INT130836

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Context Info
Confidence 0.72
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 5.93
Pain Relevance 3.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
retina 1
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Neuropathic pain 30 99.20 Very High Very High Very High
Inflammation 2 96.28 Very High Very High Very High
cva 12 95.44 Very High Very High Very High
hyperexcitability 3 92.84 High High
ischemia 15 84.56 Quite High
allodynia 6 83.48 Quite High
Spinal cord 4 75.00 Quite High
anesthesia 5 37.20 Quite Low
imagery 24 32.88 Quite Low
Pain 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Injury 55 99.32 Very High Very High Very High
Neuropathic Pain 39 99.20 Very High Very High Very High
INFLAMMATION 2 96.28 Very High Very High Very High
Intracranial Hypertension 7 95.44 Very High Very High Very High
Hydrocephalus 43 91.36 High High
Frailty 16 87.60 High High
Cv Unclassified Under Development 9 84.56 Quite High
Ganglion Cysts 27 84.24 Quite High
Middle Cerebral Artery Infarction 6 80.00 Quite High
Stroke 6 73.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together with the acute decreased abundance of AQP4 in the periventricular region we found normal ADC-values in the same region.
Transcription (abundance) of AQP4
1) Confidence 0.72 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.82 Pain Relevance 0.26
For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.
Transcription (levels) of AQP4 associated with neuropathic pain
2) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.98 Pain Relevance 1.59
For example, mRNA levels of glial fibrilary acidic protein (GFAP) and Aquaporin 4 (AQP4) significantly increased in CNP rats.
Transcription (levels) of Aquaporin 4 associated with neuropathic pain
3) Confidence 0.70 Published 2005 Journal J. Neurochem. Section Abstract Doc Link 16219025 Disease Relevance 1.97 Pain Relevance 1.59
Real-time analyses of AQP4/AQP9/Kir4.1/thy-1/ACTB mRNA levels
Transcription (levels) of AQP4
4) Confidence 0.68 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0 Pain Relevance 0
The same study reported that the human Müller cell line MIO-M1 [11] expressed mRNA for AQP0, AQP1, AQP3, AQP4, AQP5, AQP7, AQP8, AQP9, AQP10, and AQP11 but not AQP2, AQP6, and AQP12 [10].
Transcription (expressed) of AQP4
5) Confidence 0.65 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.62 Pain Relevance 0
In the present study using the rat ONC model, we have shown for the first time that such injury causes a significant decrease in AQP4 and Kir4.1 protein and mRNA levels in retina, suggesting impaired ion homeostasis and K+ spatial buffering.
Transcription (levels) of AQP4 in retina associated with injury
6) Confidence 0.50 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2831780 Disease Relevance 0.54 Pain Relevance 0.09

General Comments

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