitary was increased; the tissue concentrations, however, remained unchanged.
Localization (release) of beta-endorphin in anterior pituitary
4) Confidence 0.81 Published 1984 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 6086890 Disease Relevance 0 Pain Relevance 0.06
Chronic treatment of rats with 15% (vol/vol) ethanol in tap water as their only source of liquid over a period of 3 weeks resulted in a strong decrease by almost 50% in tissue levels and in vitro release of immunoreactive beta-endorphin of the neurointermediate pituitary.
Localization (release) of beta-endorphin in pituitary
5) Confidence 0.81 Published 1984 Journal J. Neurochem. Section Abstract Doc Link 6086835 Disease Relevance 0 Pain Relevance 0
Beta-endorphin(beta EP)1-31, a potent opioid peptide of proopiomelanocortin (POMC) derivatives, is produced and released from neurons at arcuate nuclei of the rat hypothalamus.
Localization (released) of Beta-endorphin in hypothalamus associated with opioid
6) Confidence 0.80 Published 1994 Journal Brain Res. Section Abstract Doc Link 7522925 Disease Relevance 0 Pain Relevance 0.19
Acute stress promotes the secretion of prolactin (PRL) and of proopiomelanocortin (POMC)-derived peptides, adrenocorticotropic hormone and beta-endorphin, from the pituitary into the systemic circulation.
Localization (secretion) of beta-endorphin in pituitary associated with stress
7) Confidence 0.80 Published 1986 Journal Neuroendocrinology Section Abstract Doc Link 2942792 Disease Relevance 0.35 Pain Relevance 0
Furthermore, the results are also consistent with previous observations that beta-endorphin is released from the rat brain during training, but not during test sessions of the two tasks (Izquierdo et al., 1980b).
Localization (released) of beta-endorphin in brain
8) Confidence 0.80 Published 1980 Journal Psychopharmacology (Berl.) Section Abstract Doc Link 6248917 Disease Relevance 0 Pain Relevance 0.33
Immunohistochemical localization of beta-endorphin containing structures in the vicinity of stimulating and recording sites suggested that the naloxone sensitive inhibition of nociceptive neuronal responses in caudal medulla reticular formation may be due to activation of beta-endorphin fibres descending through the periaqueductal area to the caudal medulla.
Localization (localization) of beta-endorphin in reticular formation associated with nociception, medulla and narcan
9) Confidence 0.80 Published 1983 Journal Pain Section Abstract Doc Link 6304597 Disease Relevance 0.47 Pain Relevance 0.86
These findings indicate that dopaminergic neurons in the arcuate nucleus may induce the secretion of beta-endorphin in the nucleus accumbens, and that they are implicated in the cocaine reward pathway.
Localization (secretion) of beta-endorphin in nucleus accumbens associated with nucleus accumbens and cocaine
10) Confidence 0.80 Published 2006 Journal Neuroreport Section Abstract Doc Link 17001283 Disease Relevance 0 Pain Relevance 0.59
Our previous studies indicate that endogenous opioids (primarily beta-endorphin) released during stressful stimuli can interact with peripheral opioid receptors to inhibit nociception in inflamed tissue of rats.
Localization (released) of beta-endorphin associated with nociception, endogenous opioid and opioid receptor
11) Confidence 0.80 Published 1992 Journal Neuroscience Section Abstract Doc Link 1603330 Disease Relevance 0.24 Pain Relevance 0.59
While enkephalin and dynorphin peptides have been well characterized in the spinal cord, the cellular localization of beta-endorphin (beta E) and the processing of pro-opiomelanocortin (POMC) to beta E and other non-opioid peptides in the cord have not been extensively investigated.
Localization (localization) of beta-endorphin in spinal cord associated with dynorphin, enkephalin, opioid and spinal cord
12) Confidence 0.80 Published 1992 Journal Pain Section Abstract Doc Link 1336592 Disease Relevance 0 Pain Relevance 0.43
Effect of anaesthetics on the release of beta-endorphin-immunoreactivity in rat plasma.
Localization (release) of beta-endorphin in plasma associated with analgesic
13) Confidence 0.80 Published 1991 Journal Life Sci. Section Title Doc Link 2008154 Disease Relevance 0 Pain Relevance 0.52
OBJECTIVES: The goal of this current study was to investigate the hypotheses that the AA and ANA rats will show differences in the release of beta-endorphin at the level of nucleus accumbens (NAC) and in locomotor activity in response to acute systemic administration of ethanol.
Localization (release) of beta-endorphin in NAC
14) Confidence 0.80 Published 2010 Journal Psychopharmacology (Berl.) Section Body Doc Link 19940981 Disease Relevance 0 Pain Relevance 0
This direct evidence for the release of endogenous beta-endorphin in the brain in response to nociceptive stimulus indicates a possible mechanism for organisms to cope with pain.
Localization (release) of beta-endorphin in brain associated with nociception and pain
15) Confidence 0.80 Published 1998 Journal Neuroscience Section Abstract Doc Link 9639262 Disease Relevance 0.54 Pain Relevance 0.25
Effects of acute ethanol on beta-endorphin release in the nucleus accumbens of selectively bred lines of alcohol-preferring AA and alcohol-avoiding ANA rats.
Localization (release) of beta-endorphin in nucleus accumbens associated with nucleus accumbens and alcohol
16) Confidence 0.80 Published 2010 Journal Psychopharmacology (Berl.) Section Title Doc Link 19940981 Disease Relevance 0 Pain Relevance 0.54
Thus these experiments found no evidence for beta-endorphin release following a severe peripheral painful stimulus.
Localization (release) of beta-endorphin associated with pain
17) Confidence 0.80 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8474693 Disease Relevance 0.07 Pain Relevance 0.25
Noxious mechanical stimulation of the hind paws of the anaesthetized rat fails to elicit release of immunoreactive beta-endorphin in the periaqueductal grey matter.
Localization (release) of beta-endorphin in grey matter associated with anesthesia and periaqueductal grey
18) Confidence 0.80 Published 1993 Journal Neurosci. Lett. Section Title Doc Link 8474693 Disease Relevance 0.10 Pain Relevance 0.36
As a test of the hypothesis that an animal responds to a severe peripheral painful stimulus by a central release of beta-endorphin, antibody microprobes were inserted stereotactically into the midbrain of urethane anesthetized rats.
Localization (release) of beta-endorphin in midbrain associated with pain and midbrain
19) Confidence 0.80 Published 1993 Journal Neurosci. Lett. Section Abstract Doc Link 8474693 Disease Relevance 0.07 Pain Relevance 0.19
It is proposed that beta-endorphin AS has a two-stage selective effect: a reduction in beta-endorphin release followed by a 'rebound' increase.
Localization (release) of beta-endorphin
20) Confidence 0.80 Published 1990 Journal Biomed. Sci. Section Abstract Doc Link 2133063 Disease Relevance 0.41 Pain Relevance 0.27

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