INT13083

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Context Info
Confidence 0.23
First Reported 1986
Last Reported 2004
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 1.73
Pain Relevance 4.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

molecular_function (Tal2) cellular_component (Tal2) biological_process (Tal2)
Anatomy Link Frequency
tail 6
spinal 1
serotonergic neurons 1
Tal2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tail-flick 61 100.00 Very High Very High Very High
Morphine 16 100.00 Very High Very High Very High
medulla 10 100.00 Very High Very High Very High
Pain 3 99.76 Very High Very High Very High
Dorsal horn neuron 6 98.64 Very High Very High Very High
antagonist 5 98.48 Very High Very High Very High
intrathecal 11 98.32 Very High Very High Very High
Raphe 2 97.10 Very High Very High Very High
Central grey 7 96.92 Very High Very High Very High
Rostral ventromedial medulla 8 96.70 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 20 100.00 Very High Very High Very High
Urological Neuroanatomy 7 96.92 Very High Very High Very High
Hypothermia 4 75.00 Quite High
Pressure Volume 2 Under Development 1 64.08 Quite High
Heart Rate Under Development 1 62.80 Quite High
Cv Unclassified Under Development 1 49.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Stimulation-produced modulation from the rostral, medial medulla (RMM) on the spinal nociceptive tail-flick (TF) reflex and on lumbar spinal dorsal horn neuron responses to noxious cutaneous stimuli was studied in adult rats treated as neonates with capsaicin or vehicle.
Regulation (modulation) of tail-flick in spinal associated with nociception, medulla, qutenza, tail-flick and dorsal horn neuron
1) Confidence 0.23 Published 1994 Journal Brain Res. Section Abstract Doc Link 8062079 Disease Relevance 0.24 Pain Relevance 0.66
Moreover, the effects of fenfluramine on T(TAIL) and T(CORE) depended on the uptake of fenfluramine into serotonergic neurons because these effects were markedly attenuated by pretreatment with the selective serotonin re-uptake inhibitor, fluoxetine.
Regulation (effects) of TAIL in serotonergic neurons associated with serotonin and fluoxetine
2) Confidence 0.21 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 14751464 Disease Relevance 0.20 Pain Relevance 0.18
The effect on the nociceptive tail-flick (TF) reflex of cardiopulmonary chemoreceptor and arterial baroreceptor activation, producing Bezold-Jarisch like- and baro-reflex responses, respectively, was analysed in lightly halothane-anaesthetized rats.
Spec (analysed) Regulation (effect) of tail-flick in tail associated with nociception, tail-flick and halothane
3) Confidence 0.10 Published 2002 Journal Pain Section Abstract Doc Link 12237185 Disease Relevance 0.23 Pain Relevance 0.24
Centrifugal modulation of the rat tail flick reflex evoked by graded noxious heating of the tail.
Regulation (modulation) of tail flick in tail associated with pain and tail-flick
4) Confidence 0.04 Published 1986 Journal Brain Res. Section Title Doc Link 3779419 Disease Relevance 0.09 Pain Relevance 0.56
The nociceptive tail flick (TF) reflex evoked by noxious heating was unaffected by the above drugs.
Neg (unaffected) Regulation (unaffected) of tail flick in tail associated with nociception and tail-flick
5) Confidence 0.03 Published 1991 Journal Pain Section Abstract Doc Link 1661000 Disease Relevance 0.19 Pain Relevance 0.95
The antinociceptive effect of morphine administered into the periaqueductal gray (PAG), the intrathecal space (ITH) and concurrently, into both sites (in a 1:1 dose ratio), was assessed in 1) nontolerant rats, 2) rats made tolerant to the effect of morphine on the tail-flick (TF) test and 3) rats that were tested on the TF during chronic saline administration.
Regulation (effect) of tail-flick in tail associated with tail-flick, central grey, antinociceptive, intrathecal and morphine
6) Confidence 0.01 Published 1989 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 2622981 Disease Relevance 0.35 Pain Relevance 1.11
Modulation of the spinal nociceptive tail flick (TF) reflex by electrical stimulation of subdiaphragmatic or cervical vagal afferent fibers was characterized in rats lightly anesthetized with pentobarbital.
Regulation (Modulation) of tail flick in tail associated with nociception and tail-flick
7) Confidence 0.01 Published 1988 Journal Brain Res. Section Abstract Doc Link 2836031 Disease Relevance 0.17 Pain Relevance 0.35
Electrical stimulation at a total 86 sites in the RVM in the medial raphe nuclei (n = 54) and adjacent gigantocellular areas (n = 32) produced biphasic (facilitatory and inhibitory, n = 43) or only inhibitory (n = 43) modulation of the tail-flick (TF) reflex.
Regulation (modulation) of tail-flick in tail associated with tail-flick, raphe and rostral ventromedial medulla
8) Confidence 0.01 Published 1997 Journal J. Neurophysiol. Section Abstract Doc Link 9307109 Disease Relevance 0.25 Pain Relevance 0.66

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