INT130837

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Context Info
Confidence 0.78
First Reported 2004
Last Reported 2010
Negated 6
Speculated 5
Reported most in Body
Documents 205
Total Number 262
Disease Relevance 151.23
Pain Relevance 29.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Aqp4) protein complex (Aqp4) transmembrane transport (Aqp4)
cytoplasm (Aqp4)
Anatomy Link Frequency
astrocytes 23
retina 19
brain 17
eyes 15
microglia 8
Aqp4 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
potassium channel 143 100.00 Very High Very High Very High
Inflammation 1420 99.96 Very High Very High Very High
Central nervous system 4607 99.92 Very High Very High Very High
Peripheral nervous system 3 99.92 Very High Very High Very High
Sumatriptan 1 99.90 Very High Very High Very High
Spinal cord 2200 99.80 Very High Very High Very High
Multiple sclerosis 1450 99.80 Very High Very High Very High
imagery 1471 99.76 Very High Very High Very High
Lamotrigine 1 99.56 Very High Very High Very High
unmyelinated 73 99.48 Very High Very High Very High
Disease Link Frequency Relevance Heat
B-cell Lymphoma 22 100.00 Very High Very High Very High
Stroke 177 99.98 Very High Very High Very High
Salivary Gland Disease 146 99.98 Very High Very High Very High
Ocular Hypertension 1729 99.96 Very High Very High Very High
INFLAMMATION 1484 99.96 Very High Very High Very High
Necrosis 176 99.90 Very High Very High Very High
Hydrocephalus 2365 99.84 Very High Very High Very High
Middle Cerebral Artery Infarction 1087 99.82 Very High Very High Very High
Neuromyelitis Optica 16169 99.80 Very High Very High Very High
Multiple Sclerosis 2443 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fluorescence staining for AQP4 and GFAP or lectin revealed that astroglia are the main source of AQP4 expression in the brain, while endothelial cells and microglia are devoid of AQP4 expression (Figure 7 and Figure 8).
Gene_expression (expression) of AQP4 in microglia
1) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.06 Pain Relevance 0
The studies revealed polarised expression of AQP4 under normal physiological conditions.
Gene_expression (expression) of AQP4
2) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.49 Pain Relevance 0
These results support original studies by IHC and high-resolution electron microscopy on cellular domains expressing AQP4 in rat brain under normal conditions [10,14,49].
Gene_expression (expressing) of AQP4 in brain
3) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.57 Pain Relevance 0
IF-stained sections (five from each group) were analysed qualitatively regarding co-localisation of GFAP and AQP4, and AQP4 expression in relation to lectin staining, blinded by one observer (ADS).
Gene_expression (expression) of AQP4
4) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0 Pain Relevance 0.04
Correlation between periventricular AQP4 expression and quantitative MRI
Gene_expression (expression) of AQP4 associated with imagery
5) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.19 Pain Relevance 0.05
We saw no evidence of apical AQP4 expression in ependymal cells at any time point, providing no evidence for the "missing step" in water transport across the ependymal cell membrane.
Gene_expression (expression) of AQP4 in ependymal cell
6) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.37 Pain Relevance 0
By double fluorescence combining AQP4 and lectin staining, we found no evidence of AQP4 expression in microglia.
Gene_expression (expression) of AQP4 in microglia
7) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.13 Pain Relevance 0
This suggests that cerebral AQP4 is neuroprotective and accordingly, the increase in AQP4 expression as presented here might represent a host defense mechanism against kaolin-mediated pathology.
Gene_expression (expression) of AQP4
8) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.06 Pain Relevance 0.06
In both controls and hydrocephalic rats microglia stained by lectin did not express AQP4.
Neg (not) Gene_expression (express) of AQP4 in microglia
9) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.13 Pain Relevance 0.03
Fluorescence staining for AQP4 and GFAP or lectin revealed that astroglia are the main source of AQP4 expression in the brain, while endothelial cells and microglia are devoid of AQP4 expression (Figure 7 and Figure 8).
Gene_expression (expression) of AQP4 in microglia
10) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.05 Pain Relevance 0
AQP4 expression
Gene_expression (expression) of AQP4
11) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.08 Pain Relevance 0
No evidence for neuronal expression of AQP4 currently exists [10,14,51,52].
Gene_expression (expression) of AQP4 in neuronal
12) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.18 Pain Relevance 0
Thus, our data do not suggest changed cell type expression of AQP4 in hydrocephalus, but rather changed level of the constitutive expression.
Gene_expression (expression) of AQP4 associated with hydrocephalus
13) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.62 Pain Relevance 0.18
Linear regression did not propose direct linear correlation of ADC values and AQP4 expression in the periventricular region, in opposition to data presented in one other study [17].
Gene_expression (expression) of AQP4
14) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.93 Pain Relevance 0.29
For tissue analysis antibody-based methods (Western blotting (WB), immunohistochemistry (IHC) and immunofluorescence (IF)) were used to investigate AQP4 expression, cellular localization, and quantification during hydrocephalus.
Spec (investigate) Gene_expression (expression) of AQP4 associated with hydrocephalus
15) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.57 Pain Relevance 0.26
These studies indicate that altered AQP4 expression is rate-limiting for brain water transport and edema implying that altered AQP4 expression maybe functionally significant in cases of disturbed CSF circulation.
Gene_expression (expression) of AQP4 in brain associated with edema
16) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.29 Pain Relevance 0.10
One study [53] arguments for endothelial expression of AQP4 mRNA and protein in preparations of rat cerebral microvessels.
Gene_expression (expression) of AQP4 mRNA
17) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 0.31 Pain Relevance 0.06
These studies indicate that altered AQP4 expression is rate-limiting for brain water transport and edema implying that altered AQP4 expression maybe functionally significant in cases of disturbed CSF circulation.
Gene_expression (expression) of AQP4 in brain associated with edema
18) Confidence 0.78 Published 2010 Journal Cerebrospinal Fluid Res Section Body Doc Link PMC2987763 Disease Relevance 1.04 Pain Relevance 0.10
We retested the compounds with greatest reported potencies, including acetylsulfanilamide, acetazolamide, 6-ethoxy-benzothiazole-2-sulfonamide, topiramate, zonisamide, phenytoin, lamotrigine, and sumatriptan, in AQP4-transfected mammalian cells and primary cultures of brain glial cells, using several sensitive assays of osmotic water permeability.
Gene_expression (transfected) of AQP4 in glial cells associated with sumatriptan and lamotrigine
19) Confidence 0.78 Published 2008 Journal Bioorg. Med. Chem. Section Abstract Doc Link 18572411 Disease Relevance 0.16 Pain Relevance 0.15
AQP4 expression showed a regionalized distribution across the transverse retina in all eyes.
Gene_expression (expression) of AQP4 in eyes
20) Confidence 0.78 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2254964 Disease Relevance 0.29 Pain Relevance 0

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