INT130814

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Context Info
Confidence 0.48
First Reported 2006
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 8
Total Number 9
Disease Relevance 4.83
Pain Relevance 1.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (ANPEP) cytosol (ANPEP) peptidase activity (ANPEP)
plasma membrane (ANPEP) cytoplasm (ANPEP)
Anatomy Link Frequency
plasma 2
endothelial cells 2
blood vessels 1
ANPEP (Homo sapiens)
Pain Link Frequency Relevance Heat
diclofenac 56 99.80 Very High Very High Very High
Inflammation 36 97.72 Very High Very High Very High
tolerance 22 89.04 High High
chemokine 3 87.12 High High
Pain management 2 85.36 High High
cINOD 4 66.32 Quite High
imagery 11 5.76 Low Low
Enkephalin 4 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 74 99.88 Very High Very High Very High
Necrosis 6 98.34 Very High Very High Very High
Disease 81 98.08 Very High Very High Very High
INFLAMMATION 40 97.72 Very High Very High Very High
Hepatocellular Cancer 87 97.12 Very High Very High Very High
Liver Cancer 18 91.40 High High
Impaired Glucose Tolerance 22 89.04 High High
Pain 5 85.36 High High
Shock 2 77.20 Quite High
Toxicity 50 71.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APN/CD13 serves as a receptor for coronaviruses.
APN Binding (receptor) of
1) Confidence 0.48 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.61 Pain Relevance 0.20
APN/CD13 serves as a receptor for coronaviruses.
CD13 Binding (receptor) of
2) Confidence 0.47 Published 2006 Journal Med Res Rev Section Abstract Doc Link 16216010 Disease Relevance 0.61 Pain Relevance 0.20
with the tumour-homing peptide asparagine–glycine–arginine (NGR), which is able to selectively bind an aminopeptidase N (CD13) isoform overexpressed by endothelial cells of many tumours, including HCC (Arap et al, 1998; Curnis et al, 2000; Corti and Ponzoni, 2004).
CD13 Binding (bind) of in endothelial cells associated with cancer and hepatocellular cancer
3) Confidence 0.47 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2966632 Disease Relevance 0.98 Pain Relevance 0.04
with the tumour-homing peptide asparagine–glycine–arginine (NGR), which is able to selectively bind an aminopeptidase N (CD13) isoform overexpressed by endothelial cells of many tumours, including HCC (Arap et al, 1998; Curnis et al, 2000; Corti and Ponzoni, 2004).
aminopeptidase N Binding (bind) of in endothelial cells associated with cancer and hepatocellular cancer
4) Confidence 0.47 Published 2010 Journal Br J Cancer Section Body Doc Link PMC2966632 Disease Relevance 0.98 Pain Relevance 0.04
NGR-hTNF is a vascular-targeting agent consisting of human tumour necrosis factor-alpha fused to the tumour-homing peptide NGR, which is able to selectively bind an aminopeptidase N overexpressed on tumour blood vessels.


aminopeptidase N Binding (bind) of in blood vessels associated with necrosis and cancer
5) Confidence 0.35 Published 2010 Journal Br J Cancer Section Abstract Doc Link PMC2966632 Disease Relevance 0.99 Pain Relevance 0
We tested the reactivity of another aminopeptidase, aminopeptidase N (ApN) with Tau because it is a related protein with very similar kinetics and substrate specificity to PSA [16].
aminopeptidase N Binding (reactivity) of
6) Confidence 0.07 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.08 Pain Relevance 0
The inhibition of the enzyme aminopeptidase N (CD13) by diclofenac corresponds to the lower plasma concentrations of several neutral amino acids such as L-isoleucine, L-threonine, and L-leucine.
aminopeptidase N Neg (inhibition) Binding (inhibition) of in plasma associated with diclofenac
7) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2643463 Disease Relevance 0.26 Pain Relevance 0.28
The inhibition of the enzyme aminopeptidase N (CD13) by diclofenac corresponds to the lower plasma concentrations of several neutral amino acids such as L-isoleucine, L-threonine, and L-leucine.
CD13 Neg (inhibition) Binding (inhibition) of in plasma associated with diclofenac
8) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2643463 Disease Relevance 0.26 Pain Relevance 0.28
We tested the reactivity of another aminopeptidase, aminopeptidase N (ApN) with Tau because it is a related protein with very similar kinetics and substrate specificity to PSA [16].
ApN Binding (reactivity) of
9) Confidence 0.06 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2988785 Disease Relevance 0.08 Pain Relevance 0

General Comments

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